Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

ea0056p959 | Male Reproduction | ECE2018

Infertility caused by Chapelle syndrome

Kavecan Ivana , Obrenovic Milan , Privrodski Boris

Introduction: Testicular disorder of sexual development (XX male syndrome; Chapelle syndrome) is a rare clinical condition. Incidence is 1:20 000 in newborn males. Characteristics of syndrome include hypogonadism, gynecomastia, and infertility resulting from the azoospermia. Diagnosis is mainly established after puberty. Clinical manifestations could be heterogeneous, but external genitalia appear to be completely virilized in 90% of 46,XX males: SRY-positive. Other manifestat...

ea0056p960 | Male Reproduction | ECE2018

Endogenous testosterone supports spermatogenesis even in the absence of gonadotrophins: evidence from a case report

Antonio Leen , Albersen Maarten , Billen Jaak , Maleux Geert , Van Rompuy Anne-Sophie , Vanderschueren Dirk

Background: In patients with testicular dysgenesis syndrome, reduced semen quality and testicular cancer are common. We report a case of a testicular tumour in a patient with a history of cryptorchidism and oligoasthenospermia. He had an unusual hormonal profile, which was not fully explained by the pathological findings.Case: A 31-year-old man was referred to our tertiary care andrology unit for primary infertility with a history of bilateral orchidopex...

ea0056p961 | Male Reproduction | ECE2018

Differential effects of genetically inherited – and high fat diet induced – obesity on spermatogenesis in adult male rats

Deshpande Sharvari , Nemani Harishankar , Pothani Suresh , Balasinor Nafisa

Obesity, a new world syndrome, is defined as excessive white adipose tissue accumulation, that may impair health leading to severe metabolic and reproductive complications affecting millions of people of different age groups. Recent studies have shown that incidence of male obesity induced fertility issues are rising in couples undergoing assisted reproductive technologies suggesting that obesity is emerging as an established risk factor for male infertility or subfertility. O...

ea0056p962 | Male Reproduction | ECE2018

Hematological indices in congenital hypogonadism and the effect of testosterone replacement therapy: A retrospective study

Haymana Cem , Demirci Ibrahim , Dinc Mustafa , Demir Orhan , Akin Onur , Meric Coskun , Aydogdu Aydogan , Sonmez Alper , Azal Omer

Introduction: Patients with hypogonadism are at increased risk for cardiovascular diseases. Mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) are hematological indices that are surrogate markers of adverse cardiovascular outcomes. This study investigated the platelet count, MPV levels, PLR, and NLR in patients with congenital hypogonadotrophic hypogonadism (CHH) and also studied the effect of testosterone replacement thera...

ea0056p963 | Male Reproduction | ECE2018

Hypogonadism and mortality in type 2 diabetic men

Corrales Juan Jose , Herrero Ana , Caceres Rocio , Sanchez Ana Isabel , Marcos Miguel , Recio Jose Maria , Miralles Jose Manuel

Introduction: Low testosterone serum levels are associated with increased mortality in non-diabetic males. However, knowledge about the association between male hypogonadism and mortality among type 2 diabetic (T2DM) men is limited due to short follow-up periods in the few existing studies.Objective: To assess the association between hypogonadism and mortality in diabetic men.Material and methods: 263 unselected men with T2DM (mean...

ea0056p964 | Male Reproduction | ECE2018

Impact of testosterone administration to female-to-male transsexuals on cardiovascular risk factors

Sabater Eva Maria Riera , Balaguer Marcelino Gomez , Torres Santiago Garcia , Lannatuoni Francesca , Morant Celia Banuls , Murillo Felipe Hurtado , Villaescusa Cristina Del Castillo , Mijares Antonio Hernandez

Introduction: Cross sex hormonal therapy with testosterone is used in female-to-male transgender people to induce the desired secondary sexual features; this could lead to an increased risk of cardiovascular diseases. Data published on this subject is scarce and contradictory.Objective: To evaluate effects on weight, inflammatory and prothrombotic parameters, lipid profile, and insulin resistance after 3–4 months of testosterone treatment in transse...

ea0056p965 | Male Reproduction | ECE2018

Triglyceride-Glucose index levels in patients with congenital hypogonadism

Demirci Ibrahim , Haymana Cem , Demir Orhan , Kirnap Nazli Gulsoy , Meric Coskun , Sonmez Yusuf Alper , Gulcelik Nese Ersoz , Aydogdu Aydogan , Azal Omer

Introduction: It is well known that patients with hypogonadism are at increased risk for insulin resistance and cardiovascular diseases. In many studies homeostatic model assessment-insulin resistance (HOMA-IR) formulation is used for the evaluation of insulin resistance. Recently, a simple and inexpensive approach to evaluate for insulin resistance has been developed, the Triglyceride – Glucose (TyG) index. This particular index is based on measuring the levels of fastin...

ea0056p966 | Male Reproduction | ECE2018

Effects of cross-sex hormone treatment on body composition in transgender persons

Hayon Maria , Blanquez David , Serrano Maria del Carmen , Aviles Maria Dolores , Torres Elena

Background: Cross-sex hormone treatments are used to masculinize or feminize the bodies of female-to-male (FtM) or male-to-female (MtF) transsexuals, respectively. Redistribution of fat mass is expected to occur during the first 1–6 months in transgender males and in the first 3–12 months in transgender females.Objective: To examine the effects of cross-gender sex hormone therapy (CHT) on body composition in transsexual men and women.<p cla...

