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Endocrine Abstracts (2018) 56 P192 | DOI: 10.1530/endoabs.56.P192

ECE2018 Poster Presentations: Calcium and Bone Bone ' Osteoporosis (38 abstracts)

Osteoprotegerin and bone metabolism markers in postmenopausal women with primary hyperparathyroidism

E.V. Brutskaya-Stempkovskaya 1 , A.P. Shepelkevich 1 , N.V. Karlovich 1, , A.V. Yurenia 2 , A.S. Kazlova 2 , A.V. Sosedkova 2 & Y.A. Hostina 3


1Belarusian State Medical University, Minsk, Belarus; 2Minsk City Dispensary of Endocrinology, Minsk, Belarus; 3Minsk Consulting and Diagnostic Centre, Minsk, Belarus.


Objective: To study relationship between osteoprotegerin (OPG) and bone metabolism markers in postmenopausal women with primary hyperparathyroidism (PHPT) compared postmenopausal women without PHPT.

Materials and methods: We studied 30 postmenopausal women with PHPT, average age 62.5±6.12. The control group were 16 postmenopausal women without PHPT, mean age 59.7±6.28 in physiological menopause. We analyzed anthropometric data and history of fractures. Examination: total calcium, Ca++, phosphorus, albumin, creatinine, alkaline phosphatase, PTG, OPG, crosslaps, osteocalcin.

Results: The were no differences in the age (U=138.5, P=0.052), height, m (U=216.5, P=0.99), weight, kg (U=202.5, P=0.72), BMI kg/m2 (U=196.5, P=0.61), duration of menopause, years (U=146.5, P=0.08). Calcium total was 2.75 (2.69- 2.82) mmol/l in postmenopausal women with PHPT vs 2.44 (2.31-2.50) mmol/l in the control group, U=4, P=0.001; Ca++1.27 (1.26-1.36) mmol/l vs 1.04 (0.98-1.14) mmol/l in the control group, U=4.24, P<0.0001; phosphorus 0.94 (0.80-1.06) mmol/l vs 1.36 (1.32-1.40) mmol/l in the control group, U=0.001, P=0.029; alkaline phosphatase 122.0 (89.0-146.0) mmol/l vs 84.0 (72.0-84.0) mmol/l in the control group, U=4.0, P=0.126; PTG 111,1 (88.5-144.3) pg/ml vs 54.7 (35.4-55.3) pg/ml, U=0.001, P<0.0001; osteocalcin 32.33 (21.95-40.33) ng/ml vs 19.9 (16.0-27.8) ng/ml, U=23, P=0.07; crosslaps 0.60 (0.37-0.79) vs 0.46 (0.33-0.54), U=16, P=0.2. Significant differences were detected in calcium total, Ca++, phosphorus, PTG in postmenopausal women with PHPT compared control group, there were no differences in alkaline phosphatase, osteocalcin, crosslaps. We detected negative correlation between OPG level and calcium total rs=−0.6, P <0.05, rs=−0.7, P<0.05, PTG rs=−0.6, P<0.05.

Conclusion: The results of the study confirmed high bone metabolism in postmenopausal women with PHPT compared control group. The results may indicate association between PTG, calcium level and OPG.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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