Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p404 | Diabetes complications | ECE2018

Mortality related to diabetes in orthopedic surgery patients

Vega Maria Molina , Mora Pilar Losada , Castro Alfonso M Garrido , Linares Juan Luis Carrillo

Introduction: Episodes of poorly controlled diabetes (DM) are one of the most frequent medical complications during hospitalization in the elderly population.Goals: To analyze the mortality rate (M) in patients with DM who undergo some medical decompensation during an admission to Orthopedic Surgery and Traumatology (OST).Material and methods: Descriptive analysis of patients admitted to OST who suffered some type of medical decomp...

ea0056p405 | Diabetes complications | ECE2018

Mortality related to diabetes in vascular surgery patients

Vega Maria Molina , Mora Pilar Losada , Garrido Castro Alfonso M , Linares Juan Luis Carrillo

Introduction: Episodes of poorly controlled diabetes (DM) are one of the most frequent medical complications during hospitalization in the elderly population.Goals: To analyze the mortality rate (M) in patients with DM who undergo some medical decompensation during admission to Vascular Surgery and Angiology (VS).Material and methods: Descriptive analysis of patients admitted to VS who suffered some type of medical decompensation t...

ea0056p406 | Diabetes complications | ECE2018

Diabetes and other frequent clinical problems in patients admitted in orthopaedic surgery

Vega Maria Molina , Mora Pilar Losada , Castro Alfonso Garrido , Linares Juan L Carrillo

Objectives: To analyze the most frequent consultations on patients admitted to Orthopedic Surgery and Traumatology (OST) unit asked to medical physicians.Material and methods: Descriptive analysis of consultations on patients admitted to OST who suffered any medical decompensation that needed to be notified.Results: From June 2008 to November 2014, 1486 consultations were sent from OST to a medical team (Internal Medicine+Cardiolog...

ea0056p407 | Diabetes complications | ECE2018

Abstract withdrawn....

ea0056p408 | Diabetes complications | ECE2018

Oral health care behaviors among Tunisian patients with diabetes mellitus.

Imen Sebai , Aida Chelly , Aroua Temessek , Hajer Tertek , Faika Ben Mami

Aim: The aim of our study was to describe oral health care behaviors among diabetic patients in Tunisia.Method: This was a cross-sectional study involving diabetic patients hospitalised in the C department of the national institute of nutrition of Tunis between August and October 2016. A questionnaire contained a combination of open and close ended questions was specifically developed for this study. Patients were asked to answer questions related to the...

ea0056p409 | Diabetes complications | ECE2018

Clinical evaluation of erectile dysfunction in diabetic patients by IIEF5 Score

Ach Taieb , Hasni Yosra , Abdelkarim Asma Ben , Maaroufi Amel , Kacem Maha , Chaieb Molka , Ach Koussay

Introduction: The management of diabetes goes through the education but also the management of acute and chronic complications. Among the complications, erectile dysfunction are too often forgotten as they actually affect the quality of life. The repercussions of this complication incite the clinician to look for it among the other complications of diabetes. The aim of our study is to evaluate the prevalence of erectile dysfunction in a diabetic population and to evaluate its ...

ea0056p410 | Diabetes complications | ECE2018

Variability of glycemia and cognitive function in patients with type 1 diabetes mellitus

Matveeva Mariia , Samoilova Julia , Oleynik Oxana , Rotkank Mariya

Objective: To determine the effect of glycemic variability on cognitive function in patients with type 1 diabetes mellitus.Materials: Thirty patients with type 1 diabetes mellitus were examined at the age of 29.7 (27.45–30.4) years, the duration of the disease was 19 (15.1–20.3) years. Patients were divided into 2 groups: 1st group (n=15) – patients with cognitive impairment, 2nd group (n=15) – without.<p class="...

ea0056p411 | Diabetes complications | ECE2018

Septicemia in diabetics in Tunisia: Study of 43 cases

Elleuch Mouna , Abdallah Rihab Ben , Kolsi Boulbaba , Lahiani Dorra , Kacem Faten Haj , Rekik Nabila , Jemaa Mounir Ben , Abid Mohamed

Diabetes is a factor favoring infections. Among which, the sepsis that becomes formidable and serious on this ground. The purpose of our work is to study the clinical, therapeutic and evolutionary features of sepsis in diabetics. A retrospective study of 43 cases of septicemia in diabetic patients collected at the service of Sfax Infectious Diseases. There were 22 men and 21 women, mean age 59 (20–78) years. Community origin was present in 88.4% of cases and nosocomial in...

ea0056p412 | Diabetes complications | ECE2018

An association of non-alcoholic fatty liver disease and autonomic neuropathy parameters in patients with type 2 diabetes

Kim Yu Ji , Lee Kyung Ae , Jin Heung Yong , Park Tae Sun

Background: Non-alcoholic fatty liver disease (NAFLD) is metabolic disorder of the liver that is associated with type 2 diabetes.The relationship between NAFLD and diabetic neuropathy was still poorly understood. This study aimed to investigate whether the NAFLD is associated with the autonomic neuropathy parameters in patients with type 2 diabetes.Methods: A total of 174 patients with type 2 diabetes were included in this study. Patients were divided in...

ea0056p413 | Diabetes complications | ECE2018

Characteristics of cardiovascular autonomic neuropathy depending on the type of diabetes and importanace of cardiovascular tests in diagnostics

Popovic-Pejicic Snjezana , Pejicic Nina

Purpose: The goal of the study was to determine: existence and degree of diabetic cardiovascular autonomic neuropathy (DCAN) depending on the type of diabetes; influence on systolic and diastolic function of myocardium and correlation with coronary disease and cardiovascular risk factors; possibility of early detection and diagnostic value of cardiovascular tests (CVT).Methods: The study involved 90 participants: 30 patients with type 1 diabetes (T1DM), ...

ea0056p414 | Diabetes complications | ECE2018

Importance of HBA1C level and BMI in patients with chronic kidney disease

Popovic-Pejicic Snjezana , Figurek Andreja

Purpose: Diabetic nephropathy is one of the leading causes of chronic kidney disease (CKD). Poor regulated glycemic control can result in progression of CKD. As diabetes mellitus (DM) and obesity can participate in development of atherosclerosis, the aim of this study was to assess the association of HbA1c and BMI in patients with CKD with intima-media thickness (IMT) as the early marker of atherosclerosis.Methods: This cross-sectional study included 88 ...

