Introduction: Neutrophil/lymphocyte (N/L) ratio is considered as a sign of systemic inflammation in recent years. In our study, we aimed to investigate N/L ratio in hyperthyroid patients and healthy control group.
Material & methods: A total of 121 hyperthyroid patients (71 patients with Graves disease and 50 patients with other causes of hyperthyroidism) and 40 healthy volunteers were enrolled. Complete blood count was obtained from both group and thyroid function tests were obtained from hyperthyroid patients.
Results: There was no significant difference between hyperthyroid patients and control group in terms of gender, leukocyte and lymphocyte count. There was a statistically significant difference between groups in terms of neutrophil count and N/L ratio (P=0.003 and P<0.001). Surprisingly, neutrophil count and N/L ratio were significantly lower in Graves patients. We also find a significant negative correlation between serum free T3 levels and neutrophil count (r=−0.28, P=0.01).
Conclusion: N/L ratio was lower in Graves patients than in the control group. Slowing of granulopoiesis, shortening of the life span of circulating neutrophils, and the development of anti-neutrophilic antibodies in autoimmune thyroid diseases may be responsible for this condition. N/L ratio should not be used as an indicator of inflammation in hyperthyroid patients.
20 - 23 May 2017
European Society of Endocrinology