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Endocrine Abstracts (2017) 49 EP1329 | DOI: 10.1530/endoabs.49.EP1329

1Ankara Numune Education and Research Hospital, Ankara, Turkey; 2Hitit University Hospital, Corum, Turkey.

Introduction: Hyperthyroidism is the condition that occurs due to excessive release of thyroid hormone by the thyroid gland. Anti-thyroid drugs are usually the first choice of the treatment but surgery and radioactive iodine can also be used in treatment of hyperthyroidism. Plasmapheresis is a rapid and effective treatment option in cases where immediate euthyroidism is needed to be obtained due to complications of thyrotoxicosis and major side effects of antithyroid drugs.

Material and method: Between January 2012 and December 2016, we evaluated patients who received plasmapheresis to provide immediate euthyroidism due to severe hyperthyroidism or side effects of anti-thyroid drugs or urgent non-thyroid surgery were included to the study.

Results: Eighteen patients were included the study, of whom 11 were female and seven were male. The mean age was 52.44 years. Seven patients had TDG (%38.9), two patients had TDMNG (%11.1), two patients had TA (%11.1), four patients had TMNG (%22.2) and one patient had amiodarona induced thyrotoxikosis (%5.6). Additionally, plasmapheresis was performed to achieve euthyrodism before non-thyroid surgery in two patients (11.1%). The mean plasmapheresis sessions was 5.22. The mean sessions was 3.62 for patients with TDG and TDMNG, whereas it was 6.43 for patients with TA and TMNG (P:0.029). The decrease of mean fT4 and fT3 were 48% and 65%, respectively (P<0.0001). Anaphylaxis was seen only in one patient due to fresh frozen plasma. So treatment was changed to albumin.

Conclusions: Although plasmapheresis is not commonly used for the treatment of the hypertyroidism, it is a reliable and effective treatment option for patients who can not use antithyroid drugs or hyperthyroidism can not resolve with these drugs before total thyroidectomy, RAI or non thyroid emergency surgery.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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