ea0056p415 | Diabetes complications | ECE2018

The results of questionnaire by comprehensive symptom profile diabetes mellitus hypoglycemia nodule in type 2 diabetes patients

Ismailov Said , Vodovskaya Alexandra

The aim: To evaluate the results of Questionnaire by Comprehensive Symptom Profile Diabetes Mellitus hypoglycemia (CSP-DM-HypoGl) nodule in type 2 diabetes patientsMaterial and methods: Under our supervision in the departments of the Center of Endocrinology of PH Ministry of RUz in the period from September 2016 for December, to 2017, 20 patients were observed with DM 2, men – 9, women-11; 54.5±1.5 m/61,6±1.8 w years old. The remoteness of...

ea0056p416 | Diabetes complications | ECE2018

Comparitive angiographic profile in diabetic and non-diabetic patient (retrospective study)

Dyrmishi Blertina , Olldashi Taulant , Lumi Ema , Puca Entela , YLLI Dorina

Background: Diabetes is one of the risk factor for coronary disease. Patient with diabetes have a increased prevalence and incidence of coronary vessels disease compare with the people without diabetes in the general population.Aim and objectives: To compare the study of angiographic coronary results in the patient with and without diabetes.Materials and methods: 172 pacients; 66 with diabetes and 106 without diabetes was admitted ...

ea0056p417 | Diabetes complications | ECE2018

Thiol-disulfide homeostasis, total antioxidant capacity and advanced oxidant protein products in patients with diabetic peripheral neuropathy

Eroglu Derya Ustun , Kiyici Sinem , Ustundag Yasemin , Sigirli Deniz , Pekel Nilufer Buyukkoyuncu , Emlek Gamze , Kisakol Gurcan

Aim: In our study, we aimed to evaluate the relationship between oxidative stress markers such as total antioxidant capacity (TAC), advanced oxidant protein products (AOPP) and thiol-disulfide homeostasis parameters and diabetic peripheral neuropathy (PNP), an important microvascular complication of diabetes mellitus (DM).Material and methods: 80 (male/female=34/46) patients with type 2 DM and 19 healthy controls were included in the stu...

ea0056p418 | Diabetes complications | ECE2018

Association of dislipidemia and glycemic control in patients with type 1 diabetes mellitus

Makhlina Elena , Mokhort Tatiana , Navmenova Yana , Kaplieva Marina , Savosteeva Irina

Objective: Assessment of the association of dyslipidemia and glycemic control in patients with type 1 diabetes mellitusMaterials and methods: 200 patients with DM 1 were examined (mean age 29.14±7.33 years, duration of DM 1 10.00±7.33 years). The study of daily glucose dynamics was carried out by the continuous glucose monitoring system (CGMS) of Medtronic MINIMED, USA. HbA1c and lipid metabolism parameters were determined by the biochemical an...

ea0056p419 | Diabetes complications | ECE2018

Urinary neutrophil gelatinase-associated lipocalin (NGAL) as a marker of diabetic nephropathy in type 1 diabetic patients

Sisman Pinar , Gul Ozen Oz , Dirican Melahat , Bal Ahmet Selim , Cander Soner , Erturk Erdinc

Aims: Glomerular and tubulointerstitial damage plays a role in renal function failure in diabetic patients. While both serum and urine levels of neutrophil gelatinase-associated lipocalin (NGAL) show significantly increased levels in acute renal pathologies, the NGAL increase in active phase indicates a reversible condition in chronic cases. In this study, we determined if urinary excretion of NGAL can be used as an early indicator of diabetic nephropathy, which causes chronic...

ea0056p420 | Diabetes complications | ECE2018

APOB/APOA1 ratio is associated with metabolic syndrome in type 2 diabetes mellitus women with ischemic cardiomiopathy

Reynoso-Villalpando Gabriela Lyzet , Sevillano-Collantes Cristina , Valle Yeminia , Moreno-Ruiz Inmaculada , Padilla-Gutierrez Jorge Ramon , del Canizo-Gomez Francisco Javier

Background: Retrospective, transversal and analytical study was designed to determine the relationship between ApoB/ApoA1 ratio, Non-HDL-Cholesterol/HDL-Cholesterol ratio and Metabolic Syndrome (MetS) in type 2 diabetes mellitus (T2DM) patients attending routine follow-up in outpatient clinic from Madrid.Methods: The study was performed at the University Hospital Infanta Leonor, a public health center, and specialized secondary referal, which provides se...

ea0056p421 | Diabetes complications | ECE2018

Soluble dipeptidyl peptidase-4 activity is associated with decreased renal function in patients with type 2 diabetes

Cho Eun-Hee , Jeong Ji Yun , Lee Mi Young , Kim Jung Min , Shin Mi-Seon

Objective: Dipeptidyl peptidase (DPP)-4 is highly abundant in the kidney. In various chronic inflammatory diseases, soluble DPP-4 activity is used as a marker for diabetes, coronary artery disease and cancer. This study examined the association between serum soluble DPP-4 levels and renal function or cardiovascular risk in patients with type 2 diabetes mellitus.Research design and methods: Soluble DPP-4 activities were measured retrospectively in a total...

ea0056p422 | Diabetes complications | ECE2018

Predictors of the development of androgen deficiency in men with type 1 diabetes mellitus

Vaschenko Elena , Savasteeva Irina , Mokhort Tatjana

The aim of the study is the search of predictors of the development of androgen deficiency in men with 1 diabetes mellitus type 1. The study included 211 men with type 1 diabetes mellitus aged 18–55 years. The median age of men was 39.00 (30.00; 45,00) years, the median duration of diabetes mellitus type 1 was 12,00 (7,00; 22,00) years. As a result of the research, it was found that an increase in the patient’s age significantly increased the risk of developing andro...

ea0056p423 | Diabetes complications | ECE2018

Relationship between serum levels of HDL cholesterol subclasses and carotid intima media thickness in patients with type 1 diabetes mellitus

Emlek Gamze , Kiyici Sinem , Ustundag Yasemin , Sigirli Deniz , Ozhan Erhan , Eroglu Derya Ustun , Guclu Metin , Kisakol Gurcan

