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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056ep155 | Thyroid | ECE2018

Thyroid disease in very elderly patients

Marti Juan , Jordana Lluis , Zurutuza Marisol

Objective: To know characteristics of patients older than 80 years with thyroid disease.Patients and methods: Prospective 6-month study in which we analyze characteristics of patients that have been treated and followed for thyroid disease in endocrinology consult.Results: Hundred and fifteen patients were analyzed of them, 23 men and 92 women, with 83.78±2.12 years-old. Comorbidities. Arterial hypertension 53%, previous neopl...

ea0056ep156 | Thyroid | ECE2018

Pituitary hyperplasia secondary to congenital primary hypothyroidism in adult patient

Khessairi Nadia , Oueslati Ibtissem , Chaker Fatma , Yazidi Meriem , Chihaoui Melika , Rejeb Ons , Slimane Hedia

Introduction: The reactive pituitary gland enlargement is a non-neoplastic growth of at least one pituitary lineage, which can often be essential or secondary to prolonged deficit of a gland target. It may be difficult to differentiate from functional pituitary adenomas. Herein we report a case of pituitary hyperplasia secondary to congenital primary hypothyroidism diagnosed at the age of 38 years.Observation: A 38-year-old female patient presented with ...

ea0056ep157 | Thyroid | ECE2018

Abstract withdrawn....

ea0056ep158 | Thyroid | ECE2018

What should be the cut-off level for antithyroperoxydase antibody? January 2018

Oprisan Bogdan , Ratcu Mihaela , Ilie Cosmina , Gharibafshar Payman , Peretianu Dan , Carsote Mara

Aim: The biological diagnostic of Hashimoto thyroiditis (HT) is based on higher than normal levels of antithyroperoxydase antibodies (ATPO). Our goal was to establish the cut-off limit of normality (the upper limit) for ATPO in our thyroid normal patients. This limit, and not that of the laboratory, should be used as diagnosis of Hashimoto thyroiditis.Material and method: 1. ATPO was investigated in patients with normal level of thyroid hormones (euthyro...

ea0056ep159 | Thyroid | ECE2018

Total thyroidectomy can be a radical method of treatment of Grave’s disease in alcohol addicted patient who has hepatitis B at the same time, because medical treatment can aggrivate liver disease and bring to recurrence of Grave’s disease

Hambardzumyan Meri

34 years old male patient was admitted to Endocrine department with palpitation (130–140 beats/minute), weight loss(15 kg during 3 months), anxiety, nervousness, hand tremor, generalized nocturnal pruritus. Laboratory examination showed: decreased level of thyroid stimulating hormone (TSH) <0.005 (n 0.3–4.0 iu/ml), markedly increased level of free thyroxin (FT4) - 100(n 12–22 pmol/l), free triiodthryonine FT3-6,5 (n-0,8-2,0 ng/ml),anti-R-TSH 15-(n- <1,75...

ea0056ep160 | Thyroid | ECE2018

The complications of diseases of thyroid gland at children and teenagers according to data for 5 years

Azimova Shakhnoza , Urmanova Yulduz , Rikhsieva Nazira , Khodgaeva Feruza , Min Dgi Kim , Tursunkulov Ortikali , Akhmadiev Edvard

The aim: To study the complications of diseases of thyroid gland at children and teenagers according to data for 5 years.Material and methods of investigation: Under supervision of the employees of the department of children’s endocrinology the Center of Endocrinology of PH of RUz during from 2012 on 2016 years was hospitalized 213 children and teenagers with various diseases of thyroid gland, from them of the boys was - 67 (31,4%), girls -146 (68,5...

ea0056ep161 | Thyroid | ECE2018

A TSH pituitary adenoma due to Hashimoto Thyroiditis and L-tiriiodotironin treatment experience: Case report

Eklioglu Beray Selver , Selver Muhammed Burak , Atabek Mehmet Emre

Aim: We report a child with reactive pituitary enlargement and microadenoma due to Hashimoto thyroiditis.We want to emphasize the importance of good endocrine evaluation in pediatric cases of pituitary adenomasCase report: A 7 year 7 month old boy presented with mild symptoms of hypothyroidism. There was no feature in his past medical story.He had normal cognitive and neurological development. At physical examination his weight was 24 kg (0.06 SDS) and h...

