Searchable abstracts of presentations at key conferences in endocrinology
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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Guided Posters

Adrenal and Neuroendocrine - Tumour

ea0063gp1 | Adrenal and Neuroendocrine - Tumour | ECE2019

68Ga-exendin-4 PET/CT detects insulinomas in patients with hypoglycemia in multiple endocrine neoplasia type 1

Antwi Kwadwo , Nicolas Guillaume , Fanis Melpomeni , Heye Tobias , Pattou Francois , Grossman Ashley , Chanson Philippe , Reubi Jean Claude , Perren Aurel , Gloor Beat , Vogt Deborah , Wild Damian , Christ Emanuel

Context: Surgical intervention is advised in patients with multiple endocrine neoplasia type-1 (MEN-1) with non-functioning pancreatic neuroendocrine tumors (PanNET) and a size ≥20 mm. However, functioning PanNET such as patients with endogenous hyperinsulinemic hypoglycemia (EHH) due to (one or multiple) insulinomas should be treated surgically independent of size. Reliable preoperative localization of insulinomas is critical for surgical strategy.<p class="abstext"...

ea0063gp2 | Adrenal and Neuroendocrine - Tumour | ECE2019

Lanreotide therapy vs wait-and-see in patients with pancreatic neuroendocrine tumors

Faggiano Antongiulio , Modica Roberta , Calzo Fabio Lo , Camera Luigi , Napolitano Vincenzo , Altieri Barbara , De Cicco Federica , Bottiglieri Filomena , Sesti Franz , Isidori Andrea M. , Colao Annamaria

Background & Aim: Pancreatic neuroendocrine tumors (pNETs) are detected in >80% of MEN1 patients. MEN1 pNETs are well differentiated G1-G2 NETs. They are usually not surged unless a size >1–2 cm or a growth rate >0.5 cm per year. Somatostatin analogues represent one of the main therapeutic option in patients affected with G1-G2 NETs. However, neither somatostatin analogues nor other therapies have been prospectively evaluated in clinical trials specificall...

ea0063gp3 | Adrenal and Neuroendocrine - Tumour | ECE2019

ProGRP is an effective marker for disease monitoring in lung carcinoids with non-informative chromogranin A: Lessons from clinical practice

Oleinikov Kira , Grozinsky-Glasberg Simona , Gross David J , Nechushtan Hovav , Peretz Tamar , Maimon Ophra , Nisman Beni

Introduction: The histologic classification of lung carcinoids (LCs) as typical (TCs) and atypical (ACs) highlights its role as major prognostic factor for these patients. However, in the absence of sensitive biomarkers to effectively predict tumor behavior, long-term imaging surveillance is recommended for disease monitoring. Limited data suggest that progastrin-releasing peptide (ProGRP) may have diagnostic & monitoring utility in LCs.Aim(s): To ev...

ea0063gp4 | Adrenal and Neuroendocrine - Tumour | ECE2019

Two cases of pseudopheochromocytoma due to Obstructive sleep apnea: which mechanisms?

Marmouch Hela , Jenzri Haythem , Mrabet Houssem , Fekih Hamza , Khochtali Ines

Introduction: The obstructive sleep apnea syndrome (OSAS) has a well-documented association with increase cardiovascular morbidity and mortality. The patients with OSAS have a high prevalence of hypertension and the OSAS may present similar to a pseudo-pheochromocytoma (PPH). We report two cases with PPH caused by OSAS; a common medical condition which is less recognized as a cause of raised catecholamines.Observations: Case 1: 54 year-old man had a hist...

ea0063gp5 | Adrenal and Neuroendocrine - Tumour | ECE2019

Pheochromocytoma’s of MENX rats belong to the pseudo-hypoxia cluster

Mohr Hermine , Gulde Sebastian , de Martino Daniela , Richter Susan , Pellegata Natalia

Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors derived from chromaffin cells of the adrenal medulla and paraganglia of the autonomic nervous system, respectively. Despite a common origin, these tumors are quite heterogeneous in terms of driver mutations, copy number alterations and activated downstream-signaling pathways. Genome wide expression analysis has identified at least three main tumor clusters: a pseudo-hypoxic cluster, one with activation ...

