Endocrine Abstracts

Introduction: The general function of vitamin D is to regulate phosphorus-calcium metabolism. Vitamin D takes part in other metabolic processes and it has an impact on body mass and on carbohydrate metabolism. Vitamin D also has an influence on nervous system’ functioning and on immune processes. Vitamin D deficiency increases risk of hyperplasia of the parathyroid glands, primary and secondary hyperparathyroidism and osteoporosis.

Objectives: To investigate the reference values of PTH, considering response normalization of vitamin D levels in different age groups.

Methods: The study included 423 patients of both sexes between the age of 18 and 90. The patients were included between September 2017 and November 2017. All patients with endocrine pathology were observed in Moscow outpatient clinics no 5 and no 210. All patients were examined for level 25 (OH) D, PTH, total calcium and creatinine in the blood.

Results: 390 patients in the selected age groups had a vitamin D deficiency, which was lower than the reference values. Some of the patients had increased level of PTH. Decreased level of PTH was revealed in all age groups, due to the process of taking saturating doses of the 25(OH)D. Herewith, increased level of PTH was revealed in the age group 60–74 and 75–90.

Conclusion: The results have shown that majority of patients have a pronounced vitamin D deficiency associated with insufficient insolation and malnutrition. PTH level reduction was noticed, due to the process of taking native vitamin D. Respectively, it can be assumed that the reference values for PTH are overestimated in the territory of the Russian Federation, because previous measurements were done without regard to saturation with 25(OH)D.