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Endocrine Abstracts (2017) 49 EP470 | DOI: 10.1530/endoabs.49.EP470

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1Institute of Physiology, School of Medicine, University of Belgrade, Belgrade, Serbia; 2Clinic for Endocrinology, Diabetes and Metabolic Diseases, School of Medicine, University of Belgrade, Belgrade, Serbia; 3Institute of Forensic Medicine, University of Belgrade, Belgrade, Serbia; 4Clinics for Pulmology, Clinical Center of Serbia, Belgrade, Serbia.


It has been shown that low values of insulin sensitivity have been related to metabolic diseases. Exercise prescription is crucial to prevent low insulin sensitivity in general population, and athletes are good physiological model. If this assumption is correct, examine insulin sensitivity in elite athletes should reflect the positive effect of exercise on insulin sensitivity. The aim of this study was to investigate the effects of regular exercise on insulin sensitivity estimated by HOMA model in elite athletes, as well as the possible relationship the insulin sensitivity with body composition. Sixteen low fat athletes (LFAG, BF<12%), 15 high fat athletes (HFAG, BF≥12%) and 15 sedentary subjects participated in study. The subjects underwent to an assessment of body composition. All subjects were exposed to one bout exercise test on treadmill in order to examine acute changes of insulin response. Blood samples were obtained at rest, immediately after the exercise test and 30 minutes after recovery. Separated serum were used for insulin ELISA analysis and glucose levels. Insulin resistance index (HOMA-IR) was calculated. At rest, LFAG had significantly lower insulin compared to control group (P<0.05). Also, there were no statistically differences in basal level of glycaemia and HOMA index between groups. In all three study groups insulin levels were higher immediately after an acute bout of exercise compared to baseline values (P<0.05), and remained equal (LFAG, P<0.05 compared to baseline) or even higher (P<0.05, HFAG, P<0.05, controls) in recovery. There is no significant correlation between the parameters of body composition and HOMA-IR in all groups. In conclusion, our findings show that insulin respond to acute exercise depends on body composition. Acute exercise elicited higher insulin response in HFAG and controls. Also, these results suggest that chronic exercise dose not altered insulin sensitivity estimated by HOMA model in elite athletes.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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