Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2018) 59 P183 | DOI: 10.1530/endoabs.59.P183

SFEBES2018 Poster Presentations Reproduction (23 abstracts)

Impact of ethnicity on the change in total testosterone, haematocrit and prostate-specific antigen with Testosterone undecanoate treatment

Punith Kempegowda 1, , Lauren Quinn 3 , Anupama Rayachaudhari 1 , Lisa Shepherd 1 , Samina Kauser 1 , Joht Singh Chandan 4 , Tom Thomas 4 , Asad Rahim 1 & Andrew Bates 1

1University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; 2Institute of Metabolism and Systems Research, Birmingham, UK; 3University of Birmingham Medical School, Birmingham, UK; 4Health Education West Midlands, Birmingham, UK.

Background: Current guidelines recommend regular monitoring of total testosterone, haematocrit and prostate-specific antigen (PSA) when androgen-deficient males are commenced on testosterone replacement therapy (TRT). The aim is to restore serum total testosterone to the mid-normal range, whilst maintaining haematocrit and PSA at the recommended levels. Limited studies have assessed the impact of ethnicity on these biochemical parameters.

Aim: To measure the impact of ethnicity on total testosterone, haematocrit and PSA following Testosterone undecanoate replacement.

Method: A retrospective analysis of 50 male patients, treated with testosterone undecanoate between 2006 to 2017, in a large secondary care centre was performed. Changes in total testosterone, haematocrit and PSA over 10 years of treatment were analysed. Mann-Whitney U test was used to assess differences in these parameters of the two ethnic groups- Caucasians and Asians.

Results: Thirty-one Caucasians (age: median (IQR) 54.0 years (42.5–68.0); duration of treatment 1253.0 days (537.5–2066.8) and 19 Asians (age: median (IQR) 52.0 years (42.0–68.0); duration of treatment 1264.0 days (540.0–2077.0) were treated with TRT during the study period. There was no significant difference in total testosterone levels between the two ethnicities. There was a significant rise in haematocrit in Asians compared to Caucasians in the first (P=<.000) and sixth year (P=.029) of therapy. PSA was significantly higher in Caucasians compared to Asians in the second (P=.022), fourth (P=.014), fifth (P=.016), seventh (P=.032), eighth (P=.012) and ninth (P=.016) year of therapy.

Conclusion: Differences in haematocrit and PSA between the two ethnic groups varied from year to year. Caucasians have a tendency towards higher PSA rise compared to Asians with TRT. Particular focus on haematocrit may be needed in the first year of TRT in Asians.

Volume 59

Society for Endocrinology BES 2018

Glasgow, UK
19 Nov 2018 - 21 Nov 2018

Society for Endocrinology 

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