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Endocrine Abstracts (2017) 49 EP1232 | DOI: 10.1530/endoabs.49.EP1232


Department of Endocrinology, Charles Nicolle Hospital, Tunis, Tunisia.

Introduction: Cardiothyreosis (CT) is the most frequent and dangerous complication of hyperthyroidism (HT). It is defined as an association of HT with severe heart abnormalities such as: rhythmic troubles, heart and/or coronary insufficiency. The aim of our study was to describe the frequency and the clinical characteristics of CT in Graves’ disease (GD).

Methods: Patients with GD were enrolled into a retrospective study. The prevalence and the clinical characteristics of CT were described.

Results: Out of 90 participants with GD, 12.2% patients presented with cardiothyreosis. Their sex ratio (M/F) was 9/2 and their mean age was 46.72±15.11 years. CT was the circumstance of discovery of GD in 2.2% of cases. Its clinical manifestations were palpitation in 75.5%; dyspnea in 24.4% and anginal pain in 5.6%. Different modes of presentation of CT were found: ten cases of atrial fibrillation (ACFA) (90.9%); five cases of Heart failure (45.45%) and three cases of coronary insufficiency (27.27%). Systolic blood pressure was on average 128±11.6 mmHg and mean diastolic blood pressure was 76±19 mmHg. Mean heart frequency was measured at 106±20 beats/min. Underlying mitral valvulopathy was found in two cases. Six out of 11 patients presented anemia (54.5%) and 90.9% had severe hyperthyroidism. Arrhythmia was reduced in 72.7% of the cases, after treating with betablocker.

Conclusion: CT, although rare, remains a serious life-threatening complication of GD. The ACFA is its most common clinical form and underlying cardiac disease is often present.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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