Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2018

Glasgow, UK
19 Nov 2018 - 21 Nov 2018

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The Society for Endocrinology BES will take place 19-21 Nov 2018 in Glasgow. Come and exchange knowledge, share experiences and strengthen collaborations across our global community of endocrinologists.

Oral Communications

The best of the best

ea0059oc2.1 | The best of the best | SFEBES2018

24-hour adrenal steroid rhythms are readily detected by ULTRADIAN automated ambulatory microdialysis in man

Upton Thomas , Methlie Paal , Russell Georgina , Tsagarakis Stelios , Kampe Olle , Lightman Stafford , Husebye Eystein

Background: Hormones oscillate in circadian and ultradian rhythms. Single time point samples are difficult to interpret and high frequency measurements are time consuming, expensive and invasive. We developed a minimally invasive technique of ambulatory, automated microdialysis. This allows frequent 24-hour sampling of interstitial fluid while participants continue normal daily activities.Methods: Healthy volunteers (age 18–68, no regular medication...

ea0059oc2.2 | The best of the best | SFEBES2018

Comparison of acute effects of corticosterone versus cortisol (hydrocortisone) infusion in adults with congenital adrenal hyperplasia

Kyle Catriona , Boyle Luke , Nixon Mark , Homer Natalie , Andrew Ruth , Freel Marie , Stimson Roland , Walker Brian

Congenital adrenal hyperplasia (CAH) is associated with poor health outcomes. This is, in part, because doses of glucocorticoid sufficient to suppress excess adrenal androgens are also associated with adverse metabolic effects such as insulin resistance. This toxicity occurs with efficacious doses of all commonly prescribed glucocorticoids (hydrocortisone, prednisolone and dexamethasone). However, the glucocorticoid corticosterone may have an improved therapeutic index because...

ea0059oc2.3 | The best of the best | SFEBES2018

Prospective serum thyroid function and cognitive decline in the very old: the Newcastle 85+ study

Gan Earn , Yadegarfar Mohammad , Jagger Carol , Pearce Simon

Context: Perturbations in thyroid function are common in older people, and subclinical hyperthyroidism has been associated with increased risk of dementia in people aged 55 years and above. The significance of subtle perturbations of thyroid function in the very old remains poorly understood.Objective: This study sought to determine if subtle abnormalities of thyrotropin and variations of free thyroid hormones within the reference range correlate with co...

ea0059oc2.4 | The best of the best | SFEBES2018

Biochemical analysis of radioiodine uptake enhancement in endocrine cancer

Alshahrani Mohammed , Fletcher Alice , Thornton Caitlin , Brookes Kate , Nieto Hannah , Thompson Rebecca , Read Martin , Boelaert Kristien , McCabe Christopher , Smith Vicki

The most common form of endocrine cancer is differentiated thyroid cancer (DTC). Outcomes of DTC largely depend on radioiodine treatment, which is mediated the sodium-iodide symporter (NIS). However, many tumours exhibit NIS dysregulation, resulting in a poorer prognosis. Since breast cancer can also overexpress NIS, albeit of limited function, radioiodine treatment may be a promising treatment option. Our previous data show that overexpression of the pituitary tumor-transform...

ea0059oc2.5 | The best of the best | SFEBES2018

Using integrative lipid systems biology to understand the role of Liver X receptors (LXRs) in male reproduction

Jarvis Sheba , Gethings Lee , Gadeleta Raffaella , Claude Emmanuelle , Winston Robert , Williamson Catherine , Bevan Charlotte

Introduction: LXRs are transcription factors that regulate cholesterol homeostasis and likely modulate other aspects of lipid metabolism. In the testis, tightly regulated lipid metabolism is crucial to maintain fertility. Testicular LXRs are highly expressed but their role in regulating lipid homeostasis is not fully understood. Lxrα/β double knockout male mice (Lxrα/β DKO) are sterile by 7 months of age, with aberrations in lipid...

ea0059oc2.6 | The best of the best | SFEBES2018

Overexpression of SKAP2 in familial AIP mutation negative somatotrophinomas

Al Jabir Hussain , Barry Sayka , Korbonits Marta

Background: Germline mutations in the aryl-hydrocarbon receptor interacting protein (AIP) gene have been implicated in the tumorigenesis of patients with familial isolated pituitary adenoma (FIPA). Around 25% of FIPA patients have an identified AIP mutation; in the remainder of FIPA patients, molecular mechanisms involved in pituitary tumorigenesis have yet to be elucidated.Aims: To identify the genes and molecular mechanisms involved i...