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Endocrine Abstracts (2017) 49 EP604 | DOI: 10.1530/endoabs.49.EP604

1Department of Internal Medicine, School of Medicine, Kirikkale University, Kirikkale, Turkey; 2Department of Orthopedics and Traumatology, School of Medicine, Kirikkale University, Kirikkale, Turkey; 3Department of Endocrinology and Metabolism, School of Medicine, Kirikkale University, Kirikkale, Turkey; 4Department of Internal Medicine, Yenimahalle Traning and Research Hospital, Ankara, Turkey; 5Department of Cardiology, School of Medicine, Kirikkale University, Kirikkale, Turkey.

Objective: Treatment of diabetic foot ulcer is complex and difficult. Blood glucose regulation, debridment and surgical revascularization are used in management of diabetic foot ulcer. Intralesional Epidermal Growth Factor (EGF) is a new treatment approach for diabetic foot ulcer. We report our experience with eight patients with diabetic foot ulcer who were treated by intralesional EGF.

Patients and methods: A total of eight patients whose diabetic foot ulcers did not fully recover with other treatments were included our study (Table 1).

Results: Complete healing was observed all diabetic foot ulcers after the intralesional EGF treatment.

Table 1
No.Age yearSexDuration of dmLesion placeWagner GradePrior treatmentNumbers of EGF doses
174Male20Right 5. Phalanx4Amputation from left 4.metatars level12
265Male15Left foot 5th Metatars3Debridment+ Negative-pressure wound therapy 9
360Male22Right foot First Phalanx4Amputation+debridment5
466Male16Left foot First Phalanx3Amputation+debridment12
556Male33Left heel, 2th and 3th Phalanx3Amputation+debridment12
657Female35Left First Phalanx and heel3Debridment9
740Female25Right 3th and 4th Metatars3Debridment9
864Male20Left- Foot sole3Debridment5

Conclusion: Our diabetic foot ulcers improved with intralesional EGF. Although our results are quite impressive, this treatment is very expensive and caused of some allergic reactions. Relation with malignancies is not known for long-term. In our opinion, intralesional EGF treatment should be used on wounds that did not heal with the other treatments.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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