ECE2018 ePoster Presentations Thyroid (37 abstracts)
Simultaneous medullary and papillary thyroid cancer in Graves-Basedow disease. Two case reports
Roxana Dumitriu , Eugenia Petrova , Andra Buruiana , Mircea Ghemigian & Adina Ghemigian
National Institute of Endocrinology ‘C. I. Parhon’, Bucharest, Romania.
Introduction: The occurence of simultaneous medullary and papillary thyroid cancer is very rare. There were only 17 case reports in the literature, and fewer with Graves-Basedow disease associated. A retrospective study conducted at the National Institute of Endocrinology ‘C. I. Parhon’ showed that 7,6%of the patients who underwent total thyroidectomy for Graves-Basedow disease had thyroid cancer. Recent studies show that specific cellular pathways are determined by the binding of anti-TSH receptor antibodies stimulating cellular growth and invasion and angiogenesis.
Case reports: We present two cases diagnosed with Graves-Basedow disease with total thyroidectomy and a histopathological report that showed the simultaneous presence of a papillary and medullary thyroid cancer.
Conclusions: Graves-Basedow disease can be associated with differentiated thyroid cancer and medullary cancer in the same patient.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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