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Endocrine Abstracts (2017) 49 EP896 | DOI: 10.1530/endoabs.49.EP896

ECE2017 Eposter Presentations: Pituitary and Neuroendocrinology Neuroendocrinology (33 abstracts)

Bilateral inferior petrosal sinus sampling and the outcome of transsphenoidal surgery in patients with Cushing’s disease: experience of a Tertiary Portuguese Hospital

Ana Coelho Gomes 1 , Lia Lucas Neto 2 , Francisco Tortosa 3 , Maria Raquel Carvalho 1 , Eduardo Barreiros 1 , Luís Barreiros 1 , José Miguéns 4 & Maria João Bugalho 1


1Endocrinology, Diabetes and Metabolism Department, Santa Maria Hospital, Lisbon, Portugal; 2Neuroradiology Department, Santa Maria Hospital, Lisbon, Portugal; 3Pathology Department, Santa Maria Hospital, Lisbon, Portugal; 4Neurosurgery Department, Santa Maria Hospital, Lisbon, Portugal.


Introduction: Bilateral inferior petrosal sinus sampling (BIPSS) is the gold-standard for the differential diagnosis of ACTH-dependent Cushing Syndrome when the pituitary adenoma on MRI is doubtful or absent. This study aimed to analyze whether BIPSS can influence the outcome in patients with Cushing disease (CD).

Methods: Retrospective, descriptive study. Forty-two patients with CD submitted to transsphenoidal surgery (TS) between 2005 and 2016 were divided into two groups based on the performance of BIPSS. Different variables were analyzed: year of diagnosis, preoperative laboratory tests and pituitary MRI, immediate postoperative laboratory tests, histological findings, postoperative hypopituitarism, presence of permanent diabetes insipidus, follow-up duration and final outcome.

Results: Ten out of forty-two patients with CD were submitted to BIPSS.

Discussion: Groups were different in terms of the preoperative imaging. For the other variables, no differences were observed. The final outcome, despite the higher number of macroadenomas in the group without BIPSS was not statistically different. Results await further confirmation.

BIPSSNo BIPSSp-value
Diagnosis Year (%): 1995–2000 / 2001–2010 / >20100/70/309/47/440.355
Preoperative sellar MRI (%): Microadenoma / Macroadenoma / Indeterminate Lesion / No Image20/0/30/5066/16/0/6<0.01
Preoperative Laboratory Tests (%): Classical / Non-Classical100/059/130.159
Immediate Postoperative Laboratory Tests (%): Criteria for Cure / No Criteria for Cure40/4041/411
Histology (%): Adenoma / Corticotroph Hyperplasia / Normal tissue60/10/3078/3/90.462
Postoperative anterior pituitary deficiency (%): Isolated / Multiple / None20/20/2028/25/440.713
Permanent Diabetes Insipidus (%): Yes / No0/1006/940.418
Mean Follow-Up (years)5.7±3.8 (0–11)6.8±5.1 (1–21)0.544
Final Outcome (%): Remission / Active Disease70/3047/500.386
Note: In some parameters the sum of the partial percentages is not 100% because some patients didn’t have that information.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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