ea0056p967 | Male Reproduction | ECE2018

Erectile Dysfunction – The hidden sickness we don’t seek

Roque Catarina , Capitao Ricardo , Ferrinho Catia , Duarte Sequeira , Vasconcelos Carlos

Introduction: Erectile dysfunction (ED) is highly prevalent and negatively impacts the patient’s and the partner’s quality of life. It is a well-established red flag for ongoing neuro-vascular disease and a predictor of coronary, cerebral and peripheral arterial disease (PAD). Our aim was to document how often do clinicians investigate ED and use it as a predictor of neuro-vascular pathology to trigger a thorough revision of cardiovascular risk factors (CVRF). This a...

ea0056p968 | Male Reproduction | ECE2018

Abstract withdrawn....

ea0056p969 | Male Reproduction | ECE2018

Leptin targets in the male reproductive tract of mice

Hart Robert , Dobos Robin , Agnew Linda , McFarlane James

Leptin is best known as an appetite and metabolic rate modulator secreted from fat, but it also has a range of other functions including modulation in reproductive physiology. To date, most studies examining the role of leptin in male reproduction have focussed on individual tissues, often in vitro. In the current report, a bolus physiological dose of iodinated leptin was administered intravenously to male mice to and samples collected over a one hour time course to d...

ea0056p970 | Male Reproduction | ECE2018

A case of Wolfram syndrome with primary gonadal insufficiency

Ozcelik Serhat , Sariyadin Mehmet , Aydin Bunyamin , Temiz Sibel , Caglayan Kenan , Celik Mehmet , Kizilgul Muhammed , Gozu Hulya Iliksu

Introduction: Wolfram syndrome is characterized by diabetes mellitus (DM), diabetes insipidus (DI), optic atrophy and sensorineural deafness. DM is the first manifestation and optic atrophy also onsets in the first decade of life. The onsets of DI and sensorineural deafness are in the second decade, urinary tract abnormalities are in the third decade and neurologic abnormalities are in the fourth decade respectively. Hypogonadotrophic hypogonadism is a usual manifestation of t...

ea0056p971 | Male Reproduction | ECE2018

Child wish and fertility preservation in assigned male at birth transgender persons living in Belgium

Defreyne Justine , Schuylenbergh Judith Van , Wyverkens Elia , Motmans Joz , T'Sjoen Guy

Objectives: Transgender persons undergoing gender affirming hormonal and/or surgical care, are at risk of reduced fertility. Although theoretically, the options for assigned male at birth (AMAB) transgender people to fulfill their child wish are extensive, research in transgender women shows low fertility preservation utilization. Ideas and concerns of AMAB transgender persons regarding fertility preservation and child wish have never been reported in a large, non-clinical sam...

ea0056p972 | Male Reproduction | ECE2018

The relationship between PTEN mutations and resistance to androgen-deprivation therapy in prostate cancer

Alzoubi Abdallah , Alsmairat Aya , Al Bashir Samir , Alfaqih Mahmoud , Kheirallah Khalid

Background: Prostate cancer is the second leading cause of cancer-related deaths in men worldwide. A marker of poor survival in prostate cancer patients is the loss of the tumor suppressor gene PTEN (phosphoinositide-3-phosphatase). Deletion of PTEN occurs in approximately 40% of prostate cancer patients, and is associated with early biochemical recurrence, metastatic potential, and androgen-independence. Androgen-deprivation-therapy (ADT) remains the princip...

ea0056p973 | Male Reproduction | ECE2018

Male hypogonadism due to 46, XX Testicular disorder of sex development

Font Mercedes Noval , Soler Guillermo Serra , Portilla Ana Jimenez , Barcelo Carlos Antich , Povedano Santiago Tofe , Ribas Elena Mena , Macazaga Vicente Pereg

Introduction: 46,XX testicular disorder of sex development (DSD) is a rare syndrome, which is characterized by a female karyotype in discordance with a male phenotype. It is presented with primary hypogonadism, gynecomastia and infertility. About 80–90% of 46,XX testicular DSD cases are positive for SRY gene. Appearance of external genitalia and masculinization are usually normal in 46,XX SRY-positive casesClinical case: A 41-year-old male came with...

ea0056p974 | Male Reproduction | ECE2018

DicentricisochromosomeYp in adolescent with azoospermia

Loukil Fatma , Elleuch Mouna , Othmen Wafa Ben , Mnif Fatma , Ayed Ikhlas Ben , Belguith Neila , Mnif Mouna , Abid Mohamed

Background: Azoospermia is present at approximately 1% of the man. karyotype can show number and structure abnormalities of the sexe chromosomes.Case: 16 years old boy,who was refered to the departement of endocrinology for a failure to growth since 8 years old. This patient was resulting from a marriage between blood relations. He had a congenital bilateral hip luxation diagnosed since birth but untreated.He had a gait disorder with a low weight 32 kg &...

ea0056p975 | Male Reproduction | ECE2018

Prolactin concentration in male-to-female transsexual subjects following cross-sex hormone therapy

Hayon Maria , Blanquez David , del Carmen Serrano Maria , Aviles Maria Dolores , Torres Elena

Background: Male-to-female transsexual persons use estrogens + antiandrogens to adapt their physical bodies to the female sex.Estrogens are powerful stimulators of synthesis and release of prolactin and serum prolactin levels are usually somewhat increased following estrogen treatment.Objective: To determine prolactin levels and to assess the risk of development of prolactinoma in male-to-female transgender subjects following cross-sex hormone therapy (C...