Endocrine Abstracts

Background and Aim: Turner’s syndrome (TS) or 45 XO is a condition in which a female is partly or completely missing an X chromosome. TS affects 0.025–0.05% of females and can involve multiple organs through all stages of life, necessitating a multidisciplinary approach to care. We aim to evaluate our practice compared to the clinical practice guidelines, which recommends the following: annual BMI, blood pressure, HbA1c, lipid profile, liver function, thyroid functio...

Introduction: Premature ovarian failure (POF) is defined as amenorrhea lasting more than four months before the age of 40 with a high level of gonadotropins in at least two separate samples. The aim of this work was to describe the etiological profile of a series of Tunisian women followed for POF.Patients and methods: It is a descriptive study of 42 cases of POF collected in the endocrinology department of Sousse between 2000 and 2017.<p class="abst...

Introduction: The purpose of this study was to evaluate the relation between menopausal women and the thiol/disulphide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.Methods: Fourty five postmenopausal subject and 39 healthy participant were included in the study.Results: We found that in postmenopausal group, disulphide (P=0.04), disulphide/native thiol (P=0.004)...

Background and objectives: PCOS is the most common endocrine disorders among women between the ages of 17 and 44. It affects approximately 5% to 10% of this age group. It is one of the leading causes of poor fertility. PCOS patients usually develop thyroid disorders which have an adverse effect on fertility and other hormones. Hence this study was done to estimate levels of LH, FSH, and TSH hormones and to find a correlation between LH,FSH and TSH levels.<p class="abstext"...

Cuscuta japonica chois (CJC) has been used traditionally to treat sexual disorder and skin problem such as pimples, freckles and melasma in Korea. The present study aimed to investigate the alleviating effect of CJC extract on surgical injury-induced ischemia in the hind-limb of mice. In this study, Female C57BL/6 mice were ovariectomized and excised the vessels of hind-limb after ligated by surgical silk (6-0). The mice were administered with CJC (150 or 450 mg/kg per day) fo...

Objective: The purpose of this study was to investigate the contraceptive practice and sociodemographic determinants of employment of contraceptive methods among sexually active Roma and non-Roma women.Design and methods: This research included 133 Roma and 687 non-Roma women aged 18–26 from secondary schools Szeged. Women completed self-report questionnaires on sociodemographic characteristics, contraceptive practice and sexual activity between 201...

Isochromosome Mosaic Turner Syndrome (IMTS) is a variant of Turner Syndrome (TS) characterized by cytogenetic profile of 1 or more additional cell lineages aside from 45,X, and the presence of a structurally abnormal X chromosome consisting of either two short or two long arms. IMTS is rare, with only 8–9% prevalence among women with TS based on international studies, and 15% of all TS in the Philippines. A 20 year old female came in due to amenorrhea and alopecia. Physic...

Background: The polycystic ovary syndrome (PCOS) is often seen in reproductive age women. Although the ratio of insulin resistance is not knowm definitely in PCOS patients it is thought to be between 50 to 65%. Several studies have shown that low serum 25-Hydroxy Vitamin D (25(OH) D) levels are associated with high body mass index (BMI), insulin resistance, and waist/hip circumference, but it has not yet been clearly determined. In this study, we aimed to determine the correla...

Imipenem (IMP) is a carbapenem antibiotic mainly used to treat nosocomial infection diseases. We aimed to evaluate the oxidative stress of therapeutic doses of imipenem (IMP) on the ovary of ‘wistar’ rats. In this respect, female rats were divided into four groups: animals were intraperitoneally treated with physiological serum, 30, 50 and 80 mg/kg of IMP for one week. We found that therapeutic doses of this drug did not significantly affect the levels of ovarian mal...

Objectives: • PCOS is defined by the presence of hyperandrogenism (clinical and/or biochemical), ovarian dysfunction (oligo-anovulation and/or polycystic ovaries), and the exclusion of related disorders.• Women are exposed to increased risk for cardiovascular disease, hypertension, type 2 diabetes mellitus and other metabolic complications• Cardiovascular disease (CVD) is one of the most common cause of mortality wor...

A 69-year-old patient with a history of hysterectomy 18 years ago due to apparent uterine myomatosis, who presents with a clinical picture of 6 months of evolution of a solid suprapubic mass without any other associated symptomatology. Normal vaginal cytology 3 years ago; Menarche at 16 years of age and obstetric history: G1P2V2(Twin).Physical examination: Indurated mass in the suprapubic region, mobile, not painful External atrophic genitalia; Vaginal e...

Turner syndrome (TS) is a chromosomal abnormality, due to a total or partial loss of one of the X chromosomes and is mostly characterized clinically by short stature and primary ovarian insufficiency. Spontaneous pregnancies in TS are rare (5%) and of relatively high risk, due to cardiovascular complications. Therefore, close medical monitoring is required. We report a case of a 21-year old woman with TS that had a full term uncomplicated pregnancy after spontaneous conception...

Aim: The aim of the study was to evaluate the birth weight of children born to women with AITD compared to with those born to women without AITD.Material and methods: The study included 596 pregnant women and their children in 2007–2015. The patients were divided into two groups. The first (group A) consisted of 191 pregnant women with chronic autoimmune thyroiditis and their children, while the second (group B) consisted of 405 pregnant women witho...

This is a 38-year-old male, a regular user of a gym with the sole purpose of improving his physical performance and muscular strength and habitual consumer of hyperproteic dietary supplements. Among his PAs he denies toxic habits, and highlights the removal of the right testicle in childhood. Consultation for decreased desire and sexual potency, together with pain and turgor in the left breast; hair loss at the frontal level, in analytic carried out by the Primary Care Physici...

Introduction: The management of schizophrenia involves drugs which inhibit domapine receptors. The drugs control the disease. However, they increase prolactin secretion and induce amenorrhea. The drugs induce the development of metabolic syndrome and as a result of obesity they may cause benign intracranial hypertension.Aim: The aim was to describe the case of a patient who developed schizophrenia and after therapy with antipsychotics benign intracranial...

Introduction: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder, characterized by chronic anovulation and hyperandrogenism. Hirsutism, defined as excessive terminal hair that appears in a male pattern in a woman, is frequently present in patients with PCOS. We aimed to determine the clinical and biological characteristics of hirsute patients with PCOS.Methods: It was a retrospective study included 30 women diagnosed with PCOS according to the ...

Introduction: The therapeutic management of premature ovarian failure (POF) consists of a hormone replacement therapy that must be regular to avoid cardiovascular and bone complications as well as psychological management. The objective of this work was to study complications at 15 years of evolution of 42 tunisian women followed for POF.Patients and methods: It’s a retrospective study of 42 patients followed in the endocrinology department of Souss...

Introduction: Precocious puberty (PP) is the development of secondary sexual characteristics before the age of 8 years in girls and beforethe age of 9 years in boys. Central PP has an idiopathic origin in upto 95% of girls while in up to 50% of males. The diagnostic and the management of PP can beparticularly complex. Here we describe cases of two sisters having central PP with different presentation and evolution.Observations: First case: A 13-years-old...

The normal development of the female reproductive tract depends on the interaction between genetic, hormonal and environmental factors for the differentiation of the Müller and Wolff ducts, and the urogenital sinusCase report: 16-year-old female, single, school student presented to our endocrine department complaining of primary amenorrhea. No history of chronic diseases, excessive exercise,medications, anorexia, clinical hypothyroidism or hyperandr...