Endocrine Abstracts

Objective: To compare screening strategies for type 2 diabetes mellitus (DM) and impaired glucose tolerance (pre-DM) in woman with polycystic ovary syndrome (PCOS).

Design: Prospective study.

Patient(s): Adult women with PCOS (n=62) according to NIH criteria.

Main outcome measure (s): Subjects were screened for pre-DM and DM using a 2-hour glucose tolerance test (GTT), hemoglobin A1c (HbA1c), or fasting plasma glucose (FPG) according to ADA guidelines. Screening approaches were compared using Cohen’s Kappa (κ) coefficient.

Result(s): DM and pre-DM were diagnosed by GTT in 3 (4.8%) and 11(17.7%) of subjects, respectively. Screening with FPG and HbA1C failed to identify 100% of DM subjects. GTT and HA1c had only slight agreement (κ=0.075)

Conclusion (s): Women with PCOS should be screened for Pre-DM and DM using GTT. Fasting plasma glucose levels and HA 1c were suboptimal predictors of DM in our cohort.