Endocrine Abstracts (2017) 49 EP666 | DOI: 10.1530/endoabs.49.EP666

Comparison between mathematical indexes and histopathological findings in the diagnosis of nonalcoholic fatty liver disease in mexican population

Karen-Ivette Gutierrez-Aguirre1, Maria-Luisa Lazo-de-la-Vega-Monroy1, Yeniley Ruiz-Noa1, Lorena-del-Rocio Ibarra-Reynoso1, Juana-Rosalba Garcia-Ramirez2, Benjamin Jordan-Perez2, Serafin Garnelo-Cabañas2 & Monica-del-Carmen Preciado-Puga1

1University of Guanajuato, Leon, Guanajuato, Mexico; 2Hospital General Leon, Leon, Guanajuato, Mexico.

Introduction: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease in Mexico, comprising a spectrum of histopathological findings ranging from simple steatosis to steatohepatitis and cirrhosis. The gold standard continues to be the liver biopsy, but several mathematical indices have been proposed, such as non-invasive techniques, however there are very few studies in our population.

Objetive: This study aims to compare mathematical indexes and histopathological findings for the detection of NAFLD in Mexican population.

Methods: A cross-sectional study was performed at the ‘Hospital General León’ between November 2016 and January 2017. Patients aged 18 years or above that underwent laparoscopic cholecystectomy were recruited. No history of alcohol consumption habit or hepatic diseases characterized the patients. The fatty liver index (FLI) and the lipid accumulation product (LAP) were calculated. Demographics, blood samples, and a liver biopsy were obtained. Results between FLI, LAP and livery biopsy were compared.

Results: A total of 59 patients were included (80.1% women and 19.1% men). The mean age was 39.6±14.8 years, BMI 29.7±10.11 kg/m2. The FLI identified 31 patients with NAFLD of which 11 were corroborated with biopsy, whereas the LAP identified 26 patients of which 17 were corroborated with biopsy. From the patients with negative FLI index (n=26), a total of 11 (42%) were diagnosed with steatosis by histopathology. For LAP, 31 patients (54.3%) were negative, four of which (7.01%) presented positive for NAFLD by histopathological diagnosis.

Conclusion: According to our results, at least in our population these two mathematical indices are not useful for the diagnosis of NAFLD, so liver biopsy remains to be the gold standard for the detection of NAFLD. Future studies should be performed in order to continue looking for other non-invasive markers for NAFLD.