Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ePoster Presentations

Pituitary and Neuroendocrinology

ea0056ep100 | Pituitary and Neuroendocrinology | ECE2018

Characteristics of clinical and morphological features of functioning and nonfunctioning pituitary adenomasand disorders commonly associated with them

Tulabaite Kotryna , Splitaite Anna , Abraitiene Agne , Zelnyte Gintare

Background: The prevalence of pituitary adenomas (PAs) is increasing as the development of imaging techniques. The objective of this study is to assess the clinical and morphological features of non-functioning, prolactin, and grown-hormone secreting pituitary adenomas and to analyze the accompanying diseases of each condition.Methods: A retrospective analysis of the clinical records of patients with non-functioning (NFPA), prolactin (PRL+) or grown horm...

ea0056ep101 | Pituitary and Neuroendocrinology | ECE2018

Prolactinoma management: factors that might predict remission of the disease after 12 months of treatment

Splitaite Anna , Tulabaite Kotryna , Abraitiene Agne , Zelnyte Gintare

Background: Dopamine agonists (DAs) are the primary treatment for both microprolactinomas and macroprolactinomas. Two medications are FDA approved for the medical treatment of prolactinomas: cabergoline and bromocriptine. Although bromocriptine is deemed a secondary option after cabergoline, its lower cost may be a consideration for some patients. The purpose of this study is to analyze patients treated with different DAs during 12 months period and to identify the unchangeabl...

ea0056ep102 | Pituitary and Neuroendocrinology | ECE2018

A differentiated approach to the treatment of pituitary apoplexy

Kutin Maxim , Kalinin Pavel , Fomichev Dmitriy , Sharipov Oleg , Astafyeva Liudmila

Introduction: The risk of pituitary apoplexy (PApopl) is up to 9.5%. In 80% of cases, it is the first manifestation of the disease.Material and methods: The study included 94 PApopl from 1 day up to 9 years. Conservative treatment was performed in 37 cases, and 59 were operated on including 14 giant posthemorrhagic cysts. The probability of resorption – it is possible in 85%, instead of cysts (the probability of resorption of ~ 15%). After 3 months,...

ea0056ep103 | Pituitary and Neuroendocrinology | ECE2018

Unusual association: turner syndrome and anterior pituitary insufficiency in 6 cases

Safi Wajdi , Kacem Faten Hadj , Moalla Mariem , Ghorbel Dorra , Mnif Fatma , Feki Mouna Mnif , Rekik Nabila , Belghith Neila , Abdelhedi Fatma , Kacem Hassen Hadj , Abid Mohamed

Introduction: Turner syndrome (ST) affects 1/2500–1/4000 of female births, its association with congenital malformations is traditional, however the coexistence of hypopituitarism is exceptional. In this context, we report 6 patients; including 3 belonging to the same family and in whom the association of anterior pituitary insufficiency (IAH) to a ST was confirmed.Results: The average age of our patients was 17.2 years (11–31). The ST was sele...

ea0056ep104 | Pituitary and Neuroendocrinology | ECE2018

Evaluation of differential diagnosis and treatment stages of TSH-secreting pituitary microadenoma which responding to cabergoline therapy

Cander Soner , Gul Ozen Oz , Gunes Elif , Ersoy Canan , Erturk Erdinc

Introduction: High thyroid hormone levels with unsupressed TSH (atypical hyperthyroxinemia) is one of the difficult endocrinologic conditions. When the conditions leading to euthyroid hyperthyoxinism are excluded, TSH secreting pituitary adenomas (TSHoma) and thyroid hormone resistance beta syndrome (THRB) lead to this picture as rare diseases. This report aims to evaluate the diagnostic and therapeutic stages in the case of TSH-secreting pituitary microadenoma which response ...

ea0056ep105 | Pituitary and Neuroendocrinology | ECE2018

Case presentation: Double non-functioning pituitary adenomas

Sisman Pinar , Gul Ozen Oz , Cander Soner , Ersoy Canan , Erturk Erdinc

Background: Pituitary adenomas are usually benign epithelial tumors and they are the most common cause of sellar masses from the third decade on, accounting for up to 10% of all intracranial neoplasms. Pituitary adenomas typically present with neurologic symptoms, clinical findings of hormonal abnormalities or as an incidental finding on magnetic resonance imaging (MRI). Double pituitary adenomas are very rare, and they account for 1% of all pituitary adenomas in autopsy serie...