Aim: We aimed to investigate the possible relationship between HDL cholesterol subclasses and carotid intima media thickness (CIMT) in patients with type 1 diabetes mellitus (DM).Material and methods: Sixty-two (female/male: 33/29, mean age: 33.3±8.5 years) patients with type 1 DM at least 5 years and 20 (female/male: 10/10, mean age: 30.4±5.6 years) healthy controls were included in the study. After physical examination and anthropometric meas...

ea0056p424 | Diabetes complications | ECE2018

Dyslipidemia: type 1 diabetes vs. type 2 diabetes

Khiari Marwa , Zribi Sabrine , Zahra Hager , Mizouri Ramla , Faten Mahjoub , Olfa Berriche , Jamoussi Henda

Lipid abnormalities are common in diabetic patients, increasing their cardiovascular risk. The aim of our study is to compare the lipid profile between type 1 and type 2 diabetics. This is a retrospective study of 100 patients, half of them have type 1 diabetes (group 1) and the other half have type 2 diabetes (group 2), hospitalized in department A of the National Institute of Nutrition of Tunis between January 2017 and June 2017. Type 2 diabetics were older than type 1 diabe...

ea0056p425 | Diabetes complications | ECE2018

The comparison of serum cerebellin and catecholamine levelsin patients with newly diagnosed hypertension and type 2 diabetic whose had newly diagnosed hypertension

Cicek Sedat , Ugur Kader , Yardim Meltem , Sahin Ibrahim , Karatas Ahmet , Kilinc Faruk , Aydin Suleyman

Background/purpose: The combination of DM and HT accelerates vascular complications and increases the risk of mortality and morbidity. Hypertension is seen in half of diabetic patients. HT can be detected in approximately 40% of newly diagnosed diabetic patients. DM frequency increased 2.5 times in hypertensive patients. The association of HT and DM is due to the common mechanism responsible for the pathogenesis of both diseases. There is a limited number of studies investigat...

ea0056p426 | Diabetes complications | ECE2018

The prevalence of microvascular complications in the adults with type 1 diabetes and the glycemic control in the Republic of Belarus

Mantachik Marina , Shepelkevich Alla , Dydyshka Yuliya , Lobashova Veranika

According to the current expert recommendations it is advisable to screen microvascular complications: diabetic peripheral polyneuropathy (DPN), diabetic retinopathy (DR), diabetic nephropathy (DN) in all patients with type 1 diabetes mellitus (T1D) and disease duration of 5 years. Therefore, the aim of the study was to assess the clinical and laboratory parameters of patients with type 1 diabetes at the age of 30−45 years with duration of the disease 5–15 years, ta...

ea0056p427 | Diabetes complications | ECE2018

Inflammation in patients with diabetic nephropathy receiving different classes of glucose-lowering medications: serum levels of interferon gamma

Pchelin Ivan , Vasilkova Volha , Shishkin Alexander , Bayrasheva Valentina , Hudiakova Natalia

Proinflammmatory cytokines including interferon gamma (IFNg) are known to be involved in the pathogenesis of diabetic nephropathy. The aim of this study was to assess serum level of IFNg and its clinical correlates in patients with type 2 diabetes and early CKD receiving different types of treatment. We investigated 64 patients with type 2 diabetes and CKD stages 1-3. Group 1 included 20 patients on insulin therapy. Group 2 included 44 patients on metformin or combined oral hy...

ea0056p428 | Diabetes complications | ECE2018

The relationship between morbidity and mortality and HbA1c level in major surgery applied with diabetic patients

Avci Begum Seyda , Saler Tayyibe , Avci Akkan , Bankir Mehmet , Tuzun Zeynep , Nazik Hakan

Background: Diabetes Mellitus (DM) is a disease that increasing in prevalence rapidly in our country and in the world with the increase of sedentary life and unhealthy nutrition. The risks of surgery applied in diabetic patients differ according to other patients.Aim: We aimed to investigate the relationship between the preoperative HbA1c levels and the complications and mortality rates in the postoperative period in patients with diabetes diagnosis and ...

ea0056p429 | Diabetes complications | ECE2018

The relationship between intertemporal choice and blood glucose control in type 2 diabetes

Lee Hyun Ju , Kim Mi-Kyung , Kim Yang Tae , Kim Hye soon , Cho Nan Hee

The objectives of this study were to investigate intertemporal choice in patients with type 2 Diabetes and whether blood glucose control is related to intertemporal choice. Ninety seven diabetes patients (41 inpatients and 56 outpatients) were recruited. All patients were subjected to the following tests: DM Distress Scale (DDS), Beck Anxiety Inventory (BAI), the Center for Epidemiologic Studies Depression Scale (CES-D) and the Big Five Inventory-K-10 (BFI-K-10). 73 of recruit...

ea0056p430 | Diabetes complications | ECE2018

Characteristics of diabetic foot patients admitted to department of endocrinology and metabolic diseases at ankara university, faculty of medicine

Canlar Sule , Cinel Murat , Mutlu Adile Begum Bahcecioglu , Emral Rifat , Bayram Dilek , Metinarikan Nuran , Yurdakul Birgul , Demir Ozgur , Corapcioglu Demet

Introduction: Diabetic foot is one of the important and destructive complications of diabetes. During the life time of a diabetic patient, the risk of developing foot ulcers is around 5–15%, and about 20–25% of the causes of hospitalization in diabetic patients are due to foot ulcers. 40–80% of foot ulcers can be infected and resulted in osteomyelitis. Hospitalization due to osteomyelitis is 12 times more in diabetic patients than in non-diabetic population....

ea0056p431 | Diabetes complications | ECE2018

Atherosclerosis in women of reproductive age with type 2 diabetes mellitus and polycystic ovary syndrome

Paschou Stavroula A , Kalogeris Nikolaos , Proikaki Stella , Loi Vasiliki , Anagnostis Panagiotis , Vryonidou Andromachi

Introduction: The aim of this study was to investigate the degree of atherosclerosis in women of reproductive age with type 2 diabetes mellitus (T2DM), with and without polycystic ovary syndrome (PCOS).Patients and Methods: 71 women (mean age 43.2 y) with T2DM treated with diet or oral anti-diabetic medications and 36 controls were studied. According to menstrual cycle and clinical hyperandrogenism, patients with T2DM were classified into two subgroups, ...