ea0056ep162 | Thyroid | ECE2018

Expectant management in patients with multinodular goiter: expected development options

Aleksandrov Yuri , Dyakiv Artem , Semikov Vasilyi

Today dynamic observation are given preference in most cases multinodular goiter. Small nodes without disruption of thyroid function do not affect the quality of life of patients. Wait-and-see tactic with multinodular goiter has previously been submitted due to the lack of adequate replacement therapy. Wait-and-see tactic previously criticized because of its passivity and predictable negative effect on growth nodes. The result of passive observation is the occurrence of goiter...

ea0056ep163 | Thyroid | ECE2018

The effects of vitamin D supplementation on insulin resistance in patients with hypothyroidism

Pankiv Ivan

Background: Over the past decade, numerous non-skeletal diseases have been reported to be associated with vitamin D deficiency including autoimmune thyroid pathology.Aim: The aim of the study is to evaluate the effects of vitamin D supplementation on insulin resistance in hypothyroidism.Materials and methods: Forty-seven participants, 32–74 years old, including 39 women (82.9%) and 8 men (17.1%) took part in the study. Serum T...

ea0056ep164 | Thyroid | ECE2018

Clinical and morphological characteristics of the first time nodular goiter

Nadyrov Eldar , Savasteeva Irina , Makhlina Elena , Kolyada Inna , Evdochkova Tamara , Moskvicheva Tamara

We analyzed the results of a survey of 51 patients aged 18 to 25 years who were not exposed to 131I. Patients included in the study had a the first time nodular goiter. The median age of the patient at the time of the diagnosis of nodular goiter was 22.00 (20.32; 23.21) years. Male/female ratio was 1/16. In 23.5% of patients the site was formed against the background of autoimmune thyroiditis, in 76.5% the true nodal formations were...

ea0056ep165 | Thyroid | ECE2018

Thyrotoxic vomiting: an unusual presentation

Omer Tahir , Shrivastava Manu , Seetho Ian

Introduction: Thyrotoxicosis classically presents with tremor, goitre, sweating and diarrhoea. It is increasingly appreciated, however, that presentations can be complex and non-specific. Gastrointestinal symptoms in thyrotoxicosis are thought to derive from increased motility. Thyroid overactivity may be a cause for unexplained repeated vomiting and abdominal pain.Case: A case of 41-year-old man presented with a three-year history of intractable vomitin...

ea0056ep166 | Thyroid | ECE2018

Thyrotoxic periodic paralysis: a rare complication of hyperthyroidism for 21-year-old male.

Petraviciute Modesta , Naskauskiene Gintare , Dunauskas Vigantas , Visockiene Zydrune

Introduction: Thyrotoxic periodic paralysis (TPP) is very rare (prevalence in non-Asian populations 0.1–0.2%, more frequent in men) and potentially life-threatening complication of hyperthyroidism. TPP develops when thyroid hormones cause sodium-potassium-adenosine triphosphatase (Na/K-ATPase) pump overactivity, leading to rapid potassium shift into the cells resulting in hypokalaemia. This causes transient episode of muscular weakness usually involving lower limbs and hy...

ea0056ep167 | Thyroid | ECE2018

Graves disease, pericarditis and thymus hyperplasia: the improbable triad!

Ivo Catarina , Verissimo David , Pires Vitoria , Serra Filipa , Passos Dolores , Lopes Luis , de Castro Joao Jacome , Marcelino Mafalda

Introduction: Ophthalmopathy and dermatopathy are the most frequent manifestations of Graves Disease (GD). It is also known the relation between GD and other autoimmune diseases like myasthenia gravis. Thymus hyperplasia in GD is already documented on literature but it’s mechanism is not well understood. There are two possible explanations, one related to thyrotrophin receptors stimulation present on thymus, and other related to tissue stimulation due to generalized hyper...

