Endocrine Abstracts

Introduction: Gestational diabetes mellitus (GDM) is associated with an increase of maternal-fetal complications. Continuous glucose monitoring system (CGMS) detects postprandial hyperglycemia and hypoglycemia during 24h.

Methods: Women with GDM in gestational weeks 26–32 were allocated a CGMS (Ipro^TM2) after diagnosis in an observational prospective study. It was analysed: Mean glucose and standard deviation, area under the curve (AUC) with glucose >140 and <70. Percentage of glucose above or below the limit of normality before and after breakfast, lunch, dinner and night. (Target ranges: before meals 70–95, after meal 70–140 and night 70–120 (expressed: mg/dl)).

Results: n=65. Maternal age 33±4.46 years (>35 years =36.9%), family history of diabetes 65.3%, personal history of diabetes 21.3%, prepregnancy BMI 26.21±4.74 kg/m² (>30 kg/m² =23.1%), weigh gain 8.15±5.47 kg, HbA1c 4.9%, insulin treatment 27.7%.

CGMS: Glucose before breakfast 87.63±7.98, after breakfast 116.89±19.57, before lunch 86.20±10.08, after lunch 111.08±18.19, before dinner 92.32±11.79 and after dinner 109.22±16.27 (mg/dl)

AUC >140=0.62 and <70=0.64.

Time glucose above or below range:

Conclusions: SMCG showed preprandial hyperglycemia, mainly before dinner. Few hypoglycemias were detected predominantly before lunch and night. Patients with GDM should have a narrow monitoring before and after every meal, especially before dinner, to prevent maternal-fetal complications.