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Endocrine Abstracts (2018) 59 P107 | DOI: 10.1530/endoabs.59.P107

SFEBES2018 Poster Presentations Diabetes & cardiovascular (27 abstracts)

Anacardium occidentale upregulates GLP-I and Insulin Gene Expression in Normoglycemic Rats

Victor Ukwenya 1 , Olaposi Omotuyi 2 & Ojochenemi Enejo 3


1School of Health and Health Technology, Federal University of Technology, Akure, Akure, Nigeria; 2Center for Bio-Computing and Drug Development, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Akungba, Nigeria; 3Phytomedicine Research Group, Center for Genomics Research andfInnovation, National Biotechnology Development Agency, Abuja, Nigeria, Abuja, Nigeria.


Anacardium occidentale is a multi-purpose tree of the anacardae family with great economic and medicinal value. The leaf of the tree has been reported to possess hypoglycaemic and anti-diabetic properties. However, literature is devoid of any molecular basis for the potent effects observed. This study evaluated the molecular mechanisms underlying the efficacy and safety of the leaves by investigating glucagon-like peptide 1, insulin and kidney injury molecule genes using beta actin as the control for gene expression. Normoglycaemic Wistar rats were separated experimental and control groups. Experimental rats were fed 30% feed formulation of A. occidentale leaf powder while control rats were fed ordinary rat chow. Feeding occurred ad libitum over a period of three days after which the rats were fasted overnight and sacrificed the following day. The pancreas, kidney and intestinal crypts were excised for molecular studies. A. occidentale fed rats showed 18.9% increase in insulin and 50% in GLP-1 compared to control rats. There was no significant difference in Kim-1 expression compared to control (P<0.05). These results shed light on the molecular basis of the well reported anti-diabetic potency of A. occidentale and its low toxicity to the kidney.

Volume 59

Society for Endocrinology BES 2018

Glasgow, UK
19 Nov 2018 - 21 Nov 2018

Society for Endocrinology 

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