Endocrine Abstracts (2017) 49 EP1273 | DOI: 10.1530/endoabs.49.EP1273

Evaluation of circulating irisin levels in patients with never treated overt hyperthyrodisim

Asena Gokcay Canpolat, Mustafa Sahin, Demet Corapcioglu, Rıfat Emral & Ali Rıza Uysal


Ankara University Faculty of Medicine, Ankara, Turkey.


Aims: Because of an increased metabolic activity and thermogenesis in hyperthyroidism, we aimed to evaluate the association of serum irisin with thyroid hormones.

Methods: A total of 25 hyperthyroid patients and 24 age- and gender-matched healthy controls were enrolled. Serum irisin levels, thyroid hormones and body compositions were analyzed.

Results: Serum irisin levels were significantly higher in hyperthyroid group (P<0.001). Distribution of fat free mass and muscle mass was similar between study groups. Serum irisin level has a negative correlation with TSH level (P<0.001), %fat mass (P=0.021) and positive correlation with TSH receptor antibody (TRAB) level (P=0.002).

Conclusion: Our results showed that increased serum irisin levels in hyperthyroid patients might be associated with the effects of TSH.

Keywords: Hypertyroidism; irisin; TSH receptor antibody

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