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Endocrine Abstracts (2017) 49 EP1299 | DOI: 10.1530/endoabs.49.EP1299

Ain Shams University, Cairo, Egypt.


Multiple factors contribute to the etiology of Graves disease(GD), including genetic and environmental factors.vitamin D is well known in calcium metabolism and has also been shown to be a modulator in innate and adaptive immunity. There is a well-established link between vitamin D deficiency and various autoimmune diseases. The prevalence of vitamin D deficiency was reported to be common in patients with GD. Whether vitamin D deficiency has a causal relationship with GD remains controversial.Aim:to evaluate the effect of vitamin D supplementation in patients with GD with and without opthalmopathy methods: A randomized prospective study was conducted on 60 adult patients with GD.

Group 1: 20 patients with GD receiving 30 mg of methimazole daily.

Group 2: 40 patients with GD receiving same dose of methimazole and vit. D3 200 000 IU/month. Patients were followed up for 3 months.

Results: 40% of patients in group 1 and 72.5% in Group 2 were vit. D deficient,Vit. D was significantly correlated with thyroid volume and degree of exophthalmos. Gp 2 had significant lower thyroid volume and better effect on degree of exopthalomos.

Conclusion: Vit. D suuplementation for GD has a favourable effect on thyroid volume and degree of exophthalmos.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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