ECE2017 Eposter Presentations: Thyroid Thyroid (non-cancer) (260 abstracts)
Nicotinamide phosphoribosyltransferase expression in thyroid glands of patients with Graves’ disease
Nadia Sawicka-Gutaj 1 , Miroslaw Andrusiewicz 2 , Agata Czarnywojtek 1, , Joanna Waligorska-Stachura 1 , Maciej Biczysko 4 , Jerzy Skrobisz 4 , Jerzy Sowinski 1 & Marek Ruchala 1
1Poznan University of Medical Sciences, Department of Endocrinology, Metabolism and Internal Medicine, Poznan, Poland; 2Poznan University of Medical Sciences, Department of Cell Biology, Poznan, Poland; 3Poznan University of Medical Sciences, Department of Pharmacology, Poznan, Poland; 4Department of General Surgery and Multiple Trauma, with Division of Gastroenterological and Endocrine Surgery, Provincial Hospital, Poznan, Poland.
Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) overexpression was reported in many autoimmune diseases. We have also found NAMPT overexpression in leukocytes of patients with Graves’ orbitopathy. Therefore, we aimed to analyze NAMPT expression level in thyroid gland of patients with Graves’ disease with orbitopathy and without orbitopathy, and in healthy thyroid gland. We have analyzed 80 thyroid tissue samples of patients who underwent thyroidectomy. Among these, there were 41 patients with Graves’ disease (20 patients with orbitopathy and 21 patients without orbitopathy), and 39 samples of healthy thyroid tissue. NAMPT overexpression was found in thyroid glands of patients with Graves’ orbitopathy (P<0.000001). NAMPT expression in patients with Graves’ disease without orbitopathy was similar to healthy controls. Our results suggested that NAMPT might be involved in the inflammatory cascade in Graves’ orbitopathy.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more