Endocrine Abstracts (2017) 49 EP555 | DOI: 10.1530/endoabs.49.EP555

Dyslipidaemia and diabetes: a real world clinical evidence in Indian scenario

Shantharam Duvvuru, Sambit Das, SG Moazam, N Rajendiran, S Venkataraman, NK Narayanan, AV Bhanu Keerthi, Vamsi Krishna Kolukula & Shashank Joshi

Apollo Sugar Clinics, Hyderabad, India.

Background: Dyslipidaemia, a major risk factor for cardiovascular disease (CVD) is considerably increasing in patients with diabetes. The purpose of the study was to evaluate the lipid profiles of diabetes patients attending Apollo Sugar Clinics across India.

Methods: The current study was a retrospective analysis of electronic medical records of 1487 type 2 diabetes (T2DM) patients who registered at (Dec 2014 to Oct 2016) Apollo Sugar Clinics, across India. Patients with diabetes were diagnosed as per the ADA guidelines, and the data was collected from the patients after signing informed consent. Statistical analysis was done by using SPSS version 20, and a 2-tailed P ≤0.05 was set to be significant.

Results: In total (N=1487) T2DM patients, males and females were 64.9% and 35.1%, respectively and had mean (SD) age 53.0 (10.6) years. Of these patients analysed, 54.8% had high low density lipoprotein (LDL; >100 mg/dl), 86.1% had low high density lipoprotein (HDL; <50 mg/dl), 40.7% had hypercholesterolemia (>180 mg/dl) and 76.3% had hypertriglyceridemia (>100 mg/dl). In low HDL group of 86.1%, 54.3% had high LDL and 79% had high TG. Further, mean concentrations of LDL (111.1 vs 105.6; P=0.01), HDL (43.3 vs 38.9; P<0.001), and TC (177.9 vs 169.2; P<0.001) were significantly higher in females compared to males (P ≤0.01). However, of these patients 45.2% and 59.3% are at LDL and TC targets, respectively.

Conclusions: The prevalence of dyslipidaemia was observed to be high in diabetes patients than reported in normal population. The pattern of dyslipidaemia is different in India which is termed as ‘atherogenic dyslipidaemia’ where, in addition to low HDL, there were elevated levels of both TG and LDL. This increases morbidity of non-communicable disease and needs multifactorial intervention for primary prevention of CVD in diabetes.

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