Endocrine Abstracts

Obesity, a major public health problem, is associated with hypercholesterolemia and other metabolic disorders, which are potent risk factors for athero-thrombotic disease, a leading cause of mortality worldwide. Advances in both dietary and pharmacological interventions contribute significantly to prevention and treatment of modifiable risk factors. Consumption of purified soybean isoflavones was reported to reduce plasma and liver cholesterol levels. The precise mechanism has...

Background: Skin autofluorescence (SAF), measured with the AGE-reader, predicts cardiovascular disease (CVD) and type 2 diabetes (T2D). Thyroid hormone levels (TH) may affect this association. In the present study, we examined whether TH predict 4-years risk of T2D, CVD and mortality in the general population independently of SAF.Methods: We included 28245 participants (age 44±12 years, BMI 25.9±4.3 kg/m2) of the Dutch Lifelines Coho...

Introduction: Phenylketonuria (PKU) is a rare inherited metabolic disorder that leads to the toxic accumulation of phenylalanine (Phe) causing usually severe mental retardation and seizures. The basis of the lifelong therapy is low in natural-protein diet and Phe-free amino acid mixtures, that provide the daily necessary amino acids, vitamins and micronutrients, such as Iodine and Selenium. It is not well known, whether the adherence to the therapy can influence the thyroid fu...

Background: Sick euthyroid syndrome is a well-known condition and no additional treatment is often required. However various authors have postulated that there is an effect of abnormal thyroid function on the outcomes of hospitalized patients. In our study, we chose to study the effect of thyroid function abnormalities and their independent effect on mortality of critically ill patients who had no known prior thyroid diseases.Methods: Data was obtained f...

Introduction: Hypothyroidism is associated with increased risk of atherosclerosis. We assessed both carotid intima media thickness (CIMT), as a marker of atherosclerosis, and endothelial dysfunction in patients with hypothyroidism.Methods: We included 70 female patients with hypothyroidism (age 18–55 years), 40 patients with overt and 30 patients with subclinical hypothyroidism (SCH). Forty age and sex matched subjects with normal thyroid functions ...

Background: Optimal production of cellular energy and metabolites in mitochondria is one of the most important factors in endocrine organs that accomplish the momentary adaptation to ligand stimulation, such as insulin secretion and aldosterone biosynthesis. Although it has been suggested that thyroid gland function is also largely dependent on mitochondrial function, functional behavior of thyroid gland on compromised mitochondrial function remained to be identified. In this ...

Introduction and aim: Thyroid hormones (THs) regulates metabolism in adults, such as controlling energy balance by regulating energy expenditure and its storage. Hyperthyroidism increases thermogenesis, which results in the increase of the metabolic rate. THs, when combined with their receptor, can induce the expression of some genes, which can reflect on the content and activity of specific proteins. There are studies showing that THs affect the uptake of nutrients, such as g...

Thyroid hormones (TH) play a pivotal role in embryonal and postnatal development in vertebrates, hence, their secretion is highly regulated. In clinical practice TSH and free T4 (fT4) are commonly used as the most reliable parameters to evaluate the TH status. But they only represent the TH receptor β driven status of the hypothalamic-pituitary-thyroid axis while organ or tissue specific TH availability may be different. This discrepancy originates in the tissue specific ...

Introduction: Besides the classical thyroid hormones T4 and T3 the endogenous thyroid hormone metabolite 3,5-diiodothyronine (3,5-T2) attracted attention during the last years due to its metabolic activity. 3,5-T2 exerts thyromimetic action on the hypothalamus-pituitary-thyroid axis and the heart as well as on energy and lipid metabolism. In previous liver transcriptome analyses of 3,5-T2-treated lean and diet-induced obese male mice, effects on hepatic lipid, steroid, xenobio...