ea0056ep168 | Thyroid | ECE2018

Familial dysalbuminaemic hyperthyroxinaemia, a thyroid conundrum

Subramaniam Yuvanaa , Mlawa Gideon

Background: Familial dysalbuminaemic hyperthyroxinaemia (FDH) is an interesting autosomal dominant condition that is associated with euthyroid hyperthyroxinaemia, whereby patients remain euthyroid but laboratory value will show high free thyroxine (fT4) level. It is caused by mutations in ALB (albumin) gene that increase affinity of albumin for thyroxine (T4). The usual thyroid assay will show a spuriously high level of thyroxine. This interferen...

ea0056ep169 | Thyroid | ECE2018

Two cases of Graves dermopathy: A rare and pathognomonic symptom

Bilginer Muhammet Cuneyt , Polat Burcak , Ogmen Berna , Ersoy Reyhan , Cakir Bekir

Introduction: Pretibial myxedema is a rare manifestation of Graves’ disease caused by local autoimmune attack of the connective tissue probably mediated by anti TSH receptor autoantibodies (TRab). Its prevalence changes between 0.4 and 5% in Graves ‘patients and usually is accompanied by opthalmopathy. The diagnosis requires physical examination and clinical suspicion and in doubtful cases biopsy may be performed.Case 1: Sixty four years old fe...

ea0056ep170 | Thyroid | ECE2018

BsmI, TaqI, ApaI and FokI VDR polymorphism in women wit and without goiter

Kolodziejczak Roman , Luczynska-Kolodziejczak Alicja , Syrenicz Anhelli , Koziolek Monika

Objective: Vitamin D deficiency is common in polish population and seem to play role in pathogenesis of some diseases. We looked for correlation between polymorphisms BsmI, TaqI, ApaI and FokI of vitamin D receptor and vitamin D influence on goiter development.Methods: One hundred and fifty two women-96 with and 56 without nontoxic goiter were examined in 2014. In US examination we calculated the volume of the thyroid gland and volume of nodules. Blood s...

ea0056ep171 | Thyroid | ECE2018

An unusual presentation of Graves’ Ophtalmopathy: About 3 cases

Boulbaroud Zineb , El Aziz Siham , Chadli Asma

Introduction: Dysthyroid ophthalmopathy corresponds to eye damage encountered in various thyroid diseases. It is seen mainly in Graves’ disease, and may develop any time in the course of the disease evolution. Clinical presentations of Graves’ ophtalmopathy (GO) are extremely heterogeneous. GO may be sight threatening in 3–5% of cases, and then represent an emergency requiring immediate treatment. We report three cases illustrating a particular&#19...

ea0056ep172 | Thyroid | ECE2018

BRCA1 mutations and polyporphisms in women with and without goiter

Kolodziejczak Roman , Luczynska-Kolodziejczak Alicja , Syrenicz Anhelli , Koziolek Monika

Objective: There are many suggestions of predispositions to goiter in women with benign and malignant masthopaty, we looked for BRCA1 mutations in women wit and without goiterMethods: One hundred and fifty two women-96 with and 56 without nontoxic goiter were examined in 2014. In US examination we calculated the volume of the thyroid gland and volume of nodules. Blood samples for BRCA1 were taken, ex05 - p.Cys61Gly; ex 11 polymorphisms K1183R, mutations:...

ea0056ep173 | Thyroid | ECE2018

Simultaneous occurrence of papillary and medullar thyroid carcinoma report of a case

Ilham Bouizammarne , Ghizlane El Mghari , Nawal El Ansari

Introduction: Mixed thyroid carcinoma is an entity that corresponds to tumors with a double component: one of the vesicular type (Tg +) and the other of the medullary type (CT +). We report the occurrence of papillary and medullary thyroid carcinoma in a 44-year-old patient. This coexistence is considered rare.Case: A 44-year-old patient underwent a thyroidectomy due to a goiter, histopathological examination identified multifocal papillary carcinoma, mu...

ea0056ep174 | Thyroid | ECE2018

Graves’ ophthalmopathy presenting with hypothyroidism

Athanassiou Panagiotis , Pantazi Eleni , Athanassiou Lambros , Xanthakou Eleni , Spyropoulos Panagiotis , Kostoglou-Athanassiou Ifigenia

