Endocrine Abstracts

Development of type-2 diabetes (T2D) is critically affected by the loss of phenotypic flexibility. There is emerging evidence suggesting that, under adverse metabolic conditions, alternative mRNA splicing is markedly dysregulated at different levels. For this reason, we hypothesized that such dysregulation could contribute to loss of phenotypic flexibility. Consequently, we aimed to explore whether changes in the splicing machinery in peripheral blood mononuclear cells (PBMCs)...

Background: Earlier identification of diabetes patients at high risk of developing cardiovascular complication will help develop new therapeutic targets for the prevention of secondary diseases and death.Objectives: We aim to test the predictive value of toe brachial index (TBI) as a risk marker of major adverse cardiovascular events (MACE) in patients with type 2 diabetes.Methods: TBI was measured in 741 patients with type 2 diabe...

Introduction: Experimental studies suggest that a circulating protein called TRAIL (TNF-related apoptosis-inducing ligand) has the potential to treat type 2 diabetes mellitus (T2DM). We have recently demonstrated that TRAIL delivery ameliorates T2DM in the high-fat diet-fed mouse. This study aimed at evaluating whether TRAIL had the potential to treat not only T2DM but also diabetic nephropathy.Methods/design: Based on this background, 15 male db/H mice ...

Introduction: Diabetes is a major risk factor for chronic kidney disease (CKD). Previous studies have shown contradictory results regarding the effect of prediabetes in the development of CKD.Methods: We performed a secondary analysis of the SPRINT trial (Systolic Blood Pressure Intervention Trial) involving 9361 patients without diabetes and with an increased cardiovascular risk (clinical or subclinical cardiovascular disease, estimated glomerular filtr...

Background and aims: There are growing evidence supporting the deleterious effect of type 2 diabetes (T2D) on respiratory function and sleep breathing disorders. However, there is no information about the characteristics of lung function in the prediabetes stage.Methods: We assessed pulmonary function in 3,455 non-diabetic subjects, aged between 45 and 70 years, without vascular disease nor chronic pulmonary obstructive disease from the cross-sectional s...