Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Guided Posters

Neuroendocrinology & Growth Hormones

ea0049gp151 | Neuroendocrinology & Growth Hormones | ECE2017

Growth hormone-releasing hormone (GHRH) antagonists, MIA-602 and MIA-690, inhibit survival and proliferation of human pleural mesothelioma cells

Villanova Tania , Gesmundo Iacopo , Taliano Marina , Ghigo Ezio , Schally Andrew V , Granata Riccarda

Human malignant pleural mesothelioma (MPM) is a rare but aggressive neoplasm, arising from pleural mesothelial cells, generally due to asbestos exposure. Different growth factors are involved in the pathogenesis of MPM and in resistance to therapy; moreover, chemotherapy with cisplatin and antifolates, like pemetrexed (PEM), is the first-line treatment for inoperable MPM. Growth hormone-releasing hormone (GHRH), apart from stimulating GH secretion in the pituitary, exerts many...

ea0049gp152 | Neuroendocrinology & Growth Hormones | ECE2017

Somapacitan expected to provide IGF-I levels suitable for once-weekly dosing in children

Juul Rasmus , Rasmussen Michael , Agerso Henrik , Overgaard Rune

Somapacitan is a long-acting growth hormone (GH) intended for once-weekly subcutaneous administration. As for GH, the mechanism of action of somapacitan is either directly or indirectly via insulin-like growth factor I (IGF-I). A PK/PD model of somapacitan was developed from the pharmacokinetics (PK) and IGF-I levels from three phase 1 trials data: a single dose/multiple dose trial (0.02–0.24 mg/kg per week) in healthy adults, a multiple dose trial in adults with growth h...

ea0049gp153 | Neuroendocrinology & Growth Hormones | ECE2017

Evaluating CHARGE syndrome in CHD7-positive CHH patients: clinical implications

Xu Cheng , Cassatella Daniele , Sloot Almer van der , Hauschild Michael , Quinton Richard , De Geyter Christian , Fluck Christa , Feller Katrin , Bartholdi Deborah , Nemeth Attila , Halperin Irene , Djurdjevic Sandra Pekic , Papadakis Georgios , Dwyer Andrew , Marino Laura , Pignatelli Duarte , Huang Carol , Niederlander Nicolas , Acierno James , Pitteloud Nelly

Context: Congenital hypogonadotropic hypogonadism (CHH) and CHARGE syndrome are clinically and genetically overlapping syndromes, with mutations in the CHD7 gene presenting in both disorders. However systematic evaluation of CHARGE features in CHD7-positive CHH patients is seldom performed.Objective: This study aims to systematically evaluate CHARGE features in CHD7-positive patients and explore the phenotype-genotype correlation.<p...

ea0049gp154 | Neuroendocrinology &amp; Growth Hormones | ECE2017

The effect of chronic hypothalamic-pituitary-adrenal axis activation on hypothalamic glucagon-like peptide-1 action in an animal model of depression and in vitro studies

Detka Jan , Kurek Anna , Kucharczyk Mateusz , Slusarczyk Joanna , Glombik Katarzyna , Lason Wladyslaw , Budziszewska Boguslawa

Hypersensitivity of hypothalamic–pituitary–adrenal (HPA) axis is considered to be an important factor in the pathogenesis of depression. Interestingly, glucagon-like peptide-1 (GLP-1) – an incretin hormone involved in the maintenance of glucose homeostasis in the periphery is known to activate HPA axis. The aim of the present study was to investigate whether prenatal stress (an animal model of depression) may influence levels of GLP-1 and GLP-1 receptor (GLP-1R)...

ea0049gp155 | Neuroendocrinology &amp; Growth Hormones | ECE2017

A novel purified polyclonal antibody towards T-Pit is a reliable marker of corticotroph cell differentiation

Sjostedt Evelina , Bollerslev Jens , Ponten Fredrik , Casar-Borota Olivera

Classification of pituitary neuroendocrine tumours (NETs) or pituitary adenomas is based on the expression of the anterior lobe pituitary hormones (FSH, LH, GH, Prolactin, TSH, ACTH and alpha-subunit of the glycoprotein hormones). Assessment of the transcription factors SF-1, Pit-1 and T-Pit has been a complement to the classification. Tumours negative for both pituitary hormones and transcription factors have been designated as null-cell adenomas. However, lack of sensitive a...