ea0056ep106 | Pituitary and Neuroendocrinology | ECE2018

Rare combination of Acromegaly and Klinefelter syndrome

Sagova Ivana , Pavai Dusan , Stancik Matej , Kantarova Daniela , Urbankova Helena , Gregova Juliana , Vanuga Anton , Vanuga Peter

Acromegaly is a rare disorder usually caused by a benign tumour of the pituitary gland. Long-term presence of elevated growth hormone (GH) and insulin like growth factor I (IGF-I) levels accompanying this disease is associated with complications such as heart failure, cerebrovascular disease, diabetes mellitus, sleep apnoea and arthropathy. Incidence of acromegaly is 3-5 patients per million per year. Klinefelter syndrome is ...

ea0056ep107 | Pituitary and Neuroendocrinology | ECE2018

Could it be recurrent immunoglobulin G4-associated inflammatory mass at the hypothalamic region?

Erdem Soyaltin Utku , Simsir Ilgin Yildirim , Yurekli Banu Sarer , Saygili Fusun

Case: Thirty seven years old patient whose complaint was head ache was seen in the out patient clinic for the follow up of her hormone replacement therapy. First time she was admitted to hospital with the complaint of confusion was in 2013. Her cranial MRI revelaed enlargement of optic chiasma with the possible diagnossis of optic chiasmatic glioma. Biopsy was taken out from this mass twice in July and November of 2013. In histological examinations, there were B and T lymphocy...

ea0056ep108 | Pituitary and Neuroendocrinology | ECE2018

Rheumatoid arthritis, acromegaly, primary hyperparathyroidism – what’s next?

Nistor Irina Manuela , Pascu Raluca Cristina , Lambrescu Ioana Maria , Fica Simona

Introduction: Rheumatoid arthritis is an inflammatory disease characterized by joint destruction, the erosion being caused by invasion of articular cartilage by the synovial pannus. This chronic systemic disease affects approximately 0.5–1% of the adult population, occurring more often in women than in men (3:1). The etiology is thought to be multifactorial, environmental factors or infectious agents being suggested to play a role, but their contribution is yet to be defi...

ea0056ep109 | Pituitary and Neuroendocrinology | ECE2018

Ectopic clival prolactinoma with empty sella in a patient using antipsychotic

Gen Ramazan , Ozgur Anil

Prolactinoma is the most common cause of chronic hyperprolactinemi and drugs that rise serum prolactin levels have been ruled out. Altough almost all of them arise within the sella turcica, there are some rare cases in which prolactinoma is located outside the intrasellar region, so it is defined as ectopic prolactinoma. Neuroleptics (e.g., haloperidol, chlorpromazine, risperidone.) can elevate serum PRL to levels that usually are detected with prolactinomas. We report a case ...

ea0056ep110 | Pituitary and Neuroendocrinology | ECE2018

Clinical profile of patients with hyperprolactinemia: a study based on nepalese population

Joshi Ansumali , Yonzon Priyadarshini

Background: Hyperprolactinemia is a common endocrine disorder. Yet, data on clinical profile of Nepalese patients with hyperprolactinemia is missing. The aim of this study was to assess the clinical profile of Nepalese patients with hyperprolactinemia.Methodology: Retrospective clinic based study conducted at the endocrine centre Kathmandu Diabetes and Thyroid Center, Lalitpur, Nepal, in which data was collected from the patient record files of the subje...

ea0056ep111 | Pituitary and Neuroendocrinology | ECE2018

GSP gene mutation in a sample of Iraqi acromegalic patients and their response to long-acting repeatable octerotide

Rahmah Abbas , Sami Assel , Abbas Wathiq

Patients and methods: 190 acromegalic patients are registered in the National Diabetes Center, 60 were enrolled in the study. They were randomly selected by simple sampling technique according to their scheduled visits monthly to receive - long acting repeatable octreotide injections (LAR).Results: Table 1 Demographic data of the enrolled acromegalic patients.</c...

