Searchable abstracts of presentations at key conferences in endocrinology
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20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

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ECE 2018, 19 - 22 May 2018; Barcelona, Spain

Symposia

The role of sperm epigenome in fertility and inheritance

ea0056s5.1 | The role of sperm epigenome in fertility and inheritance | ECE2018

The quality control of the male germline transcriptome

Kotaja Noora

Accurate posttranscriptional regulation of gene expression is essential for the production of good quality spermatozoa. Active cell type-specific transcription, exceptionally diverse transcriptome, and finally, near-to-complete transcriptional silencing during the late steps of spermatogenesis create a high demand for effective RNA regulatory mechanisms. Furthermore, RNAs packed inside spermatozoa can mediate epigenetic inheritance of father’s acquired disorders, therefor...

ea0056s5.3 | The role of sperm epigenome in fertility and inheritance | ECE2018

Mechanisms of epigenetic inheritance through sperm: lessons we have learnt from model organisms

Vavouri Tanya

Our lifestyle habits and environmental exposures are typically considered to affect only our health (with the exception of pregnant mothers). Nevertheless, there is epidemiological evidence from human studies that adverse health consequences can also be observed in offspring and grand offspring (e.g. Roseboom et al., Molecular and Cellular Endocrinology, 2001). The mechanisms of trans- or inter-generational epigenetic inheritance are currently not known. We, and other...