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Endocrine Abstracts (2017) 49 EP559 | DOI: 10.1530/endoabs.49.EP559

1Department of Endocrinology and Metabolic Diseases, University of Thessaly, Larissa, Greece; 2General Hospital of Larissa, Larissa, Greece; 3Department of Endocrinology, University of Ioannina, Ioannina, Greece; 4Department of Radiology, University of Thessaly, Larissa, Greece.

Introduction: Existing data suggest that Type 1 Diabetes Mellitus (T1DM) can affect both hypothalamic-pituitary-testis axis and bone health. The mechanisms by which sex steroids influence bone remodeling remain incompletely understood. Data linking gonadal function and bone turnover in male patients with T1DM are lacking. The purpose of this study was to examine any possible association between sex steroids levels and parameters of bone assessment in male adult patients with T1DM.

Methods/design: We studied 53 male patients with T1DM (Group-D) and 42 healthy controls (Group-C) matched for age, sex and BMI. In both groups HbA1c, Inhibin B (InhB), total testosterone (TT), SHBG, LH, FSH, β-crosslaps, type 1 procollagen total N-terminal propeptide (TP1NP) and BMD at lumbar spine (LS), femoral neck (FN) and total hip (TH) by dual energy X-ray absorptiometry (DXA) were measured.

Results: Mean age (years) (D: 34.9+10.6 vs C: 34.1+9.9, P=0.41) and BMI (kg/m2) (D: 23.7+8.1 vs C: 24.5+7.7, P=0.38) were similar in both groups. In Group-D, mean duration of DM was 14.4+8.5 years and mean HbA1c was 7.8+1.3%. Higher levels of FSH (P=0.043) and SHBG (P=0.041), and a trend towards lower InhB (P=0.049) and TT (P=0.051) concentrations, were observed in Group-D compare to controls. LH was similar in both groups (P=0.069). Total BMD (tBMD, g/cm2) and z-scores were lower in Group-D at all three sites ((LS: P=0.031 and P=0.036), (FN: P=0.042 and P=0.039), (TH: P=0.046 and P=0.044)). No significant difference in β-crosslaps (P=0.080) and TP1NP (P=0.086) was found between the two groups. Regression analysis showed: a negative association between InhB and HbA1c (P=0.038), InhB and tBMD at LS (P=0.041) and a positive association between InhB and β-crosslaps (P=0.044) and InhB and TP1NP (P=0.047).

Conclusion: These data suggest that InhB might contribute to bone turnover changes observed in T1DM. Further studies are needed.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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