Endocrine Abstracts

Purpose: Transcription factor 7-like 2 (TCF7L2) variants are known risk factors of type 2 diabetes (T2DM).However; this association is not consistent among different populations. The current study aimed at investigating the relationship between rs 7903146, rs 12255372 variants of TCF7L2 and susceptibility to T2DM.

Patients and methods: This case control study included 60 diabetic patients and 60 matched unrelated healthy controls. Genotyping was performed by using Real Time-PCR. The frequency of genotypes and alleles, anthropometric measures, glycemic indices, HOMA-IR and lipid profile were evaluated in patients and control.

Results: Regarding rs 7903146, TT genotype was more frequent in healthy controls (43.3%) than diabetic patients (20%) (OR=0.291, 95% CI=0.108–0.788, P=0.015). T allele was more frequent in healthy control (61.7%) than diabetic patients (44.2%) and it was associated with lower risk of diabetes (OR=0.492, 95% CI=0.294–0.823, P=0.007). In contrast, T allele of rs12255372 had no significant relation to diabetes risk (OR=0.602, 95% CI=0.361–1.005, P=0.052). There was no statistically significant difference of frequency of any rs12255372 genotypes between cases and controls.

Conclusion: The study confirmed the association of TCF7L2 (rs 7903146) and T2DM, while failed to detect any association between TCF7L2 (rs 12255372) and susceptibility to T2DM.