Introduction: The occurence of simultaneous medullary and papillary thyroid cancer is very rare. There were only 17 case reports in the literature, and fewer with Graves-Basedow disease associated. A retrospective study conducted at the National Institute of Endocrinology C. I. Parhon showed that 7,6%of the patients who underwent total thyroidectomy for Graves-Basedow disease had thyroid cancer. Recent studies show that specific cellular pathways are determined by the binding of anti-TSH receptor antibodies stimulating cellular growth and invasion and angiogenesis.
Case reports: We present two cases diagnosed with Graves-Basedow disease with total thyroidectomy and a histopathological report that showed the simultaneous presence of a papillary and medullary thyroid cancer.
Conclusions: Graves-Basedow disease can be associated with differentiated thyroid cancer and medullary cancer in the same patient.
19 May 2018 - 22 May 2018