Endocrine Abstracts

Introduction: Antiphospholipid syndrome (APS) is an acquired thrombotic disorder. It mainly occurs with systemic disease or as a primary disorder. All organs may be involved by thrombosis. But endocrine disorders seen in antiphospholipid syndrome are rare. In the literature, rare cases of hypopituitarism with APS have been reported.

The observation: It is a 27 years old patient who consults for headache with diplopia. The interview underlines galactorrhea with amenorrhea lasting for 12 years. Physical examination revealed a visual field, a central facial paralysis and monoparesis right upper limb. In biology, it has a hyperprolactinemia to 40 times normal and central hypothyroidism. Anticardiolipin antibodies were positive. Synacthen test was normal. Pituitary MRI showed an expansive process parasellar right 3×2 cm, mainly cystic and hemorrhagic, with mass effect on the right cavernous sinus.

Conclusion: APS should be searched for whenever a history of adenoma with apoplexy is found associated with recurrent thrombosis.