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Endocrine Abstracts (2018) 56 P1162 | DOI: 10.1530/endoabs.56.P1162

Hopital Central De L’armée, Alger, Algeria.


Introduction: Familial follicular cell-derived tumors may account 5–15% of thyroid carcinoma cases. Defined as the attainment of two or more first-degree relatives by thyroid cancer in the absence of a known familial syndrome. When three or more family members are affected, the probability that the disease has a familial origin is 99.9%. We report the case of a family of 4 siblings affected.

Observation: – Patient aged 43 years, without a personal or family history particular, had a total thyroidectomy for a left lobe nodule classified Tirads IVb of 25 mm, anatomo-pathological study: papillary micro carcinoma of 4 mm vesicular variant and constituted of 80% of oncocytic cells.

– His sister 46 years had a total thyroidectomy for a suspected nodule Tirads V, anatomo-pathological study: 4 cm nodule with a well-differentiated vesicular carcinoma with vascular invasion of the capsule.

– Another sister 40 years operated as a part of screening with anatomo-pathological study: papillary carcinoma in its vesicular variant, encapsulated and bifocal.

– A brother 33 years, had a total thyroidectomy for a Tirads VIb nodule, anatomo-pathological study: papillary carcinoma in its solid variant.

Discussion: It is now widely recognized that familial cancers are more aggressive than sporadic ones. Characterized by, tumor multifocality, local invasion with lymph node metastasis, and local or regional recurrence. At present, the specific genetic basis is not clear. Studies suggest that familial cancers has an autosomal dominant behavior with incomplete penetrance and variable expression. Early diagnosis and treatment are very important to improve the quality of life and survival of patients.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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