Endocrine Abstracts

Introduction: The aim of this study was to investigate the incidence of glycemic disorders in patients undergoing coronary angiography with no prediagnosed type 2 diabetes (T2D), as well as the association of the glycemic status with the extent of the coronary artery disease (CAD).

Patients and methods: We studied 170 consecutive patients (134M/36W), 63.9±13.1 (23–95) years old, with not known T2D, who underwent coronary angiography. HbA1c was measured and patients were classified into 3 groups accordingly: i) normal HbA1c<5.7%, ii) prediabetes HbA1c 5.7–6.4%, and iii) T2D HbA1c ≥6.5%. The presence of other risk factors for CAD was recorded, while the extent of CAD was examined. Vessel disease (VD) was defined when stenosis was >70%.

Results: From the total of 170 patients, 19.4% (33/170) presented normal HbA1c, 17.6% (30/170) prediabetes and 63% (107/170) were diagnosed with T2D. Patients with normal HbA1c were 60.5±16.7 years old, with BMI 29.1±5.2, 18.2% (6/33) were women, 48.5% (16/33) had hypertension, 36.4% (12/33) dyslipidemia, while 21.2% (7/33) had history of CAD. Of these, 33.3% (11/33) showed no VD, 33.3% (11/33) one VD 21.2% (7/33) two VD, 6% (2/33) three VD and 6% (2/33) left main along with another one VD. Patients with prediabetes were 65.9±11 years old, with BMI 29.6±5.1, 6.7% (2/30) were women, 63.3% (19/30) had hypertension, 43.3% (13/30) dyslipidemia and 20% (6/30) had history of CAD. Of these, 30% (9/33) showed no VD, 30% (9/30) one VD, 6% (5/30) two VD and 23.3% (7/33) three VD. Patients with T2D were 64.4±12 years old, with BMI 23.8±2.6, 26.2% (28/107) were women, 69.2% (74/107) had hypertension, 52.3% (56/107) dyslipidemia, while 24.3% (26/107) had history of CAD. Of them, 42.1% (54/107) showed no VD, 27.1% (29/107) one VD, 17.8% (19/107) two VD, 11.2% (12/107) three VD and 1.9% (2/107) left main along with another one VD.

Conclusion: Prediabetes and T2D were detected in the majority of patients undergoing coronary angiography without previously known glycemic disorders. Therefore, HbA1c should be determined in all patients hospitalized for possible CAD, regardless of the history for diabetes.