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Endocrine Abstracts (2017) 49 EP1370 | DOI: 10.1530/endoabs.49.EP1370

ECE2017 Eposter Presentations: Thyroid Thyroid (non-cancer) (260 abstracts)

The role of preoperative serum thyroglobulin values in the diagnosis of differentiated thyroid cancer

Blertina Dyrmishi 1 , Taulant Olldashi 1 , Ema Lumi 2 , Entela Puca 3 , Dorina Ylli 4 , Majlinda Ikonomi 1 & Thanas Fureraj 4


1Hygeia Hospital Tirana, Tirana, Albania; 2Regional Hospital Korca, Korca, Albania; 3Neo Style Clinic, Tirana, Albania; 4UHC “Mother Teresa”, Tirana, Albania.

Introduction: Thyroglobulin (TG) is the most important protein produced by the thyroid. TG is considered a reliable marker of recurrent disease in patient with differentiated thyroid carcinoma (DTC). Before surgery, high serum TG values may be due to an abnormally large thyroid, excessive thyroid stimulation, or physical damage to thyroid etc.

Methods: We evaluated in the retrospective study 20 patients (mean age 49.6±12 S.D., range from 25–73 years old), with a histological diagnosis of DTC. Clinical diagnosis before surgery was: 20% (4) solitary nodule; 10% (2) hyperthyroidism; 5% (1) thyroid cancer with lytic bone metastasis; 65%(13) non toxic multinodular goiter.

Results: Histological diagnosis: 85% (17) papillary thyroid cancer, and 15% (3) cases with follicular thyroid carcinoma. 25% (5) cases with micro DTC and 75% (15) of cases with DTC more than 1 cm. We excluded from study one case with large lytic bone metastasis because the serum TG value was very high 11096 ng/ml. Mean TSH values were 1.4±0.9 IU/ml and mean TG values was 88.1±67 ng/ml (range 16.7–255 ng/ml). In 20% (4) of cases with DTC less than 1 cm TG values it were in the normal range. In 14 patients with DTC bigger than 1 cm: 42% (6) of cases had TG values more than 2 fold of normal range, 28% (4) of cases had TG values in the normal range and 28% (4) of cases had TG values between normal and two fold normal range.

Conclusions: In our study TG are more sensitive to detect DTC macro carcinoma, but we need to evaluate more cases, to compare TG values in cases with negative biopsy and to evaluate even the TG antibodies.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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