ea0056p432 | Diabetes complications | ECE2018

Association of adverse pregnancy outcomes with glycemic cut-offs stated by the IADPSG, POGS and WHO diagnostic criteria for gestational diabetes mellitus in De La Salle University Medical Center (DLSUMC), Cavite, Philippines from January 2012 to December 2015

Francisco Danica , Andag-Silva Aimee

Objectives: To determine the association between adverse pregnancy outcomes with each of the 75 g OGTT cut-off values prescribed by the World Health Organization (WHO), Philippine Obstetrical and Gynecological Society (POGS), and the International Association of Diabetes in Pregnancy Study group (IASDPG) criteria to help define more appropriate glycemic cut-off levels for Filipinas.Methodology: Retrospective Cohort study of pregnancy deliveries in De La ...

ea0056p433 | Diabetes complications | ECE2018

Ankle-brachial index values in diabetic patients with and without claudication

Bayrak Savas , Okuturlar Yildiz , Bozer Denis , Sadri Sogol , Ozbas Tevetoglu Isil , Boyuk Banu , Mert Meral

Aim: The ankle-brachial index (ABI) shows the existence of peripheral arterial disease and is also related to cardiovascular mortality in diabetic patients, even in those with coronary artery disease at an early stage. Normal levels are considered to be an ABI of 0.9 – 1.3; ABI thresholds of less than 0.9 and more than 1.3 are highly suspicious for PAD and high CV risk in diabetic patients. In this study, we planned to investigate the ankle-brachial index values in diabet...

ea0056p434 | Diabetes complications | ECE2018

Analysis of kidney biopsy findings in diabetic patients

Akgur Suat , Oruc Aysegul , Yildiz Abdulmecit , Ersoy Canan , Aytac Vuruskan Berna , Gullulu Mustafa , Ersoy Alparslan

Kidney disease occurs in diabetic patients during disease course in time. Diabetes duration, co-morbid diseases, presence of retinopathy, family history of diabetic nephropathy (DN) predict kidney involvement. Although DN is the initial diagnosis in diabetics with proteinuria, other diseases like primary glomerulonephritis (GN) could be the reason of kidney involvement. DN is increasing in proportion with the increase in diabetes prevalence, and it has been predicted to contin...

ea0056p435 | Diabetes complications | ECE2018

Hypomagnesemia as a marker of diabetic nephropathy

Mashaheet Mohamed , Hammad Ahmed , Elshafee Shahira , Abdelsamad Basma

Magnesium is an essential element and has a fundamental role in carbohydrate metabolism in general and in the insulin action in particular. Magnesium is involved in multiple levels in insulin secretion, binding and activity. Cellular magnesium deficiency can alter the activity of the membrane bound Na+K+ ATPase, which is involved in the maintenance of gradients of sodium and potassium and in glucose transport. Magnesium depletion has a negative impact on glucose homeostasis an...

ea0056p436 | Diabetes complications | ECE2018

Association cystatin C with the presence of carotid atherosclerosis in patients with diabetes type 2 and chronic kidney diseaseassociation cystatin C with the presence of carotid atherosclerosis in patients with diabetes type 2 and chronic kidney disease

Vasilkova Volha , Mokhort Tatiana , Pchelin Ivan , Bayrasheva Valentina , Filiptsova Natallia

Objective: Cystatin C has been proposed as a novel marker of renal function and as a predictor of the severity of coronary atherosclerosis and future cardiovascular events. The aim was to evaluate the possible role of chronic kidney disease and particularly CysC on the characteristics of carotid atherosclerosis in patients with type 2 diabetes (DT2).Materials and methods: We investigated 195 patients both sexes with DT2 aged 56.54±4.17 years. Contro...

ea0056p437 | Diabetes complications | ECE2018

Diabetic ketoacidosis among SGLT2i-treated patients: insight from a single medical center located in the region with the highest diabetes mellitus mortality rate in Israel

Jaffe Anat , Dafni Naomi , Haran Galith

SGLT2i drugs have been funded by the Israeli health basket since 2017 for patients with type-2-diabetes and previous cardiovascular disease, as a result of the EMPA-REG outcome studies documenting 34% reduction in all-cause mortality. In 2015 the FDA warned that SGLT2i may result in diabetic-ketoacidosis (DKA). The reported DKA cases were not typical because many had type-2-diabetes and their blood glucose was slightly increased.Objective: To describe DK...

ea0056p438 | Diabetes complications | ECE2018

Investigation of serum SCUBE-1 level in relation to microvascular complications in patients with type 2 diabetes mellitus

Bingol Umut , Kevser Demir Ayse , Kutluturk Faruk , Cansel Ozmen Zeliha , Demir Osman

Objective: The aim of this study was to investigate the association between serum level of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) and both type 2 diabetes mellitus and its related microvascular complications.Material and methods: The study was included 50 type 2 diabetic patients with complications (group 1), 50 diabetic patients without complications (group 2) and 50 healthy individuals as control group (group 3). Anthropometry and...

ea0056p439 | Diabetes complications | ECE2018

Hyperlipidemia during gestational diabetes: maternal and offspring complications

Herrera-Martinez Aura D. , Palomares Ortega Rafael , Bahamondes Opazo Rodrigo , Moreno Moreno Paloma , Galvez Moreno Maria A.

Lipid profile suffers adaptive changes during pregnancy due to estrogen stimulation and insulin resistance. Several relations have been suggested between maternal lipid profile, glucose tolerance, endothelial cell dysfunction and long-term cardiovascular risk; the effects of maternal lipid profile metabolism in fetal growth are also inconclusive. Since a regular evaluation and follow-up of lipid profile during pregnancy has not been stablished yet, we aimed to evaluate the inc...

ea0056p440 | Diabetes complications | ECE2018

Osteopontin levels in plasma, muscles and bone in patient with non-healing diabetic foot ulcers: a new player in wound healing process?

