ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2017) 51 S3.1 | DOI: 10.1530/endoabs.51.S3.1

Nephropathy - What have we learned from AdDIT?

David Dunger


Cambridge.


Introduction: The Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) is a collaboration across 32 sites in Canada, Australia and the United Kingdom exploring the early detection and prevention of complications in adolescents with type 1 diabetes.

Methods: Over 4,000 young people aged 10–16 years were screened to identify 450 high risk (based on urinary albumin excretion) for a randomised controlled trial (RCT) of statins and ACE inhibitors and 400 low risk subjects for an observational study over 2–4 years.

Results: The results of the RCT, which will be published in 2017 will be reported together with recent analysis of the combined AdDIT cohort of 850 subjects.

Discussion / Conclusion: Implications for early risk stratification and later strategies for prevention of complications will be discussed.

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