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Endocrine Abstracts (2017) 49 EP1269 | DOI: 10.1530/endoabs.49.EP1269

1Serviço de Endocrinologia, Diabetes e Metabolismo, Hospital de Santa Maria, Centro Hospitalar de Lisboa Norte, Lisboa, Portugal; 2Instituto de Medicina Nuclear da Faculdade de Medicina de Lisboa, Lisboa, Portugal; 3Statistical Independent, Lisboa, Portugal.

Objective: The aim of this study was to evaluate the treatment outcomes in patients with autonomous toxic nodule (ATN) that received a radioiodine treatment (RAIT) and to determine the influence of age, gender, nodule size and iodine activity.

Methods: We performed a retrospective study of all RAIT done for hyperthyroidism (n=149) in our hospital during 2014 and 2015. Patients with ATN submitted to RAIT were selected to analysis. We studied 58 patients (mean age 59.6±13.98 years), a total of 59 treatments, corresponding to 39.6% of all RAIT. Treatment success was analysed according to demographic (age and gender) and clinical data (thyroid function tests 1 year after RAIT, iodine activity administered and nodule size). Activities of 5 or 10 mCi were the most used. Treatment success was defined as achieving euthyroidism or hypothyroidism 1 year after the last RAIT. For statistical data analyses was used a 95% confidence interval (sig<0.05).

Results: The cure rate was 84.6%. Hypothyroidism was observed in 25.6% (10 patients). Only 6 patients remained in hyperthyroidism. Age and nodule size did not influence the outcome. Additionally, no correlation was found between gender and iodine activity in therapeutic effectiveness. Although not statistically significant, the cure rate was higher with 10 mCi (92.6%) comparing with 5 mCi (72.7%).

Conclusion: There is a trend for a higher effectiveness with 10 mCi than with 5 mCi. The cure rate with 10 mCi is similar to those described in the literature for 15 and 20 mCi, with a lower rate of hypothyroidism.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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