Introduction: Graves’ disease is a multi-system autoimmune disease characterized by hyperthyroidism, ophthalmopathy and pretibial myxedema. The disease presents with hyperthyroidism or more rarely with ophthalmopathy. It runs a various course and many times during its natural course permanent hypothyroidism may ensue.Aim: The aim was to describe the case of a patient with Graves’ disease presenting with ophthalmopathy and subclinical hypothyroi...

ea0056ep175 | Thyroid | ECE2018

Cretinism and language delay are rare manifestations of central hypothyroidism: 2 cases report

Beldi Vinicius , Marson Tomas , Araujo Aiana , Siena Thais , de Paula Mariana , Atique Patricia , Custodio Rodrigo , Maciel Lea , Ferraz Ivan , Del Ciampo Luiz , Martinelli Carlos

Cretinism and neurological impairment are related to primary hypothyroidism (PHT) while children with central hypothyroidism (CHT) are usually diagnosed during the investigation process for short stature.Objective: To describe two children with unusual presentation of CHT.Case 1: Baby girl, born after 38 weeks of gestation, weighing 3000 g, and measuring 49.5 cm long was admitted when 3 months old. The parents reported stunted neur...

ea0056ep176 | Thyroid | ECE2018

Strumectomy in nodular goiter - does it make sense? Reflections after 22 years of observation of one patient

Marczewski Krzysztof , Wegrzyn-Bek Marta , Boniek-Poprawa Dorota , Maciejewski Marek

Introduction: Although the thyroidectomy is one of the most frequently performed operations in endocrine surgery, indications for this procedure as well as recommendations for further observation are still controversial. Therefore we would like to present what is happen with our patient during 22 years after thyroid surgery.Case report: In 1995, at the 46-year-old woman at that time, a subtotal strumectomy was performed due to the nodular goiter. Postope...

ea0056ep177 | Thyroid | ECE2018

Simultaneous medullary and papillary thyroid cancer in Graves-Basedow disease. Two case reports

Dumitriu Roxana , Petrova Eugenia , Buruiana Andra , Ghemigian Mircea , Ghemigian Adina

Introduction: The occurence of simultaneous medullary and papillary thyroid cancer is very rare. There were only 17 case reports in the literature, and fewer with Graves-Basedow disease associated. A retrospective study conducted at the National Institute of Endocrinology ‘C. I. Parhon’ showed that 7,6%of the patients who underwent total thyroidectomy for Graves-Basedow disease had thyroid cancer. Recent studies show that specific cellular pathways are determined by ...

ea0056ep178 | Thyroid | ECE2018

A rare case of hurthle cell adenoma and parathyroid adenoma

Sarac Fulden , Savas Sumru , Tutuncuoglu Pelin

Introduction: Hurthle cell of adenoma (HCA)of thyroid gland is rare neoplasms of the thyroid. They have been found in association with various benign thyroid conditions like Hashimoto’s thyroiditis, hyperthyroidism, nodular goiter, and thyroid neoplasms; where they often represent oncocytic metaplasia. Oncocytic cells are also present in normal parathyroid tissue. Oncocytic parathyroid adenomas, predominantly (more than 70%) or exclusively composed of oncocytic cells are ...

ea0056ep179 | Thyroid | ECE2018

Prognostic factors affecting neck lymphnode recurrence and distant metastasis in papillary thyroid cancer: results of a study in 40 patients

Papadakis Georgios , Triantafillou Eleni , Kanouta Fotini , Drosou Aspasia , Kalaitzidou Styliani , Sapera Aggeliki , Tampouratzi Dimitra , Kotis Michalis , Kyrimis Taxiarchis , Aravantinou Aggeliki , Karavasili Chrysa , Drakopoulou Anna , Veniou Eirini , Kaltzidou Victoria , Tertipi Athanasia

