Introduction: The prevalence of cardiometabolic disorders such as type 2 diabetes mellitus, dysipidemia and metabolic syndrome is increased in patients with Klinefelter syndrome (KS). The mechanism by which cardiometabolic risk increases in patients with KS remains to be completely elucidated. We investigated the presence of inflammation, insulin resistance and endothelial dysfunction in an unconfounded population of KS.
Methods: A total of 31 patients with KS (mean age 21.59±1.66 years) and 33 healthy control subjects (mean age: 22.15±1.03 years) were enrolled. The demographic parameters, Asymmetric dimethylarginine (ADMA), high sensitive C reactive protein (hs-CRP) and homeostatic model assessment of insulin resistance (HOMA-IR) levels were measured in patients and controls.
Results: The patients had higher insulin, HOMA-IR and ADMA levels (P< 0.001 for all) and lower HDL-C (P=0.002) and total testosterone (P< 0.001) levels, compared to the healthy controls. There were significant negative correlations between the total testosterone levels and ADMA (r=−0.479, P< 0,001), hsCRP (r=−0.291, P=0.034), and significant positive correlation with HDL-C (r=0.429, P=0.001) levels. The multivariate analysis has shown that total testosterone (β=−0.412, P=0.001) and TG (β=0.332, P=0.009) levels were the significant independent determinants of the plasma ADMA levels.
Conclusion: The results of the present study show that endothelial dysfunction and insulin resistance are prevalent even in the very young subjects with KS, who have no metabolic or cardiac problems at present.
20 May 2017 - 23 May 2017