ea0056ep112 | Pituitary and Neuroendocrinology | ECE2018

Quality of life of patients with active acromegaly which didn’t underwent surgery

Boskovic Olivera , Kovacevic Zlata , Muzurovic Emir , Vujosevic Snezana

Acromegaly is chronic disease caused by hypersecretion of growth hormone (GH), most common caused by adenoma of pituitary gland. Cardiovascular risk, respiratory complication and malignancy are more common in this patients. Most often onset is between 30 to 50 years old, equally between gender. Therapy is almost always surgery, it can be combined with radiotherapy and gamma knife. Medicament therapy with somatostatin analogues, dopamine agonists and GH receptor antagonist. Goa...

ea0056ep113 | Pituitary and Neuroendocrinology | ECE2018

Serum concentration of insulin-like growth factor I (IGF-I): reference values for adult Romanian population: Preliminary results

Alexandru Niculescu Dan , Dobre Ramona , Caragheorgheopol Andra , Popescu Nicoleta , Poiana Catalina

Background: Growth hormone, age, sex, genetics or nutrition status play an important role in insuline-like growth factor 1 (IGF-1) liver production and serum levels. Currently, there is no IGF-I reference range for Romanian population.Aim: To define sex- and age-adjusted reference values for serum IGF-I measured by an automated chemiluminescence immunoassay in adult Romanian population of healthy subjects.Methods: The study include...

ea0056ep114 | Pituitary and Neuroendocrinology | ECE2018

Hyponatremia as a first symptom of hypopituitarism due to pituitary metastasis of gastric cancer: Case study

Zwolak Agnieszka , Lewicki Marcin , Tywanek Ewa , Swirska Joanna , Dudzinska Marta , Tarach Jerzy

Introduction: Hypopituitarism can be caused by a number of different etiologic factors including metastatic cancer. Metastasis to the pituitary gland is rare, accounting for only 1.8% of all metastases, and is often detected incidentally by symptoms associated with hormone dysfunction like hyponatremia. Breast and lung cancer are the primary neoplasms with well established properties of pituitary infiltration. Metastases from gastric cancer are unusual and constitute less than...

ea0056ep115 | Pituitary and Neuroendocrinology | ECE2018

Macroprolactinemia diagnosed in a patient evaluated for primary infertility

Nogueira Claudia , Cunha Filipe , Ferreira Ivan , Mesquita Joana

Introduction: Hyperprolactinemia is associated with suppression of the hypothalamic-pituitary-gonadal axis and it’s a frequent cause of infertility, occurring in about 30–40% of infertile women. The bioactive fraction of prolactin is a 23-kDa monomer. However, there are other isoforms with reduced or absent bioactivity, such as macroprolactin, which can be detected by the precipitation reaction by polyethylene glycol. Macroprolactinemia should be suspected in the pre...

ea0056ep116 | Pituitary and Neuroendocrinology | ECE2018

Clinical characteristics and management of 4 patients with chordomas of the skull base attending Beaumont Hospital

Maria Tudor Roxana , Forde Hannah , Agha Amar , Faul Clare , Javadpour Mohsen

Introduction: Chordomas are rare slowly growing locally aggressive neoplasms of the bone arising from embryonic remnants of notochord. These tumours typically occur in the axial skeleton and have a proclivity for the spheno-occipital region of the skull base. Parasellar/clivus chordomas account for one third of all chordomas.Methods: We conducted a retrospective chart review of 4 patients with chordomas of the clivus treated in Beaumont Hospital between ...

ea0056ep117 | Pituitary and Neuroendocrinology | ECE2018

GH/TSH secreting adenoma: a clinical case report: GH/TSH secreting adenoma: a clinical case report

Tarasova Tatiana , Lutsenko Alexander , Przhiyalkovskaya Elena , Pigarova Ekaterina , Dzeranova Larisa , Tiulpakov Anatoly , Dedov Ivan

