Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 56 | ECE2018 | Next issue

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

Card image cap
ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Oral Communications

Diving deep into adrenal cortex diseases

ea0056oc5.1 | Diving deep into adrenal cortex diseases | ECE2018

Is adrenal computed tomography accurate for the diagnosis of unilateral primary aldosteronism? A retrospective international cohort study

Williams Tracy Ann , Reincke Martin

Background: Unilateral primary aldosteronism is the most common surgically correctable form of endocrine hypertension, usually diagnosed by adrenal vein sampling (AVS) or computed tomography (CT). We compared the outcomes of patients diagnosed by CT and AVS and determined if CT can reliably diagnose unilateral primary aldosteronism in young patients with an evident phenotype.Methods: Patient data were obtained from 18 internationally distributed centres ...

ea0056oc5.2 | Diving deep into adrenal cortex diseases | ECE2018

Steroid profiling by liquid chromatography tandem mass spectrometry in a large cohort of patients with adrenal incidentalomas

Di Dalmazi Guido , Fanelli Flaminia , Zavatta Guido , Rinaldi Eleonora , Casadio Elena , Bitti Silvia Ricci , Mezzullo Marco , Vicennati Valentina , Pagotto Uberto

Background: Steroid profiling by mass spectrometry (MS) provided novel insights into the pathogenesis of adrenocortical tumors and hypercortisolism. The aims of the study were (I) to analyze the steroid profiling by liquid chromatography-tandem MS (LC-MS/MS) in a large cohort of patients with adrenal incidentalomas and (II) to investigate the relationship between steroid profile and clinical outcomes.Methods: We included 307 patients with mono- and bilat...

ea0056oc5.3 | Diving deep into adrenal cortex diseases | ECE2018

PRKACA L206R mutation in adrenal Cushing’s syndrome makes PKA RIIβ susceptible for caspase-mediated cleavage

Weigand Isabel , Ronchi Cristina L. , Hofner Kerstin , Vanselow Jens T. , Herterich Sabine , Bathon Kerstin , Schlosser Andreas , Fassnacht Martin , Calebiro Davide

Protein Kinase A (PKA) consists of two catalytic and two regulatory subunits with several isoforms (Cα, β, γ and RIα, IIα, Iβ, IIβ, respectively). Type II regulatory subunits are phosphorylated by PKA in their inhibitory sites, while type I are not. Somatic activating mutations in the gene encoding the catalytic subunit α (Cα) of PKA (PRKACA) have been found in 30–40% of cortisol-producing adrenocortical adenomas (CPA). We rece...

ea0056oc5.4 | Diving deep into adrenal cortex diseases | ECE2018

Assessment of Tissue Sodium Content by 23Na-MRI in Patients with Adrenal Insufficiency – a Pilot Study

Weng Andreas , Burger-Stritt Stephanie , Chifu Irina , Christa Martin , Petritsch Bernhard , Bley Thorsten , Kostler Herbert , Hahner Stefanie

Introduction: Patients with chronic primary adrenal insufficiency (PAI) depend on lifelong gluco- (GC) and mineralocorticoid (MC) replacement therapy. Reduced subjective well-being is however often described by these patients in absence of clinical or laboratory abnormalities and is thus a strong indicator of the gap between the concept of adequate hormone substitution and patients’ requirements. The aim of this study was to investigate the potential role of 23...

ea0056oc5.5 | Diving deep into adrenal cortex diseases | ECE2018

Cullin 3 is a partner of Armadillo Repeat Containing 5 (ARMC5), the product of the gene responsible for Primary Bilateral Macronodular Adrenal Hyperplasia

Cavalcante Isadora , Clauser Eric , Vaczlavik Anna , Drougat Ludivine , Lotfi Claudimara , Fragoso Maria , Rizk-Rabin Marthe , Bertherat Jerome , Ragazzon Bruno

Background: ARMC5 (armadillo repeat containing 5) has been identified as the gene responsible for PBMAH (Primary Bilateral Macronodular Adrenal Hyperplasia). ARMC5 inactivating mutations are reported in 20 to 25% of PBMAH patients. ARMC5, is considered as a tumor suppressor gene controlling apoptosis and regulating steroidogenesis. The mechanisms of action of ARMC5 are unknown. The structure of the ARMC5 protein contains ARM repeats and a BT...