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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Guided Posters

Male Reproduction and Endocrine Disruptors

ea0049gp143 | Male Reproduction and Endocrine Disruptors | ECE2017

In vitro effects of Bisphenol A on two metabolic receptors signaling: MC4R and FFAR1

Munier Mathilde , Louvigne Mathilde , Rudelle Helene , Gourdin Louis , Briet Claire , Henrion Daniel , Chabbert Marie , Coutant Regis , Rodien Patrice

Metabolic diseases (type 2 diabetes (T2D) and obesity) prevalence is increasing in the world. This is partly related to a change in lifestyle with an increase of caloric intake and a decrease of physical activity. Environmental causes are also involved among them exposure to bisphenol A (BPA). The mode of action of the latter is unknown. Beyond a suggesting effect relayed by nuclear receptors, we propose that BPA can act by modulating the functionality of G protein-coupled rec...

ea0049gp144 | Male Reproduction and Endocrine Disruptors | ECE2017

Altered protein expression of cell cycle- and EMT-associated genes by bisphenol compounds in MCF-7 CV human breast cancer cells via estrogen receptor dependent pathway

Ayala-Cuellar Ana Patricia , Hwang Kyung-A , Choi Kyung-Chul

Bisphenol-A (BPA) has been considered as an endocrine disrupting chemical (EDC) because it can exert estrogenic properties. For bisphenol-S (BPS) and bisphenol-F (BPF) that are BPA analogs and substitutes, their risk to estrogen-dependent cancer has been reported rarely compared with the numerous cases of BPA. In this study, we examined whether BPA, BPS, and BPF can lead to the proliferation, migration, and epithelial mesenchymal transition (EMT) of MCF-7 clonal variant (MCF-7...

ea0049gp145 | Male Reproduction and Endocrine Disruptors | ECE2017

Reproductive toxicity of low dose nonylphenol in mice: a two-generation study

Lee Sung-Ho , Kim Yong Bin , Kim Hee Su

Nonylphenol (NP), a member of alkylphenol family, has been widely used in both industry and household. NP is classified as an endocrine-disrupting chemical and is known to act as an agonist of the GPER (GPR30). The aim of this study was to address the two-generational effects of para-nonylphenol (NP) on the body weights, reproductive organ weights and histopathologies of ICR mice. We also test the potential reproductive toxicity of octylglucuronide (OG), a substitute candidate...

ea0049gp146 | Male Reproduction and Endocrine Disruptors | ECE2017

Psychological rather than organic and/or relational components are involved in sexual dysfunction in Young/Middle aged human immunodeficiency virus (HIV)-Infected Men

Decaroli Maria Chiara , De Vincentis Sara , Diazzi Chiara , Zona Stefano , Guaraldi Giovanni , Santi Daniele , Rochira Vincenzo

Background: HIV-infection is associated to an increased prevalence of erectile dysfunction (ED). In HIV-infected men ED seems to be less related to serum Testosterone (T), depending from other factors.Aim: To investigate the role of different components (organic, relational, psychological) of erectile function by using validate questionnaires in HIV-infected men with normal serum T.Methodology: Prospective, cross-sectional, observa...

ea0049gp147 | Male Reproduction and Endocrine Disruptors | ECE2017

Effects of physical exercise or metformin on testosterone deficiency and erectile dysfunction associated to metabolic syndrome

Vignozzi Linda , Filippi Sandra , Comeglio Paolo , Cellai Ilaria , Corcetto Francesca , Corno Chiara , Maggi Mario

Metabolic Syndrome (MetS) is a cluster of clinical conditions, associated to an increased cardiovascular and metabolic risk, to hypogonadism and erectile dysfunction (ED). Lifestyle modification (including physical exercise, PhyEx) and metformin (MET) are well-known treatments for the condition. We established an animal model of MetS that recapitulates the human phenotype, including andrologic derangements.The aim of this study was to investigate in expe...

ea0049gp148 | Male Reproduction and Endocrine Disruptors | ECE2017

Impacts of a single ablative dose of radio iodine therapy for differentiated thyroid carcinoma on testicular function: results from the SAPIRA study

Bourcigaux Nathalie , Rubino Carole , Berthaut Isabelle , Donadille Bruno , Toubert Marie Elisabeth , Leenhardt Laurence , Corone Catherine , Petrot-Keller Isabelle , Brailly-Tabard Sylvie , Beaufaron Julie , Simon Tabassome , Siffroi Jean-Pierre , De Vathaire Florent , Sclumberger Martin , Bouchard Philippe , Christin-Maitre Sophie

Background: Radioactive iodine therapy (RAI) is a classical therapeutic approach in patients with differentiated thyroid carcinoma (DCT). Few data are currently available on RAI¬ís potential impacts on testicular function.Design: A longitudinal prospective multi-center study (PHRC N°P040419) included male patients before a single radioiodine dose of 3.7 GBq of I 131 (V0), at 3 months (V3) and 13 months (V13) post treatment.<p clas...

ea0049gp149 | Male Reproduction and Endocrine Disruptors | ECE2017

Presentation, clinical features and long-term follow-up of Leydig cell tumours of the testis: 77 cases from a single center experience

Isidori Andrea M. , Giannetta Vincenzo , Gianfrilli Daniele , Lauretta Rosa , Tarsitano Maria Grazia , Fattorini Giorgio , Pofi Riccardo , Pozza Carlotta , Lenzi Andrea

Introduction: With the improved imaging techniques, Leydig cell tumours (LCTs) are frequently found, accounting up to 22% of testicular tumours. The natural history of LCTs is relatively unknown, because of the small size and heterogeneity of available studies. Since LCTs are often removed, long-term follow-up is missing. The aim of this study was to report the experience with a large cohort of prospectively collected LCTs.Materials and methods: Patients...

ea0049gp150 | Male Reproduction and Endocrine Disruptors | ECE2017

Semen quality in patients with adult-onset hypogonadotropic hypogonadism

Andreassen Mikkel , Juul Anders , Feldt-Rasmussen Ulla , Jorgensen Niels

Introduction: Gonadotropins from the pituitary gland are essential for testosterone production and spermatogenesis. However, little is known about semen quality in patients with adult onset gonadotropin insufficiency.Aim: To investigate semen quality in men with adult onset hypogonadotropic hypogonadism requiring testosterone replacement therapy.Patients and method: A single center study comprising all hypogonadal men with pituitar...