ECE2017 Eposter Presentations: Thyroid Thyroid (non-cancer) (260 abstracts)
Evaluation of interrelationships between thyroid function, autoimmunity, insulin resistance and lipid profile in Graves’ disease
António Carujo 1 , Celestino Neves 2 , João Sérgio Neves 2 , Sofia Castro Oliveira 2 , Oksana Sokhatska 3 , César Esteves 2 , Miguel Pereira 2 , José Luís Medina 1 , Luís Delgado 3 & Davide Carvalho 1,
1Faculty of Medicine, University of Porto, Porto, Portugal; 2Endocrinology Service, São João Hospital, Faculty of Medicine, University of Porto, Porto, Portugal; 3Immunology Department, São João Hospital, Faculty of Medicine, University of Porto, Porto, Portugal; 4Instituto de Investigação e Inovação em Saúde, Faculty of Medicine, University of Porto, Porto, Portugal.
Background: Thyroid hormones modulate the lipoprotein and glucose metabolisms. In hyperthyroidism, insulin resistance is a frequent finding.
Aim: To assess interrelationships between thyroid function, autoimmunity, lipid profile, glucose metabolism and other cardiovascular risk factors in patients with Graves’ disease.
Methods: We recorded free T3 (FT3), free T4 (FT4), TSH, TSH receptor antibodies (TRAB), parameters of the lipid profile, glucose metabolism [including insulin resistance marker Homeostasis Model Assessment for Insulin Resistance (HOMA-IR)], C reactive protein (CRP) and homocysteine in 126 patients with Graves’ disease in the first cycle of treatment with methimazole (93% females, mean age 44.8±15.2 years). Patients were divided in subgroups according to: TRAB (positive (n=57) or negative (n=69)) and thyroid function (normal (n=74), subclinical (n=29) or clinical hyperthyroidism (n=22)). Spearman correlations, T-tests and Mann–Whitney tests were performed for statistical analysis.
Results: Comparing TRAB- and TRAB+ groups, significantly lower apolipoprotein B (80.3(73.2–87.4) vs 89.7(83.5–95.8)mg/dl, P=0.047) and TSH (0.180(0.002–1.080) vs 1.020(0.235–2.055]μUI/ml, P<0.001) were found in the TRAB+ group. Comparing with the normal thyroid function group, patients in the clinical hyperthyroid group presented significantly lower apolipoprotein B (70.9(57.2–84.6) vs 89.7(83.7–95.8)mg/dl, P=0.007) and higher fasting glucose (96.0(83.0–109.0) vs 86.4(83.8–89.0)mg/dl, P=0.019), insulin (10.4(6.2–15.8) vs 7.5(4.8–9.7)μUI/ml, P=0.021), HOMA-IR (2.09(1.29–4.53) vs 1.55(0.95–2.13), P=0.023) and CRP (0.57(0.20–0.93) vs 0.20(0.07–0.38)mg/l, P=0.005). No significant differences were found between the subclinical hyperthyroid group and the remaining groups. There was a negative correlation between TSH and TRAB (r=−0.386, P<0.001). Apolipoprotein B was positively correlated with TSH (r=0.236, P=0.016), and negatively with TRAB (r=−0.211, P=0.030). Both FT3 and FT4 were positively correlated with fasting insulin (r=0.268, P=0.008 and r=0.226, P=0.025, respectively) and HOMA-IR (r=0.258, P=0.010 and r=0.259, P=0.010, respectively). FT4 was also positively correlated with fasting glucose (r=0.269, P=0.008).
Conclusion: In patients with Graves’ disease, the interrelationships between thyroid function, autoimmunity, insulin resistance and lipid profile may contribute to the increased cardiovascular risk.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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