Shargorodsky Marina , Feldbrin Zeev , Omelchenko Elena

Background: The present study was designed to investigate the impact of osteopontin (OPN) in different tissue (e.g., plasma, muscles and bone) on amputation rate (in-hospital and during one year follow-up) for non-healing diabetic foot ulcers (DFUs).Methods: This pilot study consisted of 30 diabetic patients, hospitalized due to non-healing DFUs. Patients were divided into two groups: Group 1 included 14 patients who underwent limb-preserved debridement ...

ea0056p441 | Diabetes complications | ECE2018

Impaired awareness of hypoglycaemia does not affect the prevalence of diabetes-related distress in people with diabetes type 1

Tsitlakidis Damianos , Kuniss Nadine , Alfons Muller Ulrich , Muller Nicolle , Kloos Christof , Kramer Guido

Objective: The aim of this study was to assess prevalence of impaired awareness of hypoglycaemia (IAH) by the Gold method in people with type 1 diabetes and to compare people with and with IAH regarding metabolic control.Methods: In a cross-sectional study, we assessed IAH in 139 people with type 1 diabetes (54.1y, diabetes duration 24.0y, HbA1c 7.1%) attending the University outpatient department for endocrinology and metabolic diseases. IAH was assesse...

ea0056p442 | Diabetes complications | ECE2018

The comparison of the fate of arteriovenous fistula in diabetic and non-diabetic recipients following kidneytransplantation

Ersoy Alparslan , Odman Hikmet Utku , Yolgosteren Atif , Oruc Aysegul , Akgur Suat , Yildiz Abdulmecit , Ersoy Canan

Native arteriovenous fistula (AVF) represents the best vascular approach for chronic hemodialysis. It is difficult to create an AVF in diabetic hemodialysis patients due to atherosclerotic changes in the arteries. Although AVF becomes useless after a successful kidney transplant, there is no accepted policy for preserving or ligating AVF. The aim of this study was to compare the fate of AVFs in diabetic and non-diabetic patients after kidney transplantation.<p class="abste...

ea0056p443 | Diabetes complications | ECE2018

TSH and adiponectin levels in patients with diabetic kidney disease after renal transplantation

Sazonava Alena , Mokhort Tatiana , Karlovich Natalia , Shyshko Volha , Dolgolikova Anna

Aims: Diabetic nephropathy (DN) is a leading cause of chronic kidney disease (DKD). Various hormonal disturbances are not rare among DKD patients. Adipose tissue as an active endocrine organ with multiple metabolic effects may play an extra important role in hormonal disbalance during progressive kidney function decline. The purpose of the study was to investigate potential relationship between thyroid status and adiponectin levels in patients with type 1 diabetes (T1D) and DK...

ea0056p444 | Diabetes complications | ECE2018

Knowledge and Attitudes of Trainee Doctors in the Management of DKA and Compliance with current Protocol in a large University Teaching Hospital

Kennedy Carmel , McDonnell Tara , Cormac Kennedy , Bholah Salmaan , Julius Valerie , Pazderska Agnieszka , Louise Healy Marie , Phelan Niamh

Diabetic Ketoacidosis (DKA) is a diabetic emergency with associated morbidity and mortality. Current evidence supports a protocol-based approach to its management. Our survey was conducted in a tertiary university hospital, where patients with DKA are initially managed as part of unselected general medical take.Objectives: To assess knowledge and confidence of trainee doctors in DKA management. To review adherence to DKA protocol and identify areas for f...

ea0056p445 | Diabetes complications | ECE2018

The association between glycemic markers and variability with plasma adipocytokine levels and markers of endothelium dysfunction in women with pregestational diabetes mellitus

Tanrikulu Seher , Tekin Sakin , Yalin Gulsah Yenidunya , Bagdemir Elif , Idiz Cemile , Dervisoglu Elmire , Hatiboglu Songul , Genc Sema , Dinccag Nevin

Introduction: Pregnant women with pre-existing diabetes are at greater risk of perinatal morbidity and diabetic complications. Glycemic control is the greatest impotance for both mothers and infants due to the risk of congenital anomalies, perinatal mortality and significant morbidity in the short and long term. Continuous glucose monitoring system (CGMS) is a novel tool to assess 24-h glucose fluctuations. In pregestational diabetes, CGMS may have an important role for excell...

ea0056p446 | Diabetes complications | ECE2018

Acoustic Radiation Force Impulse Elastography and Ultrasonographic Findings of Achilles Tendon in Patients with and without diabetic peripheral neuropathy: a cross-sectional study

Iyidir Ozlem Turhan , Rahatli Feride Kural , Bozkus Yusuf , Ramazanova Lala , Turnaoglu Hale , Nar Asli , Tutuncu Neslihan Bascil

Diabetic foot is one of the most feared complication of diabetes. The tendons and ligaments’ stiffness and elasticity are known to be altered in diabetic foot. Achilles tendon (AT) plays an important for foot biomechanics and the altered stiffness of AT may have a role in pathogenesis of diabetic foot. Determination of the early changes in AT may help to identify the risky patients for diabetic foot. Acoustic Radiation Force Impulse (ARFI) Elastography is an elastography ...

ea0056p447 | Diabetes complications | ECE2018

Impact of systemic and local cytokine status in diabetic foot syndrome on ulcers healing rate

Mashkova Maryia , Mokhort Tatiana , Goranovb Vitaliy , Shyshko Alena , Chvatova Liliya , Pukita Inessa , Symantovich Volha

Aim: To study the relationship of cytokines level in patients with diabetic foot syndrome (SDS) with a healing rate of ulcerative defect and diabetes compensation.Materials and methods: Twenty-four patients with DFS (DFS group) and 24 diabetic patients without foot ulcers (control group) (both groups comparable in age and other clinical and general laboratory characteristics, ongoing treatment, offloading mode). All DFS patients had chronic non-infected ...

ea0056p448 | Diabetes complications | ECE2018

The relationship between cardiovascular autonomic neuropathy and the severity of coronary atherosclerosis

Stepura Olena , Mankovskiy Georgiy

Introduction: Cardiovascular autonomic neuropathy (CAN) is a significant risk factor for cardiovascular morbidity and mortality in patients with diabetes mellitus. However, an association between CAN and severity of coronary atherosclerosis in patients with ischemic heart disease (IHD) was not investigated.Objectives: The aim of this study was to investigate the relationship of CAN and coronary stenosis in patients with clinical signs of IHD.<p class...

ea0056p449 | Diabetes complications | ECE2018

Type 1 diabetes is associated with a differential pattern of carotid atherosclerotic plaque types