Objectives: Overall, papillary and follicular carcinoma is associated with a 30-year cancer-related death rate of 6 and 15%, respectively. Poorer outcomes have been associated with older age, male gender, tumor size, grade and extrathyroidal extension. We investigated the clinical and laboratory characteristics of 40 patients who presented recurrence of thyroid disease.Patients data: • 40 Patients (21 Females and 19 males) with papillary thyroid can...

ea0056ep180 | Thyroid | ECE2018

The association of breast cancer and thyroid cancer: what relationship? (Preliminary results)

Iftahy Fatima Zahra , El Aziz Siham , Chadli Asma

Background: Several studies have demonstrated the relationship between breast cancer and thyroid cancer by the presence of common genetic determinants as well as hormonal factors. The aim of the study was to define the prevalence of breast cancer among patients followed for thyroid carcinoma and to determine the factors that favor this association.Materials and methods: A Cross-sectional study was conducted in Endocrinology and Diabetology department of ...

ea0056ep181 | Thyroid | ECE2018

Association thyroid carcinoma and lung adenocarcinoma

Kibhat Lygie , El aziz Siham , Mjebbar Asmaa , Chadli Asma

Introduction: Pulmonary adenocarcinoma is an epithelial tumor with differentiation glandular whose frequency increases sharply. The association with cancer thyroid is rare. In this context, we report a medical observation.Observation: A 58-year-old patient with no history of smoking was admitted to one of our departments. Thyroidectomy 4 years ago, the pathological study a poorly differentiated carcinoma of 4.5 cm, class PT2 TNM. Our patient had benefite...

ea0056ep182 | Thyroid | ECE2018

The concept of idiopathic myxedema: The relationships between hypothyroidism and ATPO evolutive level

Oprisan Bogdan , Peretianu Dan , Ratcu Mihaela , Gharibafshar Payman , Staicu Dana Cristina , Carsote Mara

Background: Hashimoto thyroiditis (HT) is defined as thyroid chronic inflammation due to high level antithyroperoxydase antoantibodies (ATPO) and/or antithyroglobuline autoantibodies (ATG) and their destructive process on thyroid cell. The diagnostic uses specific and very characteristic ultrasound features. What diagnosis has to have those patients with ultrasound features of HT, who are hypothyroid, but with normal levels of ATPOs and normal levels of ATGs ?<p c...

ea0056ep183 | Thyroid | ECE2018

The frequency, specification of diseases of thyroid gland at children and teenagers according to data for 5 years and the kinds of surgical treatment”

Urmanova Yulduz , Azimova Shakhnoza , Rokhsieva Nazira , Khodjaeva Firuza , Nasirova Khurshida , Dji Kim Min , Tursunkulov Ortikali , Akhmadiev Edvard

The aim: To study the frequency, specification of diseases of thyroid gland at children and teenagers according to data for 5 years and the kinds of surgical treatmentMaterial and methods of investigation: Under supervision of the employees of the department of children’s endocrinology the Center of Endocrinology of PH of RUz during from 2012 to 2016 years was hospitalized 213 children and teenagers with various diseases of thyroid gland, from them ...

ea0056ep184 | Thyroid | ECE2018

Role of thyroid dysfunction in patients with menstrual disorders

Nasirova Khurshida , Amilova Aziza

Menstrual disorders pose a huge burden on gynecology OPD, accounting for approximately 20% of attendance Thyroid hormones play an important role in reproductive function by direct effects on ovaries and indirectly influencing on sex hormone-binding globulin. Thyroid impairment can cause menstrual irregularities and infertility. In India, thyroid disorders are most common endocrine diseases. Thyroid disorders manifestation increases with age, and approximately 26% of premenopau...

ea0056ep185 | Thyroid | ECE2018

It is a link between gallstone disease and pathology of thyroid gland

Wegrzyn-Bak Marta , Marczewski Krzysztof , Maciejewski Marek

Introduction: Gallstone disease is one of most common in the Europe with prevalence till 15%. The basic mechanism of stone formation is precipitation of cholesterol crystals in the supersaturated bile. The relationship between thyroid function and the content of cholesterol has been known for quite a long time, as well as the work confirming the relationship between hypothyroidism and cholelithiasis. Recently, in mice it has been shown that both hypothyroidism and hyperthyroid...