ea0049gp156 | Neuroendocrinology &amp; Growth Hormones | ECE2017

Liraglutide treatment prevented the increased expression of proinflammatory cytokines in the hippocampus of male pups in a perinatal stress model of food restriction

Diz-Chaves Yolanda , Toba Laura , Fandino Juan , Gonzalez-Matias Lucas , Garcia-Segura Luis Miguel , Mallo Federico

Adverse events during gestation in rodents, results in an enhancement of immune function, including elevated levels of inflammatory cytokines in the brain. Liraglutide is a GLP-1 receptor agonists known to exert neuroprotective effects in brain. The aim of this study was to elucidate if liraglutide given to food restricted (FR) pregnant rats may prevent the deleterious effects of FR in the hippocampal inflammatory status of male and female pups at 21 days of age (D21). 20 Spra...

ea0049gp157 | Neuroendocrinology &amp; Growth Hormones | ECE2017

Predictors of permanent, transient and three-phase postoperative diabetes insipidus

Mikhaylova Daria , Dzeranova Larisa , Pigarova Ekaterina , Rozhinskaya Ludmila , Grigoriev Andrey , Azizyan Vilen , Ivashenko Oksana

Objectives: To evaluate predictors of permanent, transient and three-phase diabetes insipidus (DI) in patients undergoing endoscopic endonasal transsphenoidal surgery.Patients and methods: The study included 154 patients undergoing endoscopic endonasal transsphenoidal surgery (122 women and 32 men) age from 18 to 65 years (median 40 (31;52)). 73 patients with Cushing disease, 66 patients with acromegaly, four patients with prolactinomas, nine patients wi...

ea0049gp158 | Neuroendocrinology &amp; Growth Hormones | ECE2017

The effect of chronic tianeptine administration on NLRP3 inflammasome pathway – study in an animal model of depression

Trojan Ewa , Kurek Anna , Chamera Katarzyna , Slusarczyk Joanna , Glombik Katarzyna , Basta-Kaim Agnieszka

Introduction: Recently, the immune hypothesis of depression has gained a new dimension because of inflammasomes. NLRP3 inflammasome is a protein complex and its activation leads to stimulation of the enzyme caspase 1 responsible for generation of active form of pro-inflammatory cytokines: IL-1 β and IL-18. Recently postulated ‘inflammasome theory of depression’ assumes that depression is based on a disturbance of the mechanisms regulating NLRP3 complexes and unc...

ea0049gp159 | Neuroendocrinology &amp; Growth Hormones | ECE2017

Pituitary androgen receptor signalling is a novel negative regulator of prolactin production

O'Hara Laura , Tissier Paul Le , Smith Lee

The classical paradigm of lactotroph prolactin production and release is based around tonic inhibition by hypothalamic dopamine and stimulation by factors such as estrogen. We have recently shown that conditional ablation of pituitary androgen receptor (Foxg1-Cre ARKO) surprisingly does not change the concentration of circulating gonadotrophins but increases circulating prolactin in male mice; highlighting androgen signalling as a novel negative regulator of prolactin producti...

ea0049gp160 | Neuroendocrinology &amp; Growth Hormones | ECE2017

Somatic mutations in USP8 are frequent events in pituitary tumors causing Nelson’s syndrome

Perez-Rivas Luis G , Theodoropoulou Marily , Puar Troy H , Fazel Julia , Stieg Mareike R , Ferrau Francesco , Assie Guillaume , Gadelha Monica R , Deutschbein Timo , Fragoso Maria C , Kusters Benno , Korbonits Marta , Bertherat Jerome , Stalla Gunter K , Hermus Ad R , Beuschlein Felix , Reincke Martin

Recent studies have reported a high prevalence of USP8 mutations in corticotroph adenomas causing Cushing’s disease. Nelson’s syndrome is a potentially life-threatening complication of bilateral adrenalectomy in patients with refractory Cushing’s disease that is caused by the development of an ACTH-secreting tumor in the pituitary gland. Whether USP8 alterations are also present in Nelson’s tumors has not been studied in detail so far....