ECE2017 Eposter Presentations: Reproductive Endocrinology Female Reproduction (62 abstracts)
Omentin-1, a potential link between chronic low grade inflammation, metabolic and reproductive features of polycystic ovary syndrome
Soulmaz Shorakae 1, , Sally Abell 1, , Barbora de Courten 1, , Gavin Lambert 3, , Danielle Hiam 5 , Nigel Stepto 1, , Eveline Jona 1 , Lisa Moran 1 & Helena Teede 1,
1Monash Centre for Health Research and Implementation, Monash University, Melbourne, Australia; 2Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Australia; 3Human Neurotransmitters Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, Australia; 4Department of Physiology, Monash University, Melbourne, Australia; 5Institute of Sport Exercise and Active Living (ISEAL), Victoria University, Melbourne, Australia.
Background: Polycystic ovary syndrome (PCOS) is associated with features linked to metabolic syndrome including visceral adiposity, dyslipidemia and impaired glucose homeostasis. Adipose tissue produces adipocytokines which contribute to regulation of insulin sensitivity and reproduction. Omentin-1 is an adipokine with anti-inflammatory and insulin sensitizing roles produced by adipocytes. The exact role of mentin-1 in PCOS remains unclear as studies have reported reduced or unchanged levels in PCOS.
Methods: To determine the relationships between PCOS status, adipocytokines including omentin-1 and etiological features of PCOS we measured serum omentin-1, interleukin-6 (IL-6), high sensitivity CRP (hs-CRP), androgens, SHBG, fasting glucose and insulin levels in an observational study of community recruited PCOS and controls.
Results: 49 women with PCOS (age 29.8±5.9 years, BMI: 29.0±5.4 kg/m2) and 25 healthy controls (age 37.6±7.8 years, BMI: 28.9±4.0 kg/m2) were recruited. Homeostatic model assessment for insulin resistance (HOMA-IR) (P=0.006), free androgen index (FAI) (P=0.01) and Ferriman-Galway score (P<0.001) were higher in PCOS. Women with PCOS had lower omentin-1 (median (IQR): 68.76(67.17) vs 112.45(67.42)) (P=0.005) independent of obesity. Omentin-1 correlated significantly with hs-CRP, IL-6, HMW-adiponectin, BMI, percentage of body fat, insulin, low density lipoprotein (LDL), triglycerides and total ovarian volume in women with PCOS. Multiple regression analyses revealed omentin-1 was explained by triglycerides (Beta: −0.177, P=0.03) and total ovarian volume (Beta: −0.009, P=0.025).
Conclusion: Omentin-1 is significantly lower in women with PCOS and correlates significantly with other inflammatory markers, metabolic parameters and total ovarian volume. This finding suggests omentin-1 as a potential link between metabolic and reproductive features of PCOS and chronic low grade inflammation.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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