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Endocrine Abstracts (2018) 56 P926 | DOI: 10.1530/endoabs.56.P926

Medical faculty of the P.J. Šafárik University, Košice, Slovakia.


Objectives: Insulin-like growth factors 1 and 2 (IGF1 and IGF2) are widely expressed mitogenic peptides playing a role in the fetal developement and differentiation. Evidence suggest their possible involvement in the pathogenesis of metabolic syndrome and probably in polycystic ovary syndrome (PCOS).

Aim: Aim of the study was to assess the relationship of serum IGF1, IGF2 and IGF binding protein 3 (IGFBP3) levels to steroid hormones and metabolic parameters in PCOS women.

Subjects and methods: The study included 56 Caucasian women diagnosed with PCOS (age 28.62±5,2 years, range 19-43). All patients were examined for parameters of glucose and lipid metabolism, sexual steroid hormones and serum IGF1, IGF2 as well as IGFBP3 levels.

Results: Nonobese PCOS women had higher IGF1 than those with BMI>25 with borderline significance (211±15.6 v.s. 160.7±16, P=0.06). No significant differences in serum IGF2 and IGFBP3 levels in women according to BMI have been detected. IGF1 negatively correlated with HOMA IR (R2=0.23, P=0.03), waist circumference (R2=0.15, P=0.045) and triacylglycerols (R2=0.23, P=0.02), but not with sexual steroids. On the other side IGFBP3 was in positive correlation with TAG (R2=0.22, P=0.0215), total cholesterol (R2=0.2, P=0,028), LDL cholesterol (R2=0.2, P=0.03), dihydrotestosterone (R2=0.14, P=0.049) and estrone (R2=0.21, P=0.014). Neither correlation between serum IGF2 and metabolic variables nor between IGF2 and steroid hormones have been detected.

Conclusion: We conclude that higher IGFBP3 level is more related to metabolic parameters and steroid hormones in PCOS women than both serum IGF1 and IGF2. Further studies are needed.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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