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Endocrine Abstracts (2017) 49 EP885 | DOI: 10.1530/endoabs.49.EP885

1Pediatric Endocrinology Unit, 3rd Department of Pediatrics, University General Hospital Attikon, Athens, Greece; 2Haemophilia Center – Haemostasis and Thrombosis Unit, Aghia Sophia Children’s Hospital, Athens, Greece; 3Biochemistry-Hormonology Department, P and A Kyriakou Children’s Hospital, Athens, Greece.

Background: Increased fibrinogen levels have been reported in prepubertal children and adolescents with growth hormone deficiency (GHD), which were reduced after rhGH treatment. rhGH treatment has also been shown to exert a beneficial effect on the amount of aPAI-1 in children with GHD. Aim of the study was to evaluate whether prepubertal GH deficient (GHD) children showed any impairment in coagulation- and fibrinolysis-related parameters and the effect of GH therapy on these parameters.

Patients and methods: Fifteen prepubertal children (ten girls and five boys) of a mean (S.D.) age of 9.8 (0.4) yrs with GH deficiency were included in this hospital based prospective study. Serum levels of PT, APTT, fibrinogen, VII, VIII, AT, PC, D-dimers, Plg, and PAI-1 were measured before and after 6-12 months of GH treatment.

Results: At baseline all studied parameters were within normal ranges. A significant increase in PT values was noted after a mean (S.D.) interval of 9.3 (0.4) months of treatment: 12.46 (0.2)sec vs 12.1(0.15)sec, P=0.045. A significant decrease in PAI-1 levels (3.04 (0.1) U/ml vs 2.28 (0.3) U/ml, P=0.018) was noted at the same time. No significant changes in the rest of parameters were found during the study period.

Conclusion: GH replacement therapy for 6–12 months led to a significant increase in PT values, while fibrinogen levels did not change. Moreover, GH treatment reduced PAI-1 levels in GHD children, suggesting a beneficial effect of GH treatment on possible risk of future atherothrombosis. Further evaluation of the clinical significance of these changes is needed.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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