ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Diabetes therapy (52 abstracts)
Intralesional epidermal growth factor treatment on diabetic foot ulcers
Aydin Cifci 1 , Birhan Oktas 2 , Senay Arikan Durmaz 3 , Askin Gungunes 3 , Irfan Karahan 4 & Taner Sarak 5
1Department of Internal Medicine, School of Medicine, Kirikkale University, Kirikkale, Turkey; 2Department of Orthopedics and Traumatology, School of Medicine, Kirikkale University, Kirikkale, Turkey; 3Department of Endocrinology and Metabolism, School of Medicine, Kirikkale University, Kirikkale, Turkey; 4Department of Internal Medicine, Yenimahalle Traning and Research Hospital, Ankara, Turkey; 5Department of Cardiology, School of Medicine, Kirikkale University, Kirikkale, Turkey.
Objective: Treatment of diabetic foot ulcer is complex and difficult. Blood glucose regulation, debridment and surgical revascularization are used in management of diabetic foot ulcer. Intralesional Epidermal Growth Factor (EGF) is a new treatment approach for diabetic foot ulcer. We report our experience with eight patients with diabetic foot ulcer who were treated by intralesional EGF.
Patients and methods: A total of eight patients whose diabetic foot ulcers did not fully recover with other treatments were included our study (Table 1).
Results: Complete healing was observed all diabetic foot ulcers after the intralesional EGF treatment.
| No. | Age year | Sex | Duration of dm | Lesion place | Wagner Grade | Prior treatment | Numbers of EGF doses |
| 1 | 74 | Male | 20 | Right 5. Phalanx | 4 | Amputation from left 4.metatars level | 12 |
| 2 | 65 | Male | 15 | Left foot 5th Metatars | 3 | Debridment+ Negative-pressure wound therapy | 9 |
| 3 | 60 | Male | 22 | Right foot First Phalanx | 4 | Amputation+debridment | 5 |
| 4 | 66 | Male | 16 | Left foot First Phalanx | 3 | Amputation+debridment | 12 |
| 5 | 56 | Male | 33 | Left heel, 2th and 3th Phalanx | 3 | Amputation+debridment | 12 |
| 6 | 57 | Female | 35 | Left First Phalanx and heel | 3 | Debridment | 9 |
| 7 | 40 | Female | 25 | Right 3th and 4th Metatars | 3 | Debridment | 9 |
| 8 | 64 | Male | 20 | Left- Foot sole | 3 | Debridment | 5 |
Conclusion: Our diabetic foot ulcers improved with intralesional EGF. Although our results are quite impressive, this treatment is very expensive and caused of some allergic reactions. Relation with malignancies is not known for long-term. In our opinion, intralesional EGF treatment should be used on wounds that did not heal with the other treatments.
Article tools
My recent searches
My recently viewed abstracts
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more