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Endocrine Abstracts (2017) 49 EP556 | DOI: 10.1530/endoabs.49.EP556

1Republican Scientific and Practical Center for Radiation Medicine and Human Ecology, Gomel, Belarus; 2Gomel State Medical University, Gomel, Belarus.


Given the significant correlation between the indices of lipid metabolism, liver dimensions, glycated hemoglobin and indicators cytolysis of hepatocytes identified a number of predictors that have had a significant influence on the formation of NAFLD. At a BMI above 26.5 kg/m2, the relative risk (RR) for BMI was 20.02 and was statistically significant (8.25÷48.61). When VLDL level above 0.6 mmol/l relative risk for NAFLD also was statistically significant (RR=28.50; 11.18÷72.65). With increasing levels of triglycerides above 1.43 mmol/l relative risk for NAFLD was 34.69 and was statistically significant (12.68÷94.91). In the course of the factor analysis, we analyzed the contribution of isolated predictors in the development of NAFLD patients with diabetes. So with type 2 diabetes have made the contribution to such predictors as a BMI (65.4%), and increase level of triglycerides (16.85%), while type 1 diabetes - BMI (65.4%) and the level of VLDL (81.0%). In type 2 diabetes the leading influence obesity and atherogenic focus lipogenesis. Patients with type 1 diabetes on the development of obesity affects both NAFLD and associated levels of atherogenic lipids, and the degree of compensation of carbohydrate metabolism and associated level of glycation of proteins.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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