ea0063gp6 | Adrenal and Neuroendocrine - Tumour | ECE2019

Cellular modelling of SDH-associated pathomechanism of pheochromocytomas and paragangliomas

Sarkadi Balazs , Meszaros Katalin , Krencz Ildiko , Zakarias Sara , Nemeth Kinga , Barja Gabor , Sebestyen Anna , Papay Judit , Borka Katalin , Hujber Zoltan , Toth Miklos , Igaz Peter , Chinopoulos Christos , Patocs Attila

Introduction: The capability of cancer to accommodate to special metabolic circumstances is a hallmark of it’s existence. Pheochromocytoma/paragangliomas (Pheo/PGL) are rare neuroendocrine tumors with strong and specific metabolic phenotype due to mutations of genes encoding succinate dehydrogenase (SDH) subunits. In this study our aim was to evaluate the expression of glutaminase-1 in hereditary Pheo/PGL tissues and to inhibit SDH activity via pharmacological treatments ...

ea0063gp7 | Adrenal and Neuroendocrine - Tumour | ECE2019

Parafibromin is regulated by ubiquitin specific protease 37 (USP37) and the c-terminus of USP37 interacts with the beta-catenin binding region of CDC73 in hyperparathyroidism-jaw tumor syndrome

Kim Su Yeon , Lee Ji-young , Jo Kwan Hoon , Mo Eun Yeong , Kim Eun Sook , Han Je Ho , Baek Kwang-Hyun

CDC73 (also known as HRPT2) encodes parafibromin and is known to be the causative gene of hyperparathyroidism-jaw tumor (HPT-JT) syndrome. There is no known ubiquitination of parafibromin, and the deubiquitinating enzyme (DUB) for parafibromin has not been identified to date. Full-length DUB cDNAs encoding 58 family members of ubiquitin specific proteases (USPs) were subcloned. The DUB cDNA was used to identify parafibromin interacting by yeast two-hybrid screening. W...

ea0063gp8 | Adrenal and Neuroendocrine - Tumour | ECE2019

Pheochromocytoma: Positive predictive values of mildly-elevated urinary fractionated metanephrines in a large cohort of community-dwelling patients

Hirsch Dania , Grossman Alon , Nadler Varda , Alboim Sandra , Tsvetov Gloria

Introduction: The importance of highly sensitive screening tests for pheochromocytoma/paragnaglioma (PPGL) is clear. However, a low level of specificity may lead to unnecessary biochemical and imaging investigations and even to needless surgical procedures. Therefore, in patients with elevated values of metanephrines, it is essential to establish a rational threshold for performing prompt thorough diagnostic investigations rather than opting for active surveillance.<p clas...

ea0063gp9 | Adrenal and Neuroendocrine - Tumour | ECE2019

IGF-1 splice variants’ expression in adrenal gland neoplasms- Possible role in adrenal tumorigenesis

Kyriakopoulos Georgios , Nasiri-Ansari Narjes , Angelousi Anna , Philippou Anastasios , Karapanagioti Angeliki , Zografos Georgios , Aggeli Chrysanthi , Choreftaki Theodosia , Tiniakos Dina , Rontogianni Dimitra , Dimitriadis Georgios , Kaltsas Gregory , Papavassiliou Athanasios G. , Kassi Eva

Introduction: IGF-1 overexpression has been associated with tumorigenesis. IGF-1Ea, IGF-1Eb and IGF-1Ec isoforms were shown to be regulated differently in cancer. IGF-1Ec and IGF-1Eb overexpression has been positively associated with cell survival and proliferation in various tumors. Elevated IGF1Eb/IGF-1Ea ratio has been suggested as a biomarker of cervical cancer prognosis. Herein, we aimed to examine the expression of IGF-1 isoforms in human adrenocortical carcinomas (ACCs)...