ea0056ep186 | Thyroid | ECE2018

Graves’ disease in a patient with myasthenia gravis: a case report

Sakka Imen , Oueslati Ibtissem , Chihaoui Melika , Yazidi Meriem , Chaker Fatma , Rejeb Ons , Slimane Hedia

Introduction: Myasthenia gravis is an autoimmune neuromuscular disease characterized by the presence of anti-acetylcholine receptor antibodies. It can be isolated or associated with other auto-immune conditions. Graves’ disease is an autoimmune disorder typically characterized by the presence of circulating autoantibodies that tie to and stimulate the thyroid hormone receptor. Coexisting myasthenia gravis and Graves’ disease is a rare but well recognized condition. T...

ea0056ep187 | Thyroid | ECE2018

Case report and literature review. surgical management of hyperthyroidism in pregnancy

Lomba Alin Abreu , Santrich Melanie , Bastidas Claudia , Perdomo Gustavo , cifuentes rodrigo , Martinez Diana Milena

Hyperthyroidism during pregnancy is determined by decreased thyroid stimulating hormone (TSH), and high levels of thyroid hormones: thyroxine (T4), triiodothyronine (T3), being a complication in 1–2 women per 1,000 pregnancies, and occurs first as Graves’ disease in 0.1–1% of pregnancies. There are specific reference ranges of THS and free T4 for each population and each trimester. For the medical management in the first trimeste...

ea0056ep188 | Thyroid | ECE2018

Comparison of results of cytological and hystological research of thyroid gland nodes

Issaeva Saodat , Khalimova Zamira , Ismailov Said , Yuldashev Akram , Yuldasheva Feruza , Ubaydullaeva Nilufar , Allayarova Gulnara , Safarova Mijgona , Gumarova Aliya , Khodjaeva Saida

Purpose: To assess the sensitivity and specificity of the cytomorphological method in the diagnosis of the nosological variant of nodal goiter.Materials and methods: A comparison of the results of cytological and histological studies of thyroid nodules in 36 patients (15 women and 11 men, average age 54.2±9 years), operated for nodular goiter. Cytological findings were divided into 4 categories: ‘non-informative material’, ‘benign les...

ea0056ep189 | Thyroid | ECE2018

Incidence of thyroid cancer among patients with thyroid nodules

Gilmartin Aoife , Ryan Mary

Introduction: Thyroid nodules are observed in 8% of the entire population and have a 5–15% prevalence of malignancy. Thyroid cancer is the most common endocrine neoplasia. Advancements in diagnostic tools such as fine needle aspiration (FNA) are linked to an increasing incidence of thyroid cancer worldwide. The objective of this audit was to evaluate thyroid nodules and to determine the incidence of malignant and benign tumours.Methods: This retrosp...

ea0056ep190 | Thyroid | ECE2018

Insights from large-scale mHealth data: the impact of Levothyroxine dosage on intensities of symptoms experienced by Hashimoto’s patients

Tabor Vedrana Hogqvist , Tabor Mikael Hogqvist , Almquist Pelle

Hashimoto’s thyroiditis is the most common autoimmune condition, with increasing number of people being diagnosed and experiencing varying ranges of symptomes and intensities. This makes the diagnosis as well as treatment challenging. The benefit of preventive health management strategies has been successfully working for diabetes type 2, where condition is managed through implementation of healthy lifestyle and patient-doctor shared decision making. Health care today is ...

ea0056ep191 | Thyroid | ECE2018

Autoimmune thyroid disease (Hashimoto thyroiditis) disscussions as possible predicting of thyroid papillary microcarcinoma (MPTC)

Gogiashvili Liana , Gvianishvili Tamuna , Tsagareli Zurab

It’s have been reported, that an evidence a mixture of immune cells frequently found inside, or surrounding primary thyroid microcarcinoma. In this point of view, we support the concept, that the immune system, such autoimmune thyroid disease, may interfere or predict in thyroid carcinoma or microcarcinoma development and progression. Arising in nonneoplastic tissues, local immune response under autoimmune chronic thyroiditis would be associated with Hashimoto parenchyme ...