Case description: A 26-year-old female visited an endocrinologist for the first time in 2014 with complaint of neck swelling. Lab results revealed increased blood level of TSH, initially the diagnosis of hypothyroidism was set and levothyroxine therapy was initiated with consequent addition of thiamazole due to increasing levels of free T4 and TSH. In 2015 the diagnosis of TSH-secreting adenoma was made on the basis of MRI findings (pituitary microadenoma 3.1 mm in size) and l...

ea0056ep118 | Pituitary and Neuroendocrinology | ECE2018

Antiphospholipid syndrome and pituitary necrosis

Jemel Manel , Sayadi Hanene , Khochtali Ines

Introduction: Antiphospholipid syndrome (APS) is an acquired thrombotic disorder. It mainly occurs with systemic disease or as a primary disorder. All organs may be involved by thrombosis. But endocrine disorders seen in antiphospholipid syndrome are rare. In the literature, rare cases of hypopituitarism with APS have been reported.The observation: It is a 27 years old patient who consults for headache with diplopia. The interview underlines galactorrhea...

ea0056ep119 | Pituitary and Neuroendocrinology | ECE2018

A rare emergency case in endocrinology: pituitary apoplexy

Gorar Suheyla , Cagri Turk Cezmi , Gediz Tolga , Inal Gulsah

Introduction: Pituitary apoplexy is a relatively rare clinical emergency in endocrinology. It results from hemorrhage or infarction in the pituitary gland. This clinical state is characterized headache, vomiting, visual defects, and signs of meningeal irritability.Case: 22-years-old woman was referred to hospital because of predicted haemorrhagic or cystic pituitary adenom in magnetic resonance imaging (MRI). She was married but not a child. She had mens...

ea0056ep120 | Pituitary and Neuroendocrinology | ECE2018

Macroprolactinoma found in obesity setting: case report

Sofia Osorio Ana , Filipa Martins Ana , Vieira Joao , Barbosa David , Faria Carolina , Nobre Ema , Joao Bugalho Maria

Obesity is growing fast worldwide. Although environmental factors play a major role, endocrine dysfunction may contribute to the weight gain. We report an invasive macroprolactinoma diagnosed in obesity setting. A 35-year-old male was referred to our endocrine outpatient department due to grade 2 obesity (IMC 38.4 Kg/m2). His weight was increasing since the beginning of his professional activity at the age of 20 due to a sedentary lifestyle. On physical examination he had an h...

ea0056ep121 | Pituitary and Neuroendocrinology | ECE2018

Emotional disorders in patients with tumors of diencephalic localization

Sidneva Yuliya , Astafyeva Liudmila , Zaitsev Oleg , Kalinin Pavel , Kutin Maxim , Klochkova Irina

Among tumors of the diencephalic region there are: pituitary adenomas, craniopharyngiomas, gliomas, meningiomas and others. They differ in location, histology, clinic with corresponding hormonal disorders. Emotional disorders in the clinic of tumors of the diencephalic region are revealed in 2–67% by the literature. Emotional disturbances with hormone-active pituitary adenomas there are 30–60%, and with non-functioning pituitary adenomas there are ones less than 6%. ...

ea0056ep122 | Pituitary and Neuroendocrinology | ECE2018

Clinical improvement of hyperglycemia after use of octreotide lar in a patient with acromegaly who presented with nonketotic hyperosmolar state

Cavdar Umit , Ozdemir Nilufer , Aycicek Bercem , Diri Halit

A 37-year-old patient with a history of transcranial pituitary surgery because of acromegaly was referred to our clinic with the glucose level 731 mg/dl. she was not using any medication. There was no ketone in the urine and HbA1c was 18.6%. She has 17×16×15 mm of residual macroadenoma on pıtuıtary MRI with level of GH 17.5 ng/ml and IGF-1 422 ng/ml. She was using 140 units of insulin glargin U300 and 100 units of insulin regular per a day before octreotide...

ea0056ep123 | Pituitary and Neuroendocrinology | ECE2018

Frequency of associated diseases in risk groups of a syndrome of Cushing in the Khorezm, Namangan and Kashkadarya regions of the Republic of Uzbekistan

Khalimova Zamira , Urmanova Yulduz , Narimova Gulchekhra , Alimukhamedova Gulrukh , Safarova Shokhsanam