Castelblanco Esmeralda , Ramirez-Morros Anna , Hernandez Marta , Granado Minerva , Betriu Angels , Puig-Domingo Manel , Alonso Nuria , Mauricio Didac

Introduction: The presence and type of atherosclerotic plaque is associated with future cardiovascular events (CVE). We previously described that increased frequency of plaques is associated with specific features in type 1 diabetes. The aim of the present study was to investigate the characteristics of atherosclerotic plaques in patients with type 1 diabetes mellitus (T1D).Methods: A cross-sectional study of 174 subjects with carotid atherosclerotic pla...

ea0056p450 | Diabetes complications | ECE2018

Neurosensorial hearing loss in type 2 diabetic patients

Golemi Ersida , Kuci Anjeza , Myrtaj Elira , Ylli Agron

Introduction: There is a connection between neurosensorial hearing loss and tipe 2 diabetes. Diabetes is a systemic chronic disease that affects the vessels and nerves. There are 415 million people all over the world that suffer from diabetes. There is not a clear mechanism of how diabetes is related to hearing loss but it s possible that the high blood glucose levels associated with diabetes cause damage to the small blood vessels in the inner ear, similar to the way in wich ...

ea0056p451 | Diabetes complications | ECE2018

Serum level of the autophagy biomarker beclin-1 in patients with diabetic nephropathy

Hussin Mervat , Rashed Laila

Introduction: Autophagy is a major clearance mechanism that destroys organelles and damaged proteins to keep cellular survival and homeostasis. Previous experimental studies have showed that autophagy has crucial role in the progression of diabetes and kidney diseases.Aim: This pilot cross-sectional study aimed to investigate the association between serum concentrations of beclin-1, a key regulator of autophagy, and diabetic nephropathy.<p class="abs...

ea0056p452 | Diabetes complications | ECE2018

The comparison of longevity of arteriovenous fistula in hemodialysis patients with or without diabetes mellitus

Yolgosteren Atif , Yildiz Abdulmecit , Ersoy Canan , Ersoy Alparslan

Vascular access remains both a life line and a ‘weak link for patients receiving hemodialysis (HD) therapy. It difficult to create an arteriovenous fistula (AVF) in diabetic hemodialysis patients due to atherosclerotic changes in arteries. This study investigated the fate of AVFs in diabetic and non-diabetic HD patients.Methods: The study included 306 patients (142 females, 164 males) on regular HD treatment with AVF. We excluded patients dialyzed w...

ea0056p453 | Diabetes complications | ECE2018

Endothelial dysfunction in the diabetic foot

Jude Edward , Mascarenhas Janice , Bhatnagar Deepak , Weston R , Wilkinson Fiona , Alexander Yvonne

Endothelial dysfunction (ED) is common in type 2 diabetes mellitus (T2DM) and can lead to microvascular and macrovascular complications. The aim of our study was to assess ED in patients with T2DM (n=21; 13 with diabetic neuropathy (DN), 8 without DN) and compare them with non-diabetic controls (n=10).Methods: ED was assessed by skin microcirculation (SM) and biochemical markers (BM) of endothelial function. SM was measured on the dorsu...

ea0056p454 | Diabetes complications | ECE2018

Polyglandular Autoimmune Syndrome Type III(PAS) onset with diabetic ketosis caused by the insulin analog induced anti-insulin antibody: successful treatment with human insulin

Erdekli Fatma Tugba Catan , Selek Alev , Cetinarslan Berrin , Canturk Zeynep , Tarkun Ilhan

Type III PAS is defined as autoimmune thyroiditis occurs with another organ-specific autoimmune disease. Further PAS IIIA is subclassified as autoimmune thyroiditis with immune-mediated diabetes mellitus. Circulating organ-specific autoantibodies can be detected in these patients. We report a patient with Hashimoto Thyroiditis since five years on levothyroxine treatment with normal TSH levels and new onset insulin dependent Type I DM for 3 months. The patient was admitted Recu...

ea0056p455 | Diabetes complications | ECE2018

Bone markers and bone integrity in type 2 diabetes

Jude Edward , Mascarenhas Janice , Bhatnagar Deepak , Weston R , Wilkinson Fiona , Alexander Yvonne

Type 2 diabetes mellitus (T2DM) and obesity are linked to osteoporosis, making these patients at increased risk of developing fractures. In this study we aimed to investigate bone biochemical markers and bone structure in diabetic patients to compare with non-diabetic controls.Methods: We recruited 21 type 2 diabetic patients and 10 non-diabetic controls. Fasting blood samples were collected for markers of bone turnover (Sclerostin (SCL), RANKL, OPG, OPN...

ea0056p456 | Diabetes complications | ECE2018

Levels of scerostostin in serum and femoral vascular tissue and its relationship with atherosclerosis and cardiovascular mortality in patients with and without type 2 diabetes

Garcia-Fontana Beatriz , Novo-Rodriguez Cristina , Andujar-Vera Francisco , Garcia-Fontana Cristina , Gonzalez-Salvatierra Sheila , Marquez-Hernandez Teresa , Lozano-Alonso Silvia , Morales-Santana Sonia , Rozas-Moreno Pedro , Garcia-Martin Antonia , O'valle-Ravassa Francisco , Castillo Juan De Dios Luna-Del , Munoz-Torres Manuel

Introduction: Sclerostin is a glycoprotein expressed mainly by osteocytes, which acts as inhibitor of bone formation. However, several studies have shown an increase in serum levels of sclerostin in subjects with type 2 diabetes (T2D) and cardiovascular disease (CVD) suggesting an additional role of this protein at the vascular level. The hypothesis that sclerostin could be expressed by vascular smooth muscle cells (VSMCs) under calcifying conditions could justify this elevati...

ea0056p457 | Diabetes complications | ECE2018

Serum lipid changes during pregnancy and after delivery in women with previous gestational diabetes

Prados Montserrat , Flores-Le Roux Juana A , Benaiges David , Llaurado Gemma , Jose Chillaron Juan , Amador Veronica , Bosch Cristina , Paya Antoni , Pedro-Botet Juan

