ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Cardiovascular Endocrinology and Lipid Metabolism (25 abstracts)
B-type natriuretic peptide: a biomarker of cardiovascular risk in type 2 diabetes.
Ibtissem Oueslati 1 , Nadia Khessairi 1 , Emna Talbi 2 , Meriem Yazidi 1 , Fatma Chaker 1 , Jaouida Abdelmoula 2 , Melika Chihaoui 1 & Hedia Slimane 1
1Department of Endocrinology, La Rabta Hospital, Tunis, Tunisia; 2Laboratory of Biochemistry, Charles Nicolle Hospital, Tunis, Tunisia.
Background: Cardiovascular stratification and prevention in type 2 diabetic patients represent a major public health preoccupation in order to reduce their mortality. Several methods of detecting atherosclerosis have been developed such as biomarkers. The aim of this study was to evaluate the association between B-type natriuretic peptide (BNP) and cardiovascular risk (CVR) in type 2 diabetic patients.
Methods: We conducted a cross-sectional study in 71 type 2 diabetic patients (38 patients with at least one cardiovascular disease (CVD) and 33 patients without any CVD). Their CVR level was estimated using Framingham score (FS). All patients had BNP and high-sensitivity C-reactive protein (hs-CRP) measurements. BNP threshold was 10 pg/ml.
Results: The average level of BNP was 27.65±31.95 pg/ml. It was significantly correlated with body weight (r=0.3, P=0.01), waist circumference (r=0.2, P=0.03), low HDL cholesterol (r=−0.26; P=0.02) and the number of CVR factors (r=0.38, P=0.001). It was significantly higher in patients with hypertension (P<0.001), dyslipidemia (P=0.02), metabolic syndrome (P=0.009), high CVR level (P=0.04), coronary heart disease (CHD) (P=0.004) and microangiopathy (P=0.03). High level of BNP was associated with an age ≥ 45 years for men and ≥ 55 years for women (hazard ratio [HR] 9.36, P=0.03), hypertension (HR=7.27, P<0.001), metabolic syndrome ((HR=3.64; P=0.03), high CVR level (HR=6.6, P=0.01), CHD (HR=2.8, P=0.04), diabetic retinopathy (HR=3.14, P=0.03) and diabetic nephropathy (HR=3.12, P=0.03). BNP had higher sensibilities (se) and specificities (sp) than Hs-CRP as a marker of high CVR level (se: 62.3% vs 41.7%; sp: 80% vs 52.6%, respectively).
Conclusion: Our results demonstrated significant associations between BNP, high CVR level, CHD and microangiopathy in type 2 diabetic patients. However, prospective controlled studies including a large population are needed to confirm these results.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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