Tashkent Pediatric Medical Institute, department of endocrinology, Center of the Scientific and Clinical Study of Endocrinology, department of neuroendocrinoloy, Ministry of Health of the Republic of Uzbekistan. Republic of Uzbekistan, 100125, Tashkent, Mirzo Ulugbek str. 56Z. Yu. Khalimova, G.D. Narimova, Yu.M. Urmanova, G/O/ Alimukhamedova. Sh.M. SafarovaThe aim: To study the characteristic of associated diseases in risk groups o...

ea0056ep124 | Pituitary and Neuroendocrinology | ECE2018

The characteristic of the index of body weight in risk groups of a syndrome of Cushing in the Khorezm, Namangan and Kashkadarya regions of the Republic of Uzbekistan

Narimova Gulchekhra , Khalimova Zamira , Urmanova Yulduz , Alimukhamedova Gulrukh , Narimova Malika , Safarova Shokhsanam

Tashkent Pediatric Medical Institute, department of endocrinology, Center of the Scientific and Clinical Study of Endocrinology, department of neuroendocrinoloy, Ministry of Health of the Republic of Uzbekistan. Republic of Uzbekistan, 100125, Tashkent, Mirzo Ulugbek str. 56G.D Narimova., Z.Yu. Khalimova, Yu.M. Urmanova, M.I. Narimova, Sh.M. Safarova, G.O. AlimukhamedovaThe aim: To study the characteristic of the index of body weig...

ea0056ep125 | Pituitary and Neuroendocrinology | ECE2018

Dynamics of indicators of the questionnaire of QoL AGHD at assessment of quality of life at patients after 3 months and 6 months after operation of transnasal pituitary adenomectomy by the replacement treatment growth hormone Djintropin

Urmanova Yulduz , Shakirova Mukhlisa

Tashkent Pediatric Medical Institute, department of endocrinology, Center of the Scientific and Clinical Study of Endocrinology, department f neuroendocrinoloy, Ministry of Health of the Republic of Uzbekistan.Republic of Uzbekistan, 100125, Tashkent, Mirzo Ulugbek str. 56M.Yu. Shakirova, Yu.M. UrmanovaThe aim: To study dynamics of indicators of the questionnaire of QoL AGHD at assessment of quality of life a...

ea0056ep126 | Pituitary and Neuroendocrinology | ECE2018

Years of Misery: a final resolution ‘panhypopituiatirsm’

Bonner Caoimhe , Grant Bonnie , Hawkins Anna , Lee Yun-ni , Williams Augustine , Chawda Sanjiv , Tanday Raj , Casey Edel , Nikookam Khash

We report a case of a 76 year old gentleman referred to the endocrine department by his general practitioner (GP) with a few years history of severe lethargy, low mood, and dizziness on changing posture. He is known to have hypothyroidism, hypertension, hypercholesterolaemia, benign prostatic hypertrophy, and benign colonic polyps. His medications included amlodipine, finasteride, lansoprazole, atorvastatin and levothyroxine. Examination of all systems were unremarkable, in pa...

ea0056ep127 | Pituitary and Neuroendocrinology | ECE2018

Prolactinoma and granulomatous mastitis

Soussou Maryam , Mghari Ghizlane EL , Ansari Nawal EL

Granulomatous mastitis (GM) is an inflammatory lesion of the breast relatively rare with multiple etiologies suggested. Although most cases of GM show an association with breastfeeding and pregnancy, a minority of cases were related to hyperprolactinemia caused either by drugs dopamine antagonists or intracranial lesions, including pituitary adenoma. We report a case of a patient who had GM associated with microprolactinoma. Surgical treatment of the adenoma was indicated beca...

ea0056ep128 | Pituitary and Neuroendocrinology | ECE2018

Epidermoid cyst of the sella turcica: about a case

Bahia Habra , Ghizlane Elmghari , Nawal El Ansari

Introduction: Epidermoid cyst (EC) or cholesteatoma is a benign tumor, often of congenital origin. It accounts for 1% of intracranial tumors and is mainly located at the ponto-cerebellar angle and suprasellar, EC takes the aspect of a beaded tumor with nodular surface and white pearly color simulating candle wax. The treatment is surgical taking into account the substitution of endocrine pituitary deficits in this form of description.Patient and observat...