Background: Women with a history of gestational diabetes mellitus (GDM) are at increased risk for diabetes and lipid alterations.Objective: In a cohort of women with previous GDM, we aimed to ascertain whether women with abnormal glucose tolerance one year post-delivery had a more atherogenic lipid profile after pregnancy than those with normal glucose tolerance.Design and patients: A descriptive study of GDM women who underwent pr...

ea0056p458 | Diabetes complications | ECE2018

The relationship between oxidative stress markers and carotis intima media thickness in patients with diabetic microvascular complications

Tuzun Dilek , Yilmaz Tugba , Oguz Ayten , Gul Kamile

Aim: To investigate the relationship between oxidative stres markers and carotis intima media thickness in diabetic patients with microvascular complications.Material and methods: 112 patients with type 2 diabetes mellitus and 44 healthy control subjects were included in the study. The presence of diabetic retinopathy was investigated by ocular examination. Neurological examinations were performed for neuropathy. In addition, catalase (CAT), superoxide d...

ea0056p459 | Diabetes complications | ECE2018

Predictors of perinatal complications in pregnant women with gestacional diabetes

Cunha Filipe Manuel , Eira Jose Joao , Pires Vanessa , Carvalho Sonia , Nogueira Claudia

Background: Pregnant women with gestational diabetes (GD) have a higher risk of perinatal complication compared to women without. Nevertheless, in women with GD, predictors of perinatal complication are not well established. We aimed to compare, in women with GD, those with and without perinatal complications and to study predictors of perinatal complications in women with GD.Methods: Retrospective study of pregnant women followed in the Endocrinology cl...

ea0056p460 | Diabetes complications | ECE2018

Role of the lipid profile as a predictive factor in the development of diabetic retinopathy in patients with type 1 diabetes

Zubiria Juan Manuel , Goni Maria Jose , Eguilaz Nerea , Irigaray Ana , De Carlos Joaquin , Forga Lluis , Tamayo Ibai

Introduction: Diabetic retinopathy (DR) is the most common microvascular complication in patients with type 1 diabetes (T1D), and the role of lipids in the development of this complication is still controversial. In this study we have analyzed the association between lipid levels at onset and during the follow-up and the subsequent development of DR.Methods: The cohort consists of 1132 patients with T1D who were diagnosed in Navarra between 1/1/1990 and ...

ea0056p461 | Diabetes complications | ECE2018

Markers of nitrosative stress, angiogenesis and inflammation linked to severity of complications in type 1 diabetes

Sokolovska Jelizaveta , Osina Kristine , Dekante Alise , Krievina Gita , Tretjakovs Peteris , Pirags Valdis , Sjakste Nikolajs

Background: Hypoxia, oxidative stress and inflammation induced by hyperglycaemia are ‘key players’ in development of diabetic complications.Aim: To analyze differences in levels of nitric oxide (NO) and its metabolites nitrate and nitrite (NO2/NO3) and well as angiopoietin 2 (Ang2) and neuropeptide Y (NPY) in patients with type 1 diabetes and different complications status; to analyze associations between these markers.Me...

ea0056p462 | Diabetes complications | ECE2018

Nonalcoholic fatty liver disease in men with type 2 diabetes mellitus and androgen deficiency

Allakhverdieva Yanina , Khripun Irina , Vorobyev Sergey , Mineev Nikolay

Background: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver diseases, and the presence of type 2 diabetes mellitus (T2DM) increases its incidence up to 90%. To date, the effect of androgen deficiency in men with T2DM on the development of NAFLD has not been studied.Aim: To assess the effect of the endogenous testosterone (T) level on the incidence of NAFLD in men with T2DM.Materials and methods: The study...

ea0056p463 | Diabetes complications | ECE2018

Influence of ethnicity on gestational diabetes mellitus in the center of Israel: a retrospective cohort study

Hochman Yuval , Wiener Yifat , Koren Shlomit , Koren Ronit

Aim: The aim of this study was to compare maternal and neonatal outcomes between Israeli Arab and Jewish women with GDM not controlled with lifestyle modification.Methods: We conducted a retrospective cohort study of women with GDM who were not controlled with lifestyle modification and were followed and gave birth in a university affiliated medical center between 2005 and 2015.Results: The study included 343 women, 45 (11.8%) of t...

ea0056p464 | Diabetes complications | ECE2018

Subclinical atheromatous disease detection improves cardiovascular event prediction in chronic kidney disease with and without diabetes

Palanca Ana , Castelblanco Esmeralda , Betriu Angels , Valdivielso Jose M , Perpinan Hector , Puig-Domingo Manel , Fernandez Elvira , Mauricio Didac , Alonso Nuria

Background: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients with and without diabetes mellitus (DM). Traditional cardiovascular risk factors fail to fully account for the increase in cardiovascular risk in these patients. The NEFRONA study is a large, multicentre, prospective, observational study that evaluated atheromatous disease (AD) in the carotid and femoral territories in a large cohort of Spanish CKD ...

ea0056p465 | Diabetes complications | ECE2018

Wrist and ankle measurements in patients with and without diabetes-related macrovascular disease

Okuturlar Yildiz , Tevetoglu Isil Ozbas , Bozer Denis , Cicek Gamzegul , Sadri Sogol , Ugur Gamze , Ozdemir Bahar , Piskinpasa Hamide , Karakaya Pinar , Okuturlar Ozgur , Mert Meral

Aim: We aimed to evaluate wrist and ankle measurements in patients with and without diabetes-related macrovascular disease.Material and method: 151 consecutive patients with type 2 diabetes who came to our diabetic outpatient clinic were included. We have divided the patients into two groups. Group 1 (patients with diabetes related macrovascular complications) and group 2 (patients without diabetes related macrovascular complications). Group 1 (n</em...

ea0056p466 | Diabetes complications | ECE2018

Prevalence and risk factors of diabetes in chronic viral hepatitis B and C: about a retrospective study

Boukhayatia Fatma , Aissaoui Dhilel , Kchir Hela , Nakhli Abdelwaheb , Yacoub Haythem , Maamouri Nedia , Mami Nabil Ben

Introduction: Carbohydrate metabolism disorders are common in chronic liver diseases, from glucose intolerance to proven diabetes. The presence of diabetes during chronic liver disease is a factor of poor prognosis. The purpose of our study is to assess the prevalence of diabetes in chronic hepatitis B and C and to determine the risk factors.Patients and methods: This is a retrospective study that collects all cases of chronic hepatitis hospitalized in t...

