ECE2017 Eposter Presentations: Thyroid Thyroid (non-cancer) (260 abstracts)
The impact of levothyroxine sodium treatment on dynamic thiol/disulphide homeostasis in overt hypothyroidism
Cemile Bicer 1 , Ihsan Ates 2 , Murat Aydin 3 , Mustafa Altay 2 , Canan Topcuoglu 4 , Salim Neselioglu 1 , Özcan Erel 1 & Fatma Meric Yilmaz 1
1Yildirim Beyazit University Medical Faculty, Ankara, Turkey; 2Ankara Numune Training and Research Hospital, Department of Internal Medicine, Ankara, Turkey; 3Namik Kemal University Medical Faculty, Department of Biochemistry, Ankara, Turkey; 4Ankara Numune Training and Resaerch Hospital, Department of Biochemistry, Ankara, Turkey.
Objective: Thiols are organic compounds that contain sulphydryl group (-SH) and have important role in preventing oxidative stress especially in cells. The aim of our study is to investigate the relationship between hypothyroidism due to HT and the thiol disulfide homeostasis, the effect of treatment on this homeostasis and to demonstrate the utility of thiol/disulphide homestasis as a marker for assessing the damage to functional group of proteins and the oxidative balance in this group of patients.
Design, patients and measurements: Thirty-five patients with a new diagnosis of hypothyroidism due to HT who were not yet under treatment is enrolled in the study. Serum samples were taken prior to the treatment and 6 months after initiation of levothyroxine sodium treatment to compare clinical and laboratory parameters of patients. Thiol/disulfide homeostasis is evaluated by Erel & Neselioglu method.
Results: After 6 months of treatment the native thiol and total thiol levels were significantly increased (P=0.001 and P=0.001). The disulphide level, the disulphide/native thiol and the disulphide/total thiol ratios showed a significant decline (P=0.001, P=0.001, P=0.001 respectively).
Conclusion: Decrease in the disulfide/thiol ratio after levothyroxine sodium treatment in hypothyroidism may suggests that treatment plays a role in reducing both oxidative stress and free radical mediated damage to the functional groups of proteins. Thus, it may be possible to avoid the complications caused by oxidative stress. As a result disulfide/thiol ratio may contribute to the management of treatment in hypothyroid patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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