ea0056ep129 | Pituitary and Neuroendocrinology | ECE2018

Adult onset hypopituitarism – a surprising diagnosis in a postmenopausal women

Taujan Georgiana Cristina , Dragomir Adina Simona , Olaru Maria , Dumitru Alina Maria

Adult-onset hypopituitarism is a frequently delayed diagnosis because of the insidious debut and non-specific symptoms, frequently attributed to normal aging or many other pathologies - fatigue, malaise, cognitive impairment, decreased libido. Left untreated, it can have severe consequences with vital impact.Case-report: We present the case of a female patient, aged 69, who was initially addressed for evaluation of hypercalcemia. She had had four live bi...

ea0056ep131 | Pituitary and Neuroendocrinology | ECE2018

Gonadotropinoma without clinical function

Celer Ozgen , Celikoglu Erhan

Introduction: Pituitary adenomas are the most common cause of sellar masses. Several types of tumors may involve the sellar region, because of complex anatomy. They are classified according to size, function, immunohistochemical examination cell type of adenomas. Most of the pituitary adenomas without clinical function are gonadotropin-releasing adenomas on immunohistochemical examinations. They are usually seen as macroadenomas. They are often diagnosed with pituitary insuffi...

ea0056ep132 | Pituitary and Neuroendocrinology | ECE2018

Pitfalls in the management of inadequate TSH in the outpatient endocrine clinic: a case report

Marinkovic Snezana

A 34-years old woman was referred to the outpatient clinic due to elevated TSH level during last three years. She was aware on the decreased thyroid function due to autoimmune thyroiditis since she was 24-years old. At that time L-thyroxine was introduced to the patient in a daily dose od 75 μg. Since elevated TSH up to 6.3 mU/l was noticed, she experienced frequent temporal headaches, noticed enlargement of hands, lips and nose, and increased shoes size. H...

ea0056ep133 | Pituitary and Neuroendocrinology | ECE2018

Galactorrhoea, severe anxiety and an unexpected outcome

Bonner Caoimhe , Grant Bonnie , Pittathankal Anthony , Syed Imran , Casey Edel , Nikookam Khash

We report a case of a 43 year old lady who was referred by her general practitioner (GP) to the endocrine team with an 8 month history of extreme fatigue, difficulty losing weight, galactorrhoea and mild breast enlargement. She has two children aged 16 and 14, all well. Her background medical history included depression, asthma and hysterectomy for fibroids 3 years ago. Examination of all systems were unremarkable including visual fields to confrontation, fundoscopy and full n...

ea0056ep134 | Pituitary and Neuroendocrinology | ECE2018

A case of acromegaly and Cushing’s syndrome

Bensmaine Faiza , Laloie Marie , Barka Ines , Vidal-Trecan Tiphaine , Bouche Clara , Feron Florine , Riveline Jean-Pierre , Gautier Jean-Francois

We herein describe a 55-year-old woman who showed a dramatic improvement in glucose control following treatment for co-existing acromegaly and Cushing’s syndrome. The co-occurrence of acromegaly and Cushing’s syndrome in one individual is extremely rare. This patient was diagnosed as having diabetes mellitus 7 years ago. Afterwards, in spite of insulin therapy, her hyperglycemia could not be well controlled. Endocrinological and radiological examinations revealed sub...

ea0056ep135 | Pituitary and Neuroendocrinology | ECE2018

Clinical and diagnostic features of prolactinomas

Nasirova Khurshida , Mukhammedaminova Diyora , Mirzaeva Umida

Relevance: Prolactinoma is an adenoma of the pituitary gland with the production and secretion of prolactin (PRL) in varying degrees, almost always benign, but, nevertheless, often clinically significant and causing difficulties in treatment. Often prolactinomas are classified according to size as microadenomas (less than 10 mm in diameter) or macroadenomas (more than 10 mm in diameter). More than 90% of prolactinomas are small, intrasellar tumors that rarely increase in size....