ea0056p467 | Diabetes complications | ECE2018

Hypoglycemia in patients with type 2 diabetes mellitus in geriatric population

Okay Damla , Altinova Alev Eroglu , Bolayir Basak , Deniz Olgun , Kaya Ayse , Akturk Mujde , Goker Berna , Toruner Fusun Balos

Introduction: Hypoglycemia is a complication of diabetes mellitus (DM) with high morbidity and mortality. Risk of hypoglycemia is affected by the type and duration of DM, use of insulin or oral antidiabetic agents, dietary habits and comorbidities. In this study, we aimed to understand frequency and causes of hypoglycemia in patients with type 2 DM in Turkish population and especially collect data about hypoglycemia in geriatric population.Methods: Betwe...

ea0056p468 | Diabetes complications | ECE2018

Predictors for low bone mineral density assessed with DXA and trabecular bone score in patients with diabetes mellitus

Dragne Madalina , Dusceac Roxana , Sorohan Bogdan , Poiana Catalina

Background: Diabetes mellitus is a metabolic disease associated with an increased risk of fracture, despite normal or increased bone mineral density (BMD), especially type 2 diabetes mellitus (T2DM). Trabecular bone score (TBS) is an imaging investigation that measures the grayscale variations on the lumbar spine performed on the DXA machine. The aim of this study was to evaluate the determinants associated with low BMD and TBS in patients with type 1 and type 2 diabetes melli...

ea0056p469 | Diabetes complications | ECE2018

Is-it safe for diabetic patients to fast during Ramadan?

Cheikh Marwa Ben , Laajili Olfa , Naceri Taghrid , Hassen Hana Bel Hadj , Jamoussi Henda , Mami Faika Ben , Kamoun Ines , Salem Leila Ben

Introduction: As Ramadan fasting is one of the five pillars of Islam, more than one billion muslims fast simultaneously worldwide. Patients with diabetes especially those with type 1 diabetes who fast during Ramadan, are at increased risk of diabetic ketoacidosis, particularly if their diabetes is poorly controlled before Ramadan. The aim of our study was to compare the incidences of diabetic Ketosis or ketoacidosis during in the month of Ramadan, the preceding month (Shaaban)...

ea0056p470 | Diabetes complications | ECE2018

Risk factors for delay gastric emptying in patients with type 2 diabites

Kostitska Iryna , Mankovsky Boris , Shapoval Oksana , Zherdova Nadiya , Grunevych Roman , Babenko Oleksandr , Marysyn Oksana

Introduction: The objective of the research was to determine the predictive value of the most probable etiopathogenetic factors contributing to the development and progression of gastric dysfunction in patients with type 2 diabetes. Only 5% of type 1 and 1% of type 2 diabetic combine the delay of gastric emptying (DGE) with typical gastroparesis symptoms. Systematic review of risk factors of development and progression symptoms of diabetic gastroparesis (DG). Results presented...

ea0056p471 | Diabetes complications | ECE2018

Clinical and laboratory predictors of positive renal effects of vildagliptin

Bayrasheva Valentina , Pchelin Ivan , Babenko Alina , Chefu Svetlana , Grineva Elena

Accumulating facts show that incretin-modulating therapy could be beneficial in both glycemic control and nephroprotection in type 2 diabetes (DM2). Clinical evidence for nephroprotective potential of DPP-4 inhibitors is limited and predictive determinants are unknown. The study conducted with DM2 patients aimed to assess renal effects of vildagliptin addition and identify their clinical and laboratory predictors. The study enrolled 44 insulin-treated male and female type 2 di...

ea0056p472 | Diabetes complications | ECE2018

An assessment of abnormal liver function tests in a cohort of unselected diabetic patients

Ludgate Stephen , Naimimohasses Sara , Redha Mostafa , Crowley Vivian , Norris Suzanne , Healy Marie-Louise

Introduction: The prevalence of abnormal liver function tests (LFTs) in the general population has been estimated to be 8.1–9.8%. Abnormal LFTs are common in diabetes although there are still few studies describing the exact prevalence. AST-to-platelet-ratio-index (APRI) and Fibrosis-4-score (FIB4) are scoring systems which can be used to estimate the degree of liver fibrosis. An APRI score >1 has a sensitivity of 76% and a specificity of 72% for predicting cirrhosis ...

ea0056p473 | Diabetes complications | ECE2018

The effect of glutathione S-transferase M1 and T1 polymorphisms on ascorbic acid plasma levels in diabetic patients

Valente Ana , Bicho Manuel , Carolina Santos Ana , Matos Andreia , Duarte Rui , Raposo Joao F , Costa Helena S

Introduction: Type 2 diabetes mellitus have been associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress. Meta-analyses have indicated that deletion of either GSTM1 or GSTT1 is associated with a significant increased risk of coronary heart disease. The aim of this study was to evaluated if ascorbic acid (AA) plasma levels differ by GST genotype in d...

ea0056p474 | Diabetes complications | ECE2018

Maternofetal complications of diabetic pregnancy: about 293 cases

Atraki Sara , EL Aziz Siham , Bensbaa Selma , Chadli Asmaa

Introduction: Pregnancy in women with diabetes is considered high risk because of potentially serious maternal and fetal complications that can put in to risk the maternal and fetal prognosis.Objective: Describe and analyze risks associated with diabetic pregnancies and compare maternal fetal prognosis of pregnancies with pregestational diabetes (T1D and T2D) with gestational diabetes mellitus (GDM).Patients and methods: It was a d...

ea0056p475 | Diabetes complications | ECE2018

Bacterial lower limb dermo-hypodermitisin diabetic patients: what epidemiological, clinical and therapeutic particularities? About 134 cases

Kaidi FZ , El Aziz S , Mjabber A , Chadli A

Introduction: The uncontrolled diabetics are led to develop severe infections like severe forms of acute bacterial dermo-hypodermitis. The aim of our study was to clarify the epidemiological, clinical and therapeutic characteristics of BDH in diabetic patients.Patients and methods: A prospective, descriptive and analytical study was conducted in the Diabetology, Endocrinology and Metabolism Department, Ibn Rochd University Hospital of Casablanca, from Ja...