Endocrine Abstracts

Tashkent Pediatric Medical Institute, department of endocrinology, Center of the Scientific and Clinical Study of Endocrinology, department f neuroendocrinoloy, Ministry of Health of the Republic of Uzbekistan.

Republic of Uzbekistan, 100125, Tashkent, Mirzo Ulugbek str. 56

M.Yu. Shakirova, Yu.M. Urmanova

The aim: To study dynamics of indicators of the questionnaire of QoL AGHD at assessment of quality of life at patients in 3 months and 6 months after operation of transnasal pituitary adenomectomy by the replacement treatment growth hormone Djintropin.

Material and methods: The patients (men-10 and women-3, aged from 18 up to 45 years) who were on stationary and out-patient inspection in the Center of Endocrinology, were selected in group of patients with the diagnosed GH deficiency (n=13) and received treatment by growth hormone Djintropin.

Results: Against the background of replacement therapy of GR “DjINTROPIN” reliable increase in values of the IGF-1, GR levels in blood (P<0.05) in 3 months of treatment and respectively increase in values of the IGF-1, GR levels in blood (P <0.05) and also blood GR (P < 0.05) in 6 months has been recorded. Significant reliable increase in level of calcium (P < 0.05), phosphorus (P <0.001) and also increase in activity of alkaline phosphatase is noted (P < 0.01) indicating acceleration of processes of bone metabolism against the background of the carried-out therapy. Decrease in levels of the general cholesterol and Lipids is recorded that demonstrates beneficial effect of GR “DJINTROPIN” on lipid exchange.

Conclusions: Assessment of change of anthropometrical indicators against the background of the carried-out therapy of GH “DJINTROPIN” has shown normalization of indicators of QoL according to the questionnaire of QoL AGHD: 10.2±2.5 points (during 6 months). Against the background of replacement therapy of GR “DJINTROPIN” reliable increase in initially low values of the IGF-1, GH levels in blood (P <0.05) in 3 months of treatment and also increase in STH (P <0.05) in 6 months has been recorded.