ea0063gp10 | Adrenal and Neuroendocrine - Tumour | ECE2019

Brown fat proliferation- A rare complication of Phaeochromocytoma

Sim Sing Yang , Haider Najaf , Meeking Darryl , Flowers David

Phaeochromocytoma is a catecholamine producing tumour arising from the adrenomedullary chromaffin cells. It produces hormones such as epinephrine, norepinephrine, catecholamine and dopamine. (1) There have been some case reports describing an association between Brown adipose tissue (BAT) accumulation due to catecholamine excess caused by a phaeochromocytoma. We present a similar case in this abstract. A 77 year old lady was referred to the community geriatricians with symptom...

ea0063gp11 | Adrenal and Neuroendocrine - Tumour | ECE2019

Corticotropinoma as the underlying cause of intermittent Cushing’s syndrome in a patient previously diagnosed with primary pigmented adrenocortical disease (PPNAD) – a case report

Łebek-Szatańska Agnieszka , Stelmachowska-Banaś Maria , Zieliński Grzegorz , Zgliczyński Wojciech , Nowak Karolina M. , Styk Andrzej , Maksymowicz Maria , Roszkowska-Purska Katarzyna , Papierska Lucyna

Background: The diagnostic process to unveil the underlying cause of endogenous Cushing’s syndrome (CS) is often challenging. Sometimes, atypical manifestation of the disease or only periodic hypercortisolaemia with spontaneous resolutions are observed and make the diagnosis even more difficult. Although it is common in primary pigmented nodular adrenocortical disease (PPNAD), pituitary corticotroph adenoma can manifest itself as cyclic Cushing’s syndrome as well.</p...

ea0063gp12 | Adrenal and Neuroendocrine - Tumour | ECE2019

Functional mixed oncocytic adrenocortical neoplasm presenting as an asymptomatic adrenal mass

Racolta Niculina , Homsi Sarah , Keller Philippe , Lerintiu Felix , Linder V , Goichot Bernard , Smagala Agnes

Oncocytic adrenocortical neoplasm (OAN) represents a rare variant of adrenocortical carcinoma (ACC) with less than 150 cases reported in the literature. OANs account for 1.8% of adrenal masses, predominantly in adults and usually presenting as large tumors featuring hormonal secretion in 20% of cases. Accurate histological characterization of OANs is crucial as this subtype is believed to be more indolent in clinical behavior. There are 3 categories of OANs: pure oncocytic, mi...

ea0063gp13 | Adrenal and Neuroendocrine - Tumour | ECE2019

KCTD20, a new gene in cortisol-secreting adrenocortical tumors related to inactivating mutations of the Carney Complex gene (PRKAR1A)

Briere Mathilde , Ragazzon Bruno , Yu Bo , Bouchekioua Abdelghani , Bertherat Jerome , Rizk-Rabin Marthe

Introduction: Adrenal Cushing due to bilateral multiple adrenal tumors known as Primary Pigmented Nodular Adrenocortical Disease (PPNAD) can be observed in the multiple neoplasia syndrome Carney Complex or as an isolated disease. In both situations germline inactivating mutations of PRKAR1A (regulatory subunit R1A of PKA) can be observed. The loss of PKA R1A results in an increased PKA activity. Comparison of the transcriptome of PPNAD and stably transfected H295R adr...

ea0063gp14 | Adrenal and Neuroendocrine - Tumour | ECE2019

Endoscopic ultrasound guided radiofrequency ablation (EUS-RFA) as a novel therapeutic approach in highly-selected pancreatic functioning and non-functioning neuroendocrine neoplasms (pNENs) patients: Preliminary report

Oleinikov Kira , Dancour Allain , Epshtein Julia , Benson Ariel , Mazeh Haggi , Tal Ilanit , Livovsky Dan , Goldin Eran , Gross David J , Jacob Harold , Grozinsky-Glasberg Simona

Introduction: EUS-RFA is rapidly emerging as a possible treatment alternative for patients with pNENs who are poor surgical candidates.Aim(s): To summarize our experience in terms of feasibility, safety and efficacy of EUS-RFA in a cohort of patients with functional and non-functional pNENs.Materials and methods: Retrospective case series of pNENs patients treated with EUS-RFA at two tertiary